7u5v - Revision history

OCA at 06:50, 27 September 2023

2023-09-27T06:50:31Z

←Older revision		Revision as of 06:50, 27 September 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7u5v is ~~ON HOLD until 2024~~-~~09-30~~	+	==Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide==
-		+	<StructureSection load='7u5v' size='340' side='right'caption='[[7u5v]], [[Resolution\|resolution]] 2.59Å' scene=''>
-	~~Authors~~: An, S~~., Cho~~, U.S., ~~Oh, H~~., ~~Sha, L~~., ~~Xu, J~~., ~~Kim, S~~., ~~Yang, W~~., An, W., ~~Dou~~, Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7u5v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U5V FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of the ~~Mixed Lineage Leukaemia (~~MLL1) ~~SET Domain with the cofactor product S~~-~~Adenosylhomocysteine~~ and ~~Borealin peptide~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.59Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Cho, U.~~S]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u5v OCA], [https://pdbe.org/7u5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u5v RCSB], [https://www.ebi.ac.uk/pdbsum/7u5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u5v ProSAT]</span></td></tr>
-	[[Category: An~~, S~~]]	+	</table>
-	[[Category: ~~Kim, S~~]]	+	== Disease ==
-	[[Category: ~~Oh, H~~]]	+	[https://www.uniprot.org/uniprot/KMT2A_HUMAN KMT2A_HUMAN] Acute myeloid leukemia with 11q23 abnormalities;Precursor B-cell acute lymphoblastic leukemia;Wiedemann-Steiner syndrome;Acute biphenotypic leukemia;Acute undifferentiated leukemia;Bilineal acute leukemia. The disease is caused by mutations affecting the gene represented in this entry. Chromosomal aberrations involving KMT2A are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins KMT2A-MLLT1, KMT2A-MLLT3 and KMT2A-ELL interact with PPP1R15A and, on the contrary to unfused KMT2A, inhibit PPP1R15A-induced apoptosis. A chromosomal aberration involving KMT2A may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11.
-	[[Category: ~~An, W~~]]	+	== Function ==
-	[[Category: ~~Yang, W~~]]	+	[https://www.uniprot.org/uniprot/KMT2A_HUMAN KMT2A_HUMAN] Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.<ref>PMID:10490642</ref> <ref>PMID:12453419</ref> <ref>PMID:15960975</ref> <ref>PMID:19556245</ref>
-	[[Category: Sha, L]]	+	== References ==
-	[[Category: Xu, J]]	+	<references/>
-	[[Category: ~~Dou, Y~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: An S]]
		+	[[Category: An W]]
		+	[[Category: Cho US]]
		+	[[Category: Dou Y]]
		+	[[Category: Kim S]]
		+	[[Category: Oh H]]
		+	[[Category: Sha L]]
		+	[[Category: Xu J]]
		+	[[Category: Yang W]]

OCA at 04:48, 8 February 2023

2023-02-08T04:48:37Z

←Older revision		Revision as of 04:48, 8 February 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7u5v is ON HOLD until 2024-03-02	+	The entry 7u5v is ON HOLD until 2024-09-30

	Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y.		Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y.
Line 7:		Line 7:
	Description: Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide		Description: Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: An, W]]
	[[Category: Cho, U.S]]		[[Category: Cho, U.S]]
	[[Category: An, S]]		[[Category: An, S]]
-	[[Category: Oh, H]]
	[[Category: Kim, S]]		[[Category: Kim, S]]
-	[[Category: Xu, J]]	+	[[Category: Oh, H]]
-	[[Category: ~~Dou~~, Y]]	+	[[Category: An, W]]
	[[Category: Yang, W]]		[[Category: Yang, W]]
	[[Category: Sha, L]]		[[Category: Sha, L]]
		+	[[Category: Xu, J]]
		+	[[Category: Dou, Y]]

OCA at 06:42, 22 June 2022

2022-06-22T06:42:16Z

←Older revision		Revision as of 06:42, 22 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7u5v is ON HOLD until ~~Mar 02~~ 2024	+	The entry 7u5v is ON HOLD until 2024-03-02

	Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y.		Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y.
Line 7:		Line 7:
	Description: Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide		Description: Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Kim, S]]
	[[Category: An, W]]		[[Category: An, W]]
-	[[Category: Xu, J]]
-	[[Category: Dou, Y]]
	[[Category: Cho, U.S]]		[[Category: Cho, U.S]]
	[[Category: An, S]]		[[Category: An, S]]
	[[Category: Oh, H]]		[[Category: Oh, H]]
		+	[[Category: Kim, S]]
		+	[[Category: Xu, J]]
		+	[[Category: Dou, Y]]
	[[Category: Yang, W]]		[[Category: Yang, W]]
	[[Category: Sha, L]]		[[Category: Sha, L]]

OCA at 08:32, 13 April 2022

2022-04-13T08:32:27Z

←Older revision		Revision as of 08:32, 13 April 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7u5v is ON HOLD	+	The entry 7u5v is ON HOLD until Mar 02 2024

	Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y.		Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y.
Line 7:		Line 7:
	Description: Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide		Description: Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Kim, S]]
	[[Category: An, W]]		[[Category: An, W]]
		+	[[Category: Xu, J]]
		+	[[Category: Dou, Y]]
	[[Category: Cho, U.S]]		[[Category: Cho, U.S]]
	[[Category: An, S]]		[[Category: An, S]]
	[[Category: Oh, H]]		[[Category: Oh, H]]
-	[[Category: Kim, S]]
-	[[Category: Xu, J]]
-	[[Category: Dou, Y]]
	[[Category: Yang, W]]		[[Category: Yang, W]]
	[[Category: Sha, L]]		[[Category: Sha, L]]

OCA: Protected "7u5v" [edit=sysop:move=sysop]

2022-03-09T04:59:08Z

Protected "7u5v" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:59, 9 March 2022

OCA: New page: '''Unreleased structure''' The entry 7u5v is ON HOLD Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y. Description: Crystal structure of the Mixed...

2022-03-09T04:59:07Z

New page: '''Unreleased structure''' The entry 7u5v is ON HOLD Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y. Description: Crystal structure of the Mixed...

New page

'''Unreleased structure'''

The entry 7u5v is ON HOLD

Authors: An, S., Cho, U.S., Oh, H., Sha, L., Xu, J., Kim, S., Yang, W., An, W., Dou, Y.

Description: Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide
[[Category: Unreleased Structures]]
[[Category: An, W]]
[[Category: Cho, U.S]]
[[Category: An, S]]
[[Category: Oh, H]]
[[Category: Kim, S]]
[[Category: Xu, J]]
[[Category: Dou, Y]]
[[Category: Yang, W]]
[[Category: Sha, L]]