7u4v - Revision history

OCA: Replacing page with 'REMOVED: The PDB entry 7u4v was removed.'

2023-04-07T06:20:47Z

Replacing page with 'REMOVED: The PDB entry 7u4v was removed.'

←Older revision		Revision as of 06:20, 7 April 2023
Line 1:		Line 1:
-		+	REMOVED: The PDB entry 7u4v was removed.
-	==CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(2H)METHYLPYRIDAZINE-3-CARBOXAMIDE==	+
-	~~<StructureSection load='7u4v' size='340' side='right'caption='[[7u4v]], [[Resolution\|resolution]] 3.04Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[7u4v]] is a 2 chain structure with sequence from [https~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4V FirstGlance]. <br>	+
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZN:6-[(cyclopropanecarbonyl)amino]-4-{[(4M)-3-methoxy-4-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl]amino}-N-methylpyridazine-3-carboxamide'>LZN</scene></td></tr>	+
-	~~<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=~~7u4v ~~FirstGlance], [http://oca~~.weizmann.ac.il/oca-bin/ocaids?id=7u4v OCA], [https://pdbe.org/7u4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4v RCSB], [https://www.ebi.ac.uk/pdbsum/7u4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4v ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Disease ==~~	+
-	[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.	+
-	~~== Function ==~~	+
-	[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Homo sapiens]]~~	+
-	~~[[Category: Large Structures]]~~	+
-	~~[[Category: Khan JA]]~~	+

OCA at 07:14, 22 March 2023

2023-03-22T07:14:49Z

←Older revision		Revision as of 07:14, 22 March 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7u4v is ON HOLD until Paper Publication~~	+	==CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(2H)METHYLPYRIDAZINE-3-CARBOXAMIDE==
-		+	<StructureSection load='7u4v' size='340' side='right'caption='[[7u4v]], [[Resolution\|resolution]] 3.04Å' scene=''>
-	~~Authors: Khan, J.A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7u4v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4V FirstGlance]. <br>
-	~~Description:~~ CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(2H)METHYLPYRIDAZINE-3-CARBOXAMIDE	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZN:6-[(cyclopropanecarbonyl)amino]-4-{[(4M)-3-methoxy-4-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl]amino}-N-methylpyridazine-3-carboxamide'>LZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4v OCA], [https://pdbe.org/7u4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4v RCSB], [https://www.ebi.ac.uk/pdbsum/7u4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4v ProSAT]</span></td></tr>
-	[[Category: Khan~~, J.A~~]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Khan JA]]

OCA at 03:49, 8 June 2022

2022-06-08T03:49:52Z

←Older revision		Revision as of 03:49, 8 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7u4v is ON HOLD	+	The entry 7u4v is ON HOLD until Paper Publication

	Authors: Khan, J.A.		Authors: Khan, J.A.

OCA at 05:01, 16 March 2022

2022-03-16T05:01:49Z

←Older revision		Revision as of 05:01, 16 March 2022
Line 5:		Line 5:
	Authors: Khan, J.A.		Authors: Khan, J.A.

-	Description: CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(~~?H?~~)METHYLPYRIDAZINE-3-~~CA RBOXAMIDE~~	+	Description: CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(2H)METHYLPYRIDAZINE-3-CARBOXAMIDE
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Khan, J.A]]		[[Category: Khan, J.A]]

OCA: Protected "7u4v" [edit=sysop:move=sysop]

2022-03-09T04:57:38Z

Protected "7u4v" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 9 March 2022

OCA: New page: '''Unreleased structure''' The entry 7u4v is ON HOLD Authors: Khan, J.A. Description: CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCL...

2022-03-09T04:57:37Z

New page: '''Unreleased structure''' The entry 7u4v is ON HOLD Authors: Khan, J.A. Description: CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCL...

New page

'''Unreleased structure'''

The entry 7u4v is ON HOLD

Authors: Khan, J.A.

Description: CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED COMPOUND-2d AKA 6-CYCLOPROPANEAMIDO-4-{[3-METHOXY-4-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PYRIDIN-2-YL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CA RBOXAMIDE
[[Category: Unreleased Structures]]
[[Category: Khan, J.A]]