7sqm - Revision history

OCA at 16:54, 18 October 2023

2023-10-18T16:54:12Z

←Older revision		Revision as of 16:54, 18 October 2023
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	==Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cure in Uncomplicated Malaria==		==Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cure in Uncomplicated Malaria==
-	<StructureSection load='7sqm' size='340' side='right'caption='[[7sqm]]' scene=''>	+	<StructureSection load='7sqm' size='340' side='right'caption='[[7sqm]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SQM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7sqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SQM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sqm OCA], [https://pdbe.org/7sqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sqm RCSB], [https://www.ebi.ac.uk/pdbsum/7sqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sqm ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A5G:1-[(4S)-5-(2,4-difluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-4-methylpiperidin-4-amine'>A5G</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sqm OCA], [https://pdbe.org/7sqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sqm RCSB], [https://www.ebi.ac.uk/pdbsum/7sqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sqm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Shu W]]		[[Category: Shu W]]
	[[Category: Yokokawa F]]		[[Category: Yokokawa F]]

OCA at 14:11, 29 December 2021

2021-12-29T14:11:41Z

←Older revision		Revision as of 14:11, 29 December 2021
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-	'''Unreleased structure'''

-	~~The entry 7sqm is ON HOLD~~	+	==Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cure in Uncomplicated Malaria==
-		+	<StructureSection load='7sqm' size='340' side='right'caption='[[7sqm]]' scene=''>
-	~~Authors: Shu, W., Yokokawa, F.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SQM FirstGlance]. <br>
-	~~Description:~~ Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cure in Uncomplicated Malaria	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sqm OCA], [https://pdbe.org/7sqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sqm RCSB], [https://www.ebi.ac.uk/pdbsum/7sqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sqm ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Shu, W]]	+	__TOC__
-	[[Category: Yokokawa, F]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Shu W]]
		+	[[Category: Yokokawa F]]

OCA: Protected "7sqm" [edit=sysop:move=sysop]

2021-11-17T12:13:16Z

Protected "7sqm" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:13, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7sqm is ON HOLD Authors: Shu, W., Yokokawa, F. Description: Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage ...

2021-11-17T12:13:15Z

New page: '''Unreleased structure''' The entry 7sqm is ON HOLD Authors: Shu, W., Yokokawa, F. Description: Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage ...

New page

'''Unreleased structure'''

The entry 7sqm is ON HOLD

Authors: Shu, W., Yokokawa, F.

Description: Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cure in Uncomplicated Malaria
[[Category: Unreleased Structures]]
[[Category: Shu, W]]
[[Category: Yokokawa, F]]