7tmx - Revision history

OCA at 10:32, 2 August 2023

2023-08-02T10:32:28Z

←Older revision		Revision as of 10:32, 2 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7tmx is ~~ON HOLD until Paper Publication~~	+	==Structure of Mouse Importin alpha NEIL1 NLS Peptide Complex==
-		+	<StructureSection load='7tmx' size='340' side='right'caption='[[7tmx]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~: ~~Moraes~~, I.R., ~~de Oliveira~~, H.C., ~~Fontes, M~~.R.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7tmx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TMX FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~Mouse Importin~~ alpha ~~NEIL1 NLS Peptide Complex~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tmx OCA], [https://pdbe.org/7tmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tmx RCSB], [https://www.ebi.ac.uk/pdbsum/7tmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tmx ProSAT]</span></td></tr>
-	[[Category: ~~De Oliveira, H.C~~]]	+	</table>
-	[[Category: Fontes~~, M.R.M~~]]	+	== Function ==
-	[[Category: Moraes~~, I.R~~]]	+	[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Fontes MRM]]
		+	[[Category: Moraes IR]]
		+	[[Category: De Oliveira HC]]

OCA at 02:16, 25 May 2023

2023-05-25T02:16:59Z

←Older revision		Revision as of 02:16, 25 May 2023
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	The entry 7tmx is ON HOLD until Paper Publication		The entry 7tmx is ON HOLD until Paper Publication

-	Authors: Moraes, I.R., de Oliveira, H~~.C., de Barros, A~~.C., Fontes, M.R.M.	+	Authors: Moraes, I.R., de Oliveira, H.C., Fontes, M.R.M.

	Description: Structure of Mouse Importin alpha NEIL1 NLS Peptide Complex		Description: Structure of Mouse Importin alpha NEIL1 NLS Peptide Complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: De Barros, A.C]]
-	[[Category: Moraes, I.R]]
	[[Category: De Oliveira, H.C]]		[[Category: De Oliveira, H.C]]
	[[Category: Fontes, M.R.M]]		[[Category: Fontes, M.R.M]]
		+	[[Category: Moraes, I.R]]

OCA at 04:52, 9 March 2022

2022-03-09T04:52:11Z

←Older revision		Revision as of 04:52, 9 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7tmx is ON HOLD	+	The entry 7tmx is ON HOLD until Paper Publication

	Authors: Moraes, I.R., de Oliveira, H.C., de Barros, A.C., Fontes, M.R.M.		Authors: Moraes, I.R., de Oliveira, H.C., de Barros, A.C., Fontes, M.R.M.

OCA: Protected "7tmx" [edit=sysop:move=sysop]

2022-01-27T05:36:51Z

Protected "7tmx" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 27 January 2022

OCA: New page: '''Unreleased structure''' The entry 7tmx is ON HOLD Authors: Moraes, I.R., de Oliveira, H.C., de Barros, A.C., Fontes, M.R.M. Description: Structure of Mouse Importin alpha NEIL1 NLS ...

2022-01-27T05:36:50Z

New page: '''Unreleased structure''' The entry 7tmx is ON HOLD Authors: Moraes, I.R., de Oliveira, H.C., de Barros, A.C., Fontes, M.R.M. Description: Structure of Mouse Importin alpha NEIL1 NLS ...

New page

'''Unreleased structure'''

The entry 7tmx is ON HOLD

Authors: Moraes, I.R., de Oliveira, H.C., de Barros, A.C., Fontes, M.R.M.

Description: Structure of Mouse Importin alpha NEIL1 NLS Peptide Complex
[[Category: Unreleased Structures]]
[[Category: De Barros, A.C]]
[[Category: Moraes, I.R]]
[[Category: De Oliveira, H.C]]
[[Category: Fontes, M.R.M]]