7uof - Revision history

OCA at 09:55, 25 October 2023

2023-10-25T09:55:29Z

←Older revision		Revision as of 09:55, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7uof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UOF FirstGlance]. <br>		<table><tr><td colspan='2'>[[7uof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UOF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uof OCA], [https://pdbe.org/7uof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uof RCSB], [https://www.ebi.ac.uk/pdbsum/7uof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uof ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uof OCA], [https://pdbe.org/7uof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uof RCSB], [https://www.ebi.ac.uk/pdbsum/7uof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uof ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 7uof" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7uof" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydroorotase 3D structures\|Dihydroorotase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:15, 28 December 2022

2022-12-28T09:15:39Z

←Older revision		Revision as of 09:15, 28 December 2022
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	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PYRC_METJA PYRC_METJA]] Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.	+	[https://www.uniprot.org/uniprot/PYRC_METJA PYRC_METJA] Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 19:28, 7 September 2022

2022-09-07T19:28:09Z

←Older revision		Revision as of 19:28, 7 September 2022
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	==Dihydroorotase from M. jannaschii==		==Dihydroorotase from M. jannaschii==
-	<StructureSection load='7uof' size='340' side='right'caption='[[7uof]]' scene=''>	+	<StructureSection load='7uof' size='340' side='right'caption='[[7uof]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UOF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7uof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UOF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uof OCA], [https://pdbe.org/7uof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uof RCSB], [https://www.ebi.ac.uk/pdbsum/7uof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uof ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uof OCA], [https://pdbe.org/7uof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uof RCSB], [https://www.ebi.ac.uk/pdbsum/7uof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uof ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/PYRC_METJA PYRC_METJA]] Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In this paper, we report the structural analysis of dihydroorotase (DHOase) from the hyperthermophilic and barophilic archaeon Methanococcus jannaschii. DHOase catalyzes the reversible cyclization of N-carbamoyl-l-aspartate to l-dihydroorotate in the third step of de novo pyrimidine biosynthesis. DHOases form a very diverse family of enzymes and have been classified into types and subtypes with structural similarities and differences among them. This is the first archaeal DHOase studied by x-ray diffraction. Its structure and comparison with known representatives of the other subtypes help define the structural features of the archaeal subtype. The M. jannaschii DHOase is found here to have traits from all subtypes. Contrary to expectations, it has a carboxylated lysine bridging the two Zn ions in the active site, and a long catalytic loop. It is a monomeric protein with a large beta sandwich domain adjacent to the TIM barrel. Loop 5 is similar to bacterial type III and the C-terminal extension is long.
		+
		+	Crystal structure of Methanococcus jannaschii dihydroorotase.,Vitali J, Nix JC, Newman HE, Colaneri MJ Proteins. 2022 Aug 17. doi: 10.1002/prot.26412. PMID:35978488<ref>PMID:35978488</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7uof" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Methanocaldococcus jannaschii]]
	[[Category: Colaneri MJ]]		[[Category: Colaneri MJ]]
	[[Category: Newman HE]]		[[Category: Newman HE]]
	[[Category: Nix JC]]		[[Category: Nix JC]]
	[[Category: Vitali J]]		[[Category: Vitali J]]

OCA at 06:37, 31 August 2022

2022-08-31T06:37:23Z

←Older revision		Revision as of 06:37, 31 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7uof ~~is ON HOLD until Paper Publication~~	+	==Dihydroorotase from M. jannaschii==
-		+	<StructureSection load='7uof' size='340' side='right'caption='[[7uof]]' scene=''>
-	~~Authors~~: ~~Vitali~~, J., ~~Nix~~, J.C., ~~Newman, H~~.E., ~~Colaneri, M~~.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UOF FirstGlance]. <br>
-	~~Description: Dihydroorotase from M. jannaschii~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uof OCA], [https://pdbe.org/7uof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uof RCSB], [https://www.ebi.ac.uk/pdbsum/7uof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uof ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Newman, H.E~~]]	+	__TOC__
-	[[Category: ~~Nix, J.C~~]]	+	</StructureSection>
-	[[Category: ~~Vitali, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Colaneri, M.~~J]]	+	[[Category: Colaneri MJ]]
		+	[[Category: Newman HE]]
		+	[[Category: Nix JC]]
		+	[[Category: Vitali J]]

OCA at 04:46, 12 May 2022

2022-05-12T04:46:10Z

←Older revision		Revision as of 04:46, 12 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7uof is ON HOLD	+	The entry 7uof is ON HOLD until Paper Publication

	Authors: Vitali, J., Nix, J.C., Newman, H.E., Colaneri, M.J.		Authors: Vitali, J., Nix, J.C., Newman, H.E., Colaneri, M.J.

OCA: Protected "7uof" [edit=sysop:move=sysop]

2022-04-21T01:37:02Z

Protected "7uof" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:37, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7uof is ON HOLD Authors: Vitali, J., Nix, J.C., Newman, H.E., Colaneri, M.J. Description: Dihydroorotase from M. jannaschii [[Category: Unreleased ...

2022-04-21T01:37:00Z

New page: '''Unreleased structure''' The entry 7uof is ON HOLD Authors: Vitali, J., Nix, J.C., Newman, H.E., Colaneri, M.J. Description: Dihydroorotase from M. jannaschii [[Category: Unreleased ...

New page

'''Unreleased structure'''

The entry 7uof is ON HOLD

Authors: Vitali, J., Nix, J.C., Newman, H.E., Colaneri, M.J.

Description: Dihydroorotase from M. jannaschii
[[Category: Unreleased Structures]]
[[Category: Newman, H.E]]
[[Category: Nix, J.C]]
[[Category: Vitali, J]]
[[Category: Colaneri, M.J]]