OCA at 06:46, 8 September 2022

2022-09-08T06:46:54Z

←Older revision		Revision as of 06:46, 8 September 2022
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-	====	+	==Staphylococcus epidermidis RP62a CRISPR tall effector complex with bound ATP==
-	<StructureSection load='7v00' size='340' side='right'caption='[[7v00]]' scene=''>	+	<StructureSection load='7v00' size='340' side='right'caption='[[7v00]], [[Resolution\|resolution]] 3.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7v00]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis_RP62A Staphylococcus epidermidis RP62A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V00 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v00 OCA], [https://pdbe.org/7v00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v00 RCSB], [https://www.ebi.ac.uk/pdbsum/7v00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v00 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v00 OCA], [https://pdbe.org/7v00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v00 RCSB], [https://www.ebi.ac.uk/pdbsum/7v00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v00 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q5HK92_STAEQ Q5HK92_STAEQ]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-associated proteins (Cas) provide many prokaryotes with an adaptive immune system against invading genetic material. Type III CRISPR systems are unique in that they can degrade both RNA and DNA. In response to invading nucleic acids, they produce cyclic oligoadenylates that act as secondary messengers, activating cellular nucleases that aid in the immune response. Here, we present seven single-particle cryo-EM structures of the type III-A Staphylococcus epidermidis CRISPR effector complex. The structures reveal the intact S. epidermidis effector complex in an apo, ATP-bound, cognate target RNA-bound, and non-cognate target RNA-bound states and illustrate how the effector complex binds and presents crRNA. The complexes bound to target RNA capture the type III-A effector complex in a post-RNA cleavage state. The ATP-bound structures give details about how ATP binds to Cas10 to facilitate cyclic oligoadenylate production.
		+
		+	Structures of an active type III-A CRISPR effector complex.,Smith EM, Ferrell S, Tokars VL, Mondragon A Structure. 2022 Aug 4;30(8):1109-1128.e6. doi: 10.1016/j.str.2022.05.013. Epub, 2022 Jun 16. PMID:35714601<ref>PMID:35714601</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7v00" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Staphylococcus epidermidis RP62A]]
		+	[[Category: Ferrell SH]]
		+	[[Category: Mondragon A]]
		+	[[Category: Smith EM]]
		+	[[Category: Tokars VL]]

OCA at 16:14, 6 July 2022

2022-07-06T16:14:59Z

←Older revision		Revision as of 16:14, 6 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7v00 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7v00' size='340' side='right'caption='[[7v00]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v00 OCA], [https://pdbe.org/7v00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v00 RCSB], [https://www.ebi.ac.uk/pdbsum/7v00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v00 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:04, 29 June 2022

2022-06-29T06:04:12Z

←Older revision		Revision as of 06:04, 29 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7v00 is ON HOLD	+	The entry 7v00 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7v00" [edit=sysop:move=sysop]

2022-05-18T09:05:51Z

Protected "7v00" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:05, 18 May 2022

OCA: New page: '''Unreleased structure''' The entry 7v00 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-05-18T09:05:50Z

New page: '''Unreleased structure''' The entry 7v00 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7v00 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7v00 - Revision history

OCA at 06:46, 8 September 2022

OCA at 16:14, 6 July 2022

OCA at 06:04, 29 June 2022

OCA: Protected "7v00" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7v00 is ON HOLD Authors: Description: Category: Unreleased Structures