7tzb - Revision history

OCA at 17:09, 18 October 2023

2023-10-18T17:09:22Z

←Older revision		Revision as of 17:09, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7tzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzb OCA], [https://pdbe.org/7tzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzb RCSB], [https://www.ebi.ac.uk/pdbsum/7tzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzb OCA], [https://pdbe.org/7tzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzb RCSB], [https://www.ebi.ac.uk/pdbsum/7tzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SYSM_HUMAN SYSM_HUMAN]] Hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/SYSM_HUMAN SYSM_HUMAN] Hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SYSM_HUMAN SYSM_HUMAN]] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).[UniProtKB:Q9N0F3]	+	[https://www.uniprot.org/uniprot/SYSM_HUMAN SYSM_HUMAN] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).[UniProtKB:Q9N0F3]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:55, 14 September 2022

2022-09-14T06:55:51Z

←Older revision		Revision as of 06:55, 14 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7tzb is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the human mitochondrial seryl-tRNA synthetase (mt SerRS) bound with a seryl-adenylate analogue==
		+	<StructureSection load='7tzb' size='340' side='right'caption='[[7tzb]], [[Resolution\|resolution]] 2.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7tzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SSA:5-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE'>SSA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzb OCA], [https://pdbe.org/7tzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzb RCSB], [https://www.ebi.ac.uk/pdbsum/7tzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzb ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/SYSM_HUMAN SYSM_HUMAN]] Hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SYSM_HUMAN SYSM_HUMAN]] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).[UniProtKB:Q9N0F3]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human mitochondrial gene expression relies on the specific recognition and aminoacylation of mitochondrial tRNAs (mtRNAs) by nuclear-encoded mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs). Despite their essential role in cellular energy homeostasis, strong mutation pressure and genetic drift have led to an unparalleled sequence erosion of animal mtRNAs. The structural and functional consequences of this erosion are not understood. Here, we present cryo-EM structures of the human mitochondrial seryl-tRNA synthetase (mSerRS) in complex with mtRNA(Ser(GCU)). These structures reveal a unique mechanism of substrate recognition and aminoacylation. The mtRNA(Ser(GCU)) is highly degenerated, having lost the entire D-arm, tertiary core, and stable L-shaped fold that define canonical tRNAs. Instead, mtRNA(Ser(GCU)) evolved unique structural innovations, including a radically altered T-arm topology that serves as critical identity determinant in an unusual shape-selective readout mechanism by mSerRS. Our results provide a molecular framework to understand the principles of mito-nuclear co-evolution and specialized mechanisms of tRNA recognition in mammalian mitochondrial gene expression.

-	~~Authors~~:	+	Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.,Kuhle B, Hirschi M, Doerfel LK, Lander GC, Schimmel P Nat Commun. 2022 Aug 30;13(1):5100. doi: 10.1038/s41467-022-32544-1. PMID:36042193<ref>PMID:36042193</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7tzb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Doerfel L]]
		+	[[Category: Hirschi M]]
		+	[[Category: Kuhle B]]
		+	[[Category: Lander G]]
		+	[[Category: Schimmel P]]

OCA at 09:47, 23 March 2022

2022-03-23T09:47:16Z

←Older revision		Revision as of 09:47, 23 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7tzb is ON HOLD	+	The entry 7tzb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7tzb" [edit=sysop:move=sysop]

2022-02-23T06:34:15Z

Protected "7tzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:34, 23 February 2022

OCA: New page: '''Unreleased structure''' The entry 7tzb is ON HOLD Authors: Description: Category: Unreleased Structures

2022-02-23T06:34:14Z

New page: '''Unreleased structure''' The entry 7tzb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7tzb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]