OCA at 19:21, 19 October 2022

2022-10-19T19:21:42Z

←Older revision		Revision as of 19:21, 19 October 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7vhk ~~is ON HOLD until Paper Publication~~	+	==S1-S2 deletion S-2P trimer(3 down)==
-		+	<StructureSection load='7vhk' size='340' side='right'caption='[[7vhk]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~: ~~Wang~~, X.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7vhk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VHK FirstGlance]. <br>
-	~~Description~~: ~~S1-~~S2 ~~deletion S~~-~~2P trimer~~(~~3 down~~)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vhk OCA], [https://pdbe.org/7vhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vhk RCSB], [https://www.ebi.ac.uk/pdbsum/7vhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vhk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Wang, X]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Cui Z]]
		+	[[Category: Wang X]]

OCA at 05:44, 2 February 2022

2022-02-02T05:44:01Z

←Older revision		Revision as of 05:44, 2 February 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vhk is ON HOLD	+	The entry 7vhk is ON HOLD until Paper Publication

	Authors: Wang, X.		Authors: Wang, X.

OCA at 09:22, 5 January 2022

2022-01-05T09:22:51Z

←Older revision		Revision as of 09:22, 5 January 2022
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	The entry 7vhk is ON HOLD		The entry 7vhk is ON HOLD

-	Authors: ~~Xiangxi~~, W.	+	Authors: Wang, X.

	Description: S1-S2 deletion S-2P trimer(3 down)		Description: S1-S2 deletion S-2P trimer(3 down)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Xiangxi~~, W]]	+	[[Category: Wang, X]]

OCA: Protected "7vhk" [edit=sysop:move=sysop]

2021-09-29T07:53:56Z

Protected "7vhk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:53, 29 September 2021

OCA: New page: '''Unreleased structure''' The entry 7vhk is ON HOLD Authors: Xiangxi, W. Description: S1-S2 deletion S-2P trimer(3 down) Category: Unreleased Structures Category: Xiangxi, W

2021-09-29T07:53:55Z

New page: '''Unreleased structure''' The entry 7vhk is ON HOLD Authors: Xiangxi, W. Description: S1-S2 deletion S-2P trimer(3 down) Category: Unreleased Structures Category: Xiangxi, W

New page

'''Unreleased structure'''

The entry 7vhk is ON HOLD

Authors: Xiangxi, W.

Description: S1-S2 deletion S-2P trimer(3 down)
[[Category: Unreleased Structures]]
[[Category: Xiangxi, W]]

7vhk - Revision history

OCA at 19:21, 19 October 2022

OCA at 05:44, 2 February 2022

OCA at 09:22, 5 January 2022

OCA: Protected "7vhk" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7vhk is ON HOLD Authors: Xiangxi, W. Description: S1-S2 deletion S-2P trimer(3 down) Category: Unreleased Structures Category: Xiangxi, W