7vvv - Revision history

OCA at 19:43, 29 May 2024

2024-05-29T19:43:32Z

←Older revision		Revision as of 19:43, 29 May 2024
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	==Crystal structure of MmtN==		==Crystal structure of MmtN==
-	<StructureSection load='7vvv' size='340' side='right'caption='[[7vvv]]' scene=''>	+	<StructureSection load='7vvv' size='340' side='right'caption='[[7vvv]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VVV FirstGlance]. <br>		<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VVV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vvv OCA], [https://pdbe.org/7vvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vvv RCSB], [https://www.ebi.ac.uk/pdbsum/7vvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vvv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vvv OCA], [https://pdbe.org/7vvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vvv RCSB], [https://www.ebi.ac.uk/pdbsum/7vvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vvv ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[SAM-dependent methyltrasferase 3D structures\|SAM-dependent methyltrasferase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:12, 31 August 2022

2022-08-31T11:12:48Z

←Older revision		Revision as of 11:12, 31 August 2022
Line 1:		Line 1:

	==Crystal structure of MmtN==		==Crystal structure of MmtN==
-	<StructureSection load='7vvv' size='340' side='right'caption='[[7vvv]]~~, [[Resolution\|resolution]] 2.45Å~~' scene=''>	+	<StructureSection load='7vvv' size='340' side='right'caption='[[7vvv]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[7vvv]] is a 3 chain structure.~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VVV FirstGlance]. <br>
-	</td></tr>~~<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vvv OCA], [https://pdbe.org/7vvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vvv RCSB], [https://www.ebi.ac.uk/pdbsum/7vvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vvv ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vvv OCA], [https://pdbe.org/7vvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vvv RCSB], [https://www.ebi.ac.uk/pdbsum/7vvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vvv ProSAT]</span></td></tr>	+
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Dimethylsulfoniopropionate (DMSP) is an important marine anti-stress compound, with key roles in global nutrient cycling, chemotaxis and, potentially, climate regulation. Recently, diverse marine Actinobacteria, alpha- and gamma-proteobacteria were shown to initiate DMSP synthesis via the methionine (Met) S-methyltransferase enzyme (MmtN), generating S-methyl-Met (SMM). Here we characterize a roseobacterial MmtN, providing structural and mechanistic insights into this DMSP synthesis enzyme. We propose that MmtN uses the proximity and desolvation mechanism for Met S-methylation with two adjacent MmtN monomers comprising the Met binding site. We also identify diverse functional MmtN enzymes in potentially symbiotic archaeal Candidatus Woesearchaeota and Candidate Phyla Radiation (CPR) bacteria, and the animalcule Adineta steineri, not anticipated to produce SMM and/or DMSP. These diverse MmtN enzymes, alongside the larger plant MMT enzyme with an N-terminus homologous to MmtN, likely utilize the same proximity and desolvation mechanism. This study provides important insights into the catalytic mechanism of SMM and/or DMSP production, and proposes roles for these compounds in secondary metabolite production, and SMM cycling in diverse organisms and environments.
-
-	Insights into methionine S-methylation in diverse organisms.,Peng M, Li CY, Chen XL, Williams BT, Li K, Gao YN, Wang P, Wang N, Gao C, Zhang S, Schoelmerich MC, Banfield JF, Miller JB, Le Brun NE, Todd JD, Zhang YZ Nat Commun. 2022 May 26;13(1):2947. doi: 10.1038/s41467-022-30491-5. PMID:35618717<ref>PMID:35618717</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 7vvv" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li~~, C Y~~]]	+	[[Category: Li CY]]
-	[[Category: Peng, M]]	+	[[Category: Peng M]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Rossmann-like]]~~	+
-	~~[[Category: Sam dependent]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Trimer~~]]	+

OCA at 05:16, 25 August 2022

2022-08-25T05:16:05Z

←Older revision		Revision as of 05:16, 25 August 2022
Line 1:		Line 1:

	==Crystal structure of MmtN==		==Crystal structure of MmtN==
-	<StructureSection load='7vvv' size='340' side='right'caption='[[7vvv]]' scene=''>	+	<StructureSection load='7vvv' size='340' side='right'caption='[[7vvv]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vvv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VVV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vvv OCA], [https://pdbe.org/7vvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vvv RCSB], [https://www.ebi.ac.uk/pdbsum/7vvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vvv ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vvv OCA], [https://pdbe.org/7vvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vvv RCSB], [https://www.ebi.ac.uk/pdbsum/7vvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vvv ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dimethylsulfoniopropionate (DMSP) is an important marine anti-stress compound, with key roles in global nutrient cycling, chemotaxis and, potentially, climate regulation. Recently, diverse marine Actinobacteria, alpha- and gamma-proteobacteria were shown to initiate DMSP synthesis via the methionine (Met) S-methyltransferase enzyme (MmtN), generating S-methyl-Met (SMM). Here we characterize a roseobacterial MmtN, providing structural and mechanistic insights into this DMSP synthesis enzyme. We propose that MmtN uses the proximity and desolvation mechanism for Met S-methylation with two adjacent MmtN monomers comprising the Met binding site. We also identify diverse functional MmtN enzymes in potentially symbiotic archaeal Candidatus Woesearchaeota and Candidate Phyla Radiation (CPR) bacteria, and the animalcule Adineta steineri, not anticipated to produce SMM and/or DMSP. These diverse MmtN enzymes, alongside the larger plant MMT enzyme with an N-terminus homologous to MmtN, likely utilize the same proximity and desolvation mechanism. This study provides important insights into the catalytic mechanism of SMM and/or DMSP production, and proposes roles for these compounds in secondary metabolite production, and SMM cycling in diverse organisms and environments.
		+
		+	Insights into methionine S-methylation in diverse organisms.,Peng M, Li CY, Chen XL, Williams BT, Li K, Gao YN, Wang P, Wang N, Gao C, Zhang S, Schoelmerich MC, Banfield JF, Miller JB, Le Brun NE, Todd JD, Zhang YZ Nat Commun. 2022 May 26;13(1):2947. doi: 10.1038/s41467-022-30491-5. PMID:35618717<ref>PMID:35618717</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7vvv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li CY]]	+	[[Category: Li, C Y]]
-	[[Category: Peng M]]	+	[[Category: Peng, M]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Rossmann-like]]
		+	[[Category: Sam dependent]]
		+	[[Category: Transferase]]
		+	[[Category: Trimer]]

OCA at 02:58, 21 April 2022

2022-04-21T02:58:01Z

←Older revision		Revision as of 02:58, 21 April 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7vvv ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of MmtN==
-		+	<StructureSection load='7vvv' size='340' side='right'caption='[[7vvv]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VVV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vvv OCA], [https://pdbe.org/7vvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vvv RCSB], [https://www.ebi.ac.uk/pdbsum/7vvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vvv ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li CY]]
		+	[[Category: Peng M]]

OCA at 15:46, 15 December 2021

2021-12-15T15:46:44Z

←Older revision		Revision as of 15:46, 15 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vvv is ON HOLD	+	The entry 7vvv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7vvv" [edit=sysop:move=sysop]

2021-11-17T12:20:47Z

Protected "7vvv" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:20, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7vvv is ON HOLD Authors: Description: Category: Unreleased Structures

2021-11-17T12:20:45Z

New page: '''Unreleased structure''' The entry 7vvv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7vvv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]