7vqa - Revision history

OCA at 17:30, 29 November 2023

2023-11-29T17:30:16Z

←Older revision		Revision as of 17:30, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7vqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_acetivorans_C2A Methanosarcina acetivorans C2A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[7vqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_acetivorans_C2A Methanosarcina acetivorans C2A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VQA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMA:DIMETHYLALLYL+DIPHOSPHATE'>DMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMA:DIMETHYLALLYL+DIPHOSPHATE'>DMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vqa OCA], [https://pdbe.org/7vqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vqa RCSB], [https://www.ebi.ac.uk/pdbsum/7vqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vqa OCA], [https://pdbe.org/7vqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vqa RCSB], [https://www.ebi.ac.uk/pdbsum/7vqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vqa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q8TPS4_METAC Q8TPS4_METAC]]	+	[https://www.uniprot.org/uniprot/Q8TPS4_METAC Q8TPS4_METAC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 19:30, 7 September 2022

2022-09-07T19:30:45Z

←Older revision		Revision as of 19:30, 7 September 2022
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	==Structure of MA1831 from Methanosarcina acetivorans in complex with dimethylallyl diphosphate.==		==Structure of MA1831 from Methanosarcina acetivorans in complex with dimethylallyl diphosphate.==
-	<StructureSection load='7vqa' size='340' side='right'caption='[[7vqa]]' scene=''>	+	<StructureSection load='7vqa' size='340' side='right'caption='[[7vqa]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_acetivorans_C2A Methanosarcina acetivorans C2A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VQA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vqa OCA], [https://pdbe.org/7vqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vqa RCSB], [https://www.ebi.ac.uk/pdbsum/7vqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vqa ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMA:DIMETHYLALLYL+DIPHOSPHATE'>DMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vqa OCA], [https://pdbe.org/7vqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vqa RCSB], [https://www.ebi.ac.uk/pdbsum/7vqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vqa ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q8TPS4_METAC Q8TPS4_METAC]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Isoprenoids represent the largest group of natural products, whose basal skeletons are synthesized by various isoprenyl diphosphate synthases (IDSs). As majority of IDSs catalyze head-to-tail reaction to produce linear form isoprenoids, some catalyze head-to-middle reaction to produce branched form products. In a previous study, an IDS termed MA1831 from Methanosarcina acetivorans was found to be capable of catalyzing both types of reaction. In addition to the canonical linear product of C35 in length, MA1831 also catalyzes head-to-middle condensation of farnesyl diphosphate (FPP) and dimethylallyl diphosphate (DMAPP) to produce geranyllavandulyl diphosphate. In order to investigate the mechanism of action of MA1831, we determined its crystal structures in apo-form and in complex with substrates and analogues. The complex structures that contain isopentenyl S-thiolodiphosphate and DMAPP as homoallylic substrates were also reported, which should represent the reaction modes of MA1831-mediated head-to-tail and head-to-middle reaction, respectively. Based on the structural information, the mechanism of MA1831 catalyze head-to-tail and head-to-middle condensation reaction was proposed.
		+
		+	Structural insights to a bi-functional isoprenyl diphosphate synthase that can catalyze head-to-tail and head-to-middle condensation.,Zhang L, Zhang X, Min J, Liu B, Huang JW, Yang Y, Liu W, Dai L, Yang Y, Chen CC, Guo RT Int J Biol Macromol. 2022 Aug 1;214:492-499. doi: 10.1016/j.ijbiomac.2022.06.146., Epub 2022 Jun 25. PMID:35764165<ref>PMID:35764165</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7vqa" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Methanosarcina acetivorans C2A]]
	[[Category: Chen CC]]		[[Category: Chen CC]]
	[[Category: Guo RT]]		[[Category: Guo RT]]

OCA at 06:38, 31 August 2022

2022-08-31T06:38:01Z

←Older revision		Revision as of 06:38, 31 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7vqa is ~~ON HOLD until Paper Publication~~	+	==Structure of MA1831 from Methanosarcina acetivorans in complex with dimethylallyl diphosphate.==
-		+	<StructureSection load='7vqa' size='340' side='right'caption='[[7vqa]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VQA FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vqa OCA], [https://pdbe.org/7vqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vqa RCSB], [https://www.ebi.ac.uk/pdbsum/7vqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vqa ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen CC]]
		+	[[Category: Guo RT]]
		+	[[Category: Huang JW]]
		+	[[Category: Liu BB]]
		+	[[Category: Liu WD]]
		+	[[Category: Zhang LL]]
		+	[[Category: Zhang XW]]

OCA at 12:18, 17 November 2021

2021-11-17T12:18:34Z

←Older revision		Revision as of 12:18, 17 November 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vqa is ON HOLD	+	The entry 7vqa is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7vqa" [edit=sysop:move=sysop]

2021-10-27T12:52:27Z

Protected "7vqa" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:52, 27 October 2021

OCA: New page: '''Unreleased structure''' The entry 7vqa is ON HOLD Authors: Description: Category: Unreleased Structures

2021-10-27T12:52:25Z

New page: '''Unreleased structure''' The entry 7vqa is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7vqa is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]