7sh0 - Revision history

OCA at 09:35, 25 October 2023

2023-10-25T09:35:01Z

←Older revision		Revision as of 09:35, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7sh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SH0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7sh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SH0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GIY:(2S)-N-hydroxy-3-(4-methoxyphenyl)-2-[4-({[5-(pyridin-2-yl)thiophene-2-sulfonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanamide'>GIY</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GIY:(2S)-N-hydroxy-3-(4-methoxyphenyl)-2-[4-({[5-(pyridin-2-yl)thiophene-2-sulfonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanamide'>GIY</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sh0 OCA], [https://pdbe.org/7sh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7sh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sh0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sh0 OCA], [https://pdbe.org/7sh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7sh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sh0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:06, 1 February 2023

2023-02-01T12:06:28Z

←Older revision		Revision as of 12:06, 1 February 2023
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	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN]] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref>	+	[https://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref>

	==See Also==		==See Also==

OCA at 04:58, 8 September 2022

2022-09-08T04:58:55Z

←Older revision		Revision as of 04:58, 8 September 2022
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	==CRYSTAL STRUCTURE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (ERAP2) COMPLEX WITH A HIGHLY SELECTIVE AND POTENT SMALL MOLECULE==		==CRYSTAL STRUCTURE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (ERAP2) COMPLEX WITH A HIGHLY SELECTIVE AND POTENT SMALL MOLECULE==
-	<StructureSection load='7sh0' size='340' side='right'caption='[[7sh0]]' scene=''>	+	<StructureSection load='7sh0' size='340' side='right'caption='[[7sh0]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SH0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7sh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SH0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sh0 OCA], [https://pdbe.org/7sh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7sh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sh0 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GIY:(2S)-N-hydroxy-3-(4-methoxyphenyl)-2-[4-({[5-(pyridin-2-yl)thiophene-2-sulfonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanamide'>GIY</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sh0 OCA], [https://pdbe.org/7sh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7sh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sh0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/ERAP2_HUMAN ERAP2_HUMAN]] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.<ref>PMID:12799365</ref> <ref>PMID:15908954</ref> <ref>PMID:16286653</ref>
		+
		+	==See Also==
		+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bouvier M]]		[[Category: Bouvier M]]
	[[Category: Li L]]		[[Category: Li L]]

OCA at 06:51, 20 July 2022

2022-07-20T06:51:33Z

←Older revision		Revision as of 06:51, 20 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7sh0 ~~is ON HOLD until Paper Publication~~	+	==CRYSTAL STRUCTURE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (ERAP2) COMPLEX WITH A HIGHLY SELECTIVE AND POTENT SMALL MOLECULE==
-		+	<StructureSection load='7sh0' size='340' side='right'caption='[[7sh0]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SH0 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sh0 OCA], [https://pdbe.org/7sh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7sh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sh0 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bouvier M]]
		+	[[Category: Li L]]

OCA at 06:39, 25 May 2022

2022-05-25T06:39:06Z

←Older revision		Revision as of 06:39, 25 May 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sh0 is ON HOLD	+	The entry 7sh0 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7sh0" [edit=sysop:move=sysop]

2021-10-13T10:29:51Z

Protected "7sh0" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:29, 13 October 2021

OCA: New page: '''Unreleased structure''' The entry 7sh0 is ON HOLD Authors: Description: Category: Unreleased Structures

2021-10-13T10:29:50Z

New page: '''Unreleased structure''' The entry 7sh0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7sh0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]