7uso - Revision history

OCA at 17:20, 18 October 2023

2023-10-18T17:20:20Z

←Older revision		Revision as of 17:20, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7uso]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7USO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7USO FirstGlance]. <br>		<table><tr><td colspan='2'>[[7uso]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7USO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7USO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uso OCA], [https://pdbe.org/7uso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uso RCSB], [https://www.ebi.ac.uk/pdbsum/7uso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uso ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uso OCA], [https://pdbe.org/7uso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uso RCSB], [https://www.ebi.ac.uk/pdbsum/7uso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uso ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>	+	[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7uso" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7uso" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:04, 14 September 2022

2022-09-14T07:04:25Z

←Older revision		Revision as of 07:04, 14 September 2022
Line 1:		Line 1:

-	====	+	==Crystal Structure of Caspase-3 with Peptide Inhibitor AcITVKD-CHO==
-	<StructureSection load='7uso' size='340' side='right'caption='[[7uso]]' scene=''>	+	<StructureSection load='7uso' size='340' side='right'caption='[[7uso]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7uso]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7USO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7USO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uso OCA], [https://pdbe.org/7uso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uso RCSB], [https://www.ebi.ac.uk/pdbsum/7uso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uso ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uso OCA], [https://pdbe.org/7uso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uso RCSB], [https://www.ebi.ac.uk/pdbsum/7uso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uso ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Since the discovery of the caspase-2 (Casp2)-mediated tau314 cleavage product and its associated impact on tauopathies such as Alzheimer's disease, the design of selective Casp2 inhibitors has become a focus in medicinal chemistry research. In the search for new lead structures with respect to Casp2 selectivity and drug-likeness, we have taken an approach by looking more closely at the specific sites of Casp2-mediated proteolysis. Using seven selected protein cleavage sequences, we synthesized a peptide series of 53 novel molecules and studied them using in vitro pharmacology, molecular modeling, and crystallography. Regarding Casp2 selectivity, AcITV(Dab)D-CHO (23) and AcITV(Dap)D-CHO (26) demonstrated the best selectivity (1-6-fold), although these trends were only moderate. However, some analogous tetrapeptides, most notably AcDKVD-CHO (45), showed significantly increased Casp3 selectivities (>100-fold). Tetra- and tripeptides display decreased or no Casp2 affinity, supporting the assumption that a motif of five amino acids is required for efficient Casp2 inhibition. Overall, the results provide a reasonable basis for the development of both selective Casp2 and Casp3 inhibitors.
		+
		+	Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis.,Bresinsky M, Strasser JM, Hubmann A, Vallaster B, McCue WM, Fuller J, Singh G, Nelson KM, Cuellar ME, Finzel BC, Ashe KH, Walters MA, Pockes S Arch Pharm (Weinheim). 2022 Sep;355(9):e2200095. doi: 10.1002/ardp.202200095., Epub 2022 May 31. PMID:35642311<ref>PMID:35642311</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7uso" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Finzel BC]]
		+	[[Category: Fuller JL]]

OCA at 05:22, 15 June 2022

2022-06-15T05:22:49Z

←Older revision		Revision as of 05:22, 15 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7uso ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7uso' size='340' side='right'caption='[[7uso]]' scene=''>
-	~~Authors~~: ~~Fuller, J~~.L.~~, Finzel, B~~.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Caspase~~-~~3 with Peptide Inhibitor AcITVKD-CHO~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uso OCA], [https://pdbe.org/7uso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uso RCSB], [https://www.ebi.ac.uk/pdbsum/7uso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uso ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Finzel, B.C~~]]	+	__TOC__
-	[[Category: ~~Fuller, J.L~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7uso" [edit=sysop:move=sysop]

2022-05-04T11:33:10Z

Protected "7uso" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:33, 4 May 2022

OCA: New page: '''Unreleased structure''' The entry 7uso is ON HOLD Authors: Fuller, J.L., Finzel, B.C. Description: Crystal Structure of Caspase-3 with Peptide Inhibitor AcITVKD-CHO [[Category: Unre...

2022-05-04T11:33:09Z

New page: '''Unreleased structure''' The entry 7uso is ON HOLD Authors: Fuller, J.L., Finzel, B.C. Description: Crystal Structure of Caspase-3 with Peptide Inhibitor AcITVKD-CHO [[Category: Unre...

New page

'''Unreleased structure'''

The entry 7uso is ON HOLD

Authors: Fuller, J.L., Finzel, B.C.

Description: Crystal Structure of Caspase-3 with Peptide Inhibitor AcITVKD-CHO
[[Category: Unreleased Structures]]
[[Category: Finzel, B.C]]
[[Category: Fuller, J.L]]