7tsd - Revision history

OCA at 17:07, 18 October 2023

2023-10-18T17:07:29Z

←Older revision		Revision as of 17:07, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7tsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K7U:6-[3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl]-4-methylpyridin-2-amine'>K7U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.769Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K7U:6-[3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl]-4-methylpyridin-2-amine'>K7U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsd OCA], [https://pdbe.org/7tsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsd RCSB], [https://www.ebi.ac.uk/pdbsum/7tsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsd OCA], [https://pdbe.org/7tsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsd RCSB], [https://www.ebi.ac.uk/pdbsum/7tsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.	+	[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:51, 8 September 2022

2022-09-08T05:51:21Z

←Older revision		Revision as of 05:51, 8 September 2022
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	==Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine==		==Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine==
-	<StructureSection load='7tsd' size='340' side='right'caption='[[7tsd]]' scene=''>	+	<StructureSection load='7tsd' size='340' side='right'caption='[[7tsd]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7tsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsd OCA], [https://pdbe.org/7tsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsd RCSB], [https://www.ebi.ac.uk/pdbsum/7tsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsd ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K7U:6-[3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl]-4-methylpyridin-2-amine'>K7U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsd OCA], [https://pdbe.org/7tsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsd RCSB], [https://www.ebi.ac.uk/pdbsum/7tsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Rattus norvegicus]]
	[[Category: Li H]]		[[Category: Li H]]
	[[Category: Poulos TL]]		[[Category: Poulos TL]]

OCA at 05:17, 13 July 2022

2022-07-13T05:17:34Z

←Older revision		Revision as of 05:17, 13 July 2022
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-	'''Unreleased structure'''

-	~~The entry 7tsd is ON HOLD until Paper Publication~~	+	==Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine==
-		+	<StructureSection load='7tsd' size='340' side='right'caption='[[7tsd]]' scene=''>
-	~~Authors: Li, H., Poulos, T.L.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TSD FirstGlance]. <br>
-	~~Description:~~ Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tsd OCA], [https://pdbe.org/7tsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tsd RCSB], [https://www.ebi.ac.uk/pdbsum/7tsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tsd ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Li, H]]	+	__TOC__
-	[[Category: Poulos~~, T.L~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li H]]
		+	[[Category: Poulos TL]]

OCA at 09:08, 16 February 2022

2022-02-16T09:08:35Z

←Older revision		Revision as of 09:08, 16 February 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7tsd is ON HOLD	+	The entry 7tsd is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

-	Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine	+	Description: Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Poulos, T.L]]		[[Category: Poulos, T.L]]

OCA: Protected "7tsd" [edit=sysop:move=sysop]

2022-02-09T06:19:28Z

Protected "7tsd" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:19, 9 February 2022

OCA: New page: '''Unreleased structure''' The entry 7tsd is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3,3-di...

2022-02-09T06:19:27Z

New page: '''Unreleased structure''' The entry 7tsd is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3,3-di...

New page

'''Unreleased structure'''

The entry 7tsd is ON HOLD

Authors: Li, H., Poulos, T.L.

Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine
[[Category: Unreleased Structures]]
[[Category: Li, H]]
[[Category: Poulos, T.L]]