7uwn - Revision history

OCA at 18:58, 7 September 2022

2022-09-07T18:58:49Z

←Older revision		Revision as of 18:58, 7 September 2022
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	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.		[[https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The IL-17 family of cytokines and receptors have central roles in host defence against infection and development of inflammatory diseases(1). The compositions and structures of functional IL-17 family ligand-receptor signalling assemblies remain unclear. IL-17E (also known as IL-25) is a key regulator of type 2 immune responses and driver of inflammatory diseases, such as allergic asthma, and requires both IL-17 receptor A (IL-17RA) and IL-17RB to elicit functional responses(2). Here we studied IL-25-IL-17RB binary and IL-25-IL-17RB-IL-17RA ternary complexes using a combination of cryo-electron microscopy, single-molecule imaging and cell-based signalling approaches. The IL-25-IL-17RB-IL-17RA ternary signalling assembly is a C2-symmetric complex in which the IL-25-IL-17RB homodimer is flanked by two 'wing-like' IL-17RA co-receptors through a 'tip-to-tip' geometry that is the key receptor-receptor interaction required for initiation of signal transduction. IL-25 interacts solely with IL-17RB to allosterically promote the formation of the IL-17RB-IL-17RA tip-to-tip interface. The resulting large separation between the receptors at the membrane-proximal level may reflect proximity constraints imposed by the intracellular domains for signalling. Cryo-electron microscopy structures of IL-17A-IL-17RA and IL-17A-IL-17RA-IL-17RC complexes reveal that this tip-to-tip architecture is a key organizing principle of the IL-17 receptor family. Furthermore, these studies reveal dual actions for IL-17RA sharing among IL-17 cytokine complexes, by either directly engaging IL-17 cytokines or alternatively functioning as a co-receptor.
		+
		+	Organizing structural principles of the IL-17 ligand-receptor axis.,Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC Nature. 2022 Jul 21. pii: 10.1038/s41586-022-05116-y. doi:, 10.1038/s41586-022-05116-y. PMID:35863378<ref>PMID:35863378</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7uwn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:49, 7 September 2022

2022-09-07T16:49:35Z

←Older revision		Revision as of 16:49, 7 September 2022
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-	====	+	==Structure of the IL-17A-IL-17RA-IL-17RC ternary complex==
-	<StructureSection load='7uwn' size='340' side='right'caption='[[7uwn]]' scene=''>	+	<StructureSection load='7uwn' size='340' side='right'caption='[[7uwn]], [[Resolution\|resolution]] 3.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7uwn]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UWN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uwn OCA], [https://pdbe.org/7uwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uwn RCSB], [https://www.ebi.ac.uk/pdbsum/7uwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uwn ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uwn OCA], [https://pdbe.org/7uwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uwn RCSB], [https://www.ebi.ac.uk/pdbsum/7uwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uwn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Caveney NA]]
		+	[[Category: Garcia KC]]
		+	[[Category: Jude KM]]
		+	[[Category: Wilson SC]]

OCA at 18:05, 27 July 2022

2022-07-27T18:05:50Z

←Older revision		Revision as of 18:05, 27 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7uwn ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7uwn' size='340' side='right'caption='[[7uwn]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uwn OCA], [https://pdbe.org/7uwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uwn RCSB], [https://www.ebi.ac.uk/pdbsum/7uwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uwn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 03:53, 8 June 2022

2022-06-08T03:53:32Z

←Older revision		Revision as of 03:53, 8 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7uwn is ON HOLD	+	The entry 7uwn is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7uwn" [edit=sysop:move=sysop]

2022-05-12T04:50:17Z

Protected "7uwn" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:50, 12 May 2022

OCA: New page: '''Unreleased structure''' The entry 7uwn is ON HOLD Authors: Description: Category: Unreleased Structures

2022-05-12T04:50:16Z

New page: '''Unreleased structure''' The entry 7uwn is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7uwn is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]