7v4y - Revision history

OCA at 17:20, 29 November 2023

2023-11-29T17:20:20Z

←Older revision		Revision as of 17:20, 29 November 2023
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	==TTHA1264/TTHA1265 complex==		==TTHA1264/TTHA1265 complex==
-	<StructureSection load='7v4y' size='340' side='right'caption='[[7v4y]]' scene=''>	+	<StructureSection load='7v4y' size='340' side='right'caption='[[7v4y]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V4Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7v4y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V4Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v4y OCA], [https://pdbe.org/7v4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v4y RCSB], [https://www.ebi.ac.uk/pdbsum/7v4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v4y ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v4y OCA], [https://pdbe.org/7v4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v4y RCSB], [https://www.ebi.ac.uk/pdbsum/7v4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v4y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5SIU9_THET8 Q5SIU9_THET8]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Zinc peptidase M16 family members are widely distributed in most prokaryotic and eukaryotic organisms. M16 family has been divided into three subfamilies, M16A, M16B and M16C, based on sequence alignments and subunit connectivity. TTHA1264, an M16B protein found in Thermus thermophiles HB8, possesses an HXXEH motif essential for Zn(2+) binding and catalytic activity. TTHA1265 is another member of M16B, which lacks the metal-binding motif but with a conserved active-site R/Y pair commonly found in the C-terminal half of M16 enzymes. Sequence analysis showed that two genes coding for TTHA1264 and TTHA1265 assemble into a single operon in the bacterial genome. Here, we report the crystal structure of TTHA1265 and TTHA1264/TTHA1265 complex from T. thermophilus HB8. Interestingly, when TTHA1264 and TTHA1265 are present alone, TTHA1264 forms a monomer, TTHA1265 forms a homodimer, respectively. However, TTHA264 and TTHA1265 assembled into a heterodimeric complex, indicating that they prefer to form heterodimer. Biochemical data further confirmed the heterodimeric assembly indicating intrinsic heterodimeric assembly of TTHA1264 and TTHA1265. This property of TTHA1264 and TTHA1265 is consistent with the characteristics of the M16B family.
		+
		+	Crystal structures of TTHA1265 and TTHA1264/TTHA1265 complex reveal an intrinsic heterodimeric assembly.,Xu M, Xu Q, Wang M, Qiu S, Xu D, Zhang W, Wang W, He J, Wang Q, Ran T, Sun B Int J Biol Macromol. 2022 May 15;207:424-433. doi: , 10.1016/j.ijbiomac.2022.03.020. Epub 2022 Mar 9. PMID:35276293<ref>PMID:35276293</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7v4y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Xu, M, Xu, Q,~~ Ran, T~~, Wang, W,~~ Sun, B, Wang, Q]]	+	[[Category: Thermus thermophilus HB8]]
		+	[[Category: Ran T]]
		+	[[Category: Sun B]]
		+	[[Category: Wang Q]]
		+	[[Category: Wang W]]
		+	[[Category: Xu M]]
		+	[[Category: Xu Q]]

OCA at 07:28, 29 June 2022

2022-06-29T07:28:11Z

←Older revision		Revision as of 07:28, 29 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7v4y ~~is ON HOLD until Paper Publication~~	+	==TTHA1264/TTHA1265 complex==
-		+	<StructureSection load='7v4y' size='340' side='right'caption='[[7v4y]]' scene=''>
-	~~Authors~~: ~~Xu, M~~.~~, Xu, Q~~.~~, Ran, T~~.~~, Wang, W~~.~~, Sun, B~~.~~, Wang, Q~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V4Y FirstGlance]. <br>
-	~~Description~~: ~~TTHA1264~~/~~TTHA1265 complex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v4y OCA], [https://pdbe.org/7v4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v4y RCSB], [https://www.ebi.ac.uk/pdbsum/7v4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v4y ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures]~~]	+	</table>
-	[[~~Category~~: ~~Wang~~, ~~W]]~~	+	__TOC__
-	[~~[Category~~: ~~Xu, Q]~~]	+	</StructureSection>
-	[~~[Category~~: ~~Sun, B]~~]	+	[[Category: Large Structures]]
-	[~~[Category~~: ~~Ran~~, T]]	+	[[Category: Xu, M, Xu, Q, Ran, T, Wang, W, Sun, B, Wang, Q]]
-	[[Category: ~~Wang, Q~~]]	+
-	[[Category: Xu, M]]	+

OCA at 08:23, 15 September 2021

2021-09-15T08:23:09Z

←Older revision		Revision as of 08:23, 15 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7v4y is ON HOLD	+	The entry 7v4y is ON HOLD until Paper Publication

	Authors: Xu, M., Xu, Q., Ran, T., Wang, W., Sun, B., Wang, Q.		Authors: Xu, M., Xu, Q., Ran, T., Wang, W., Sun, B., Wang, Q.
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	Description: TTHA1264/TTHA1265 complex		Description: TTHA1264/TTHA1265 complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Wang, Q]]
	[[Category: Wang, W]]		[[Category: Wang, W]]
-	[[Category: Xu, M]]
	[[Category: Xu, Q]]		[[Category: Xu, Q]]
	[[Category: Sun, B]]		[[Category: Sun, B]]
	[[Category: Ran, T]]		[[Category: Ran, T]]
		+	[[Category: Wang, Q]]
		+	[[Category: Xu, M]]

OCA: Protected "7v4y" [edit=sysop:move=sysop]

2021-08-25T05:23:43Z

Protected "7v4y" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 25 August 2021

OCA: New page: '''Unreleased structure''' The entry 7v4y is ON HOLD Authors: Xu, M., Xu, Q., Ran, T., Wang, W., Sun, B., Wang, Q. Description: TTHA1264/TTHA1265 complex [[Category: Unreleased Structu...

2021-08-25T05:23:42Z

New page: '''Unreleased structure''' The entry 7v4y is ON HOLD Authors: Xu, M., Xu, Q., Ran, T., Wang, W., Sun, B., Wang, Q. Description: TTHA1264/TTHA1265 complex [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 7v4y is ON HOLD

Authors: Xu, M., Xu, Q., Ran, T., Wang, W., Sun, B., Wang, Q.

Description: TTHA1264/TTHA1265 complex
[[Category: Unreleased Structures]]
[[Category: Wang, Q]]
[[Category: Wang, W]]
[[Category: Xu, M]]
[[Category: Xu, Q]]
[[Category: Sun, B]]
[[Category: Ran, T]]