7vwa - Revision history

OCA at 17:33, 29 November 2023

2023-11-29T17:33:31Z

←Older revision		Revision as of 17:33, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7vwa' size='340' side='right'caption='[[7vwa]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='7vwa' size='340' side='right'caption='[[7vwa]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7vwa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vwa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicoverpa_armigera Helicoverpa armigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VWA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=81K:(Z)~~-~~hexadec-9-enal'>81K</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[7vw9\|7vw9]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=81K:(Z)-hexadec-9-enal'>81K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vwa OCA], [https://pdbe.org/7vwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vwa RCSB], [https://www.ebi.ac.uk/pdbsum/7vwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vwa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vwa OCA], [https://pdbe.org/7vwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vwa RCSB], [https://www.ebi.ac.uk/pdbsum/7vwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vwa ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F5ANH9_HELAM F5ANH9_HELAM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7vwa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7vwa" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pheromone binding protein\|Pheromone binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Large Structures]]
-	[[Category: Chen, Z]]
-	[[Category: Zheng, J]]
	[[Category: Helicoverpa armigera]]		[[Category: Helicoverpa armigera]]
-	[[Category: ~~Ligand binding mechanism~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pheromone binding protein~~]]	+	[[Category: Chen Z]]
-	[[Category: ~~Transport protein~~]]	+	[[Category: Zheng J]]

OCA at 07:33, 2 March 2022

2022-03-02T07:33:35Z

←Older revision		Revision as of 07:33, 2 March 2022
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	==Helicoverpa armigera pheromone-binding protein PBP1 with Z-9-hexadecenal==		==Helicoverpa armigera pheromone-binding protein PBP1 with Z-9-hexadecenal==
-	<StructureSection load='7vwa' size='340' side='right'caption='[[7vwa]]' scene=''>	+	<StructureSection load='7vwa' size='340' side='right'caption='[[7vwa]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vwa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VWA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vwa OCA], [https://pdbe.org/7vwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vwa RCSB], [https://www.ebi.ac.uk/pdbsum/7vwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vwa ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=81K:(Z)-hexadec-9-enal'>81K</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7vw9\|7vw9]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vwa OCA], [https://pdbe.org/7vwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vwa RCSB], [https://www.ebi.ac.uk/pdbsum/7vwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vwa ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cotton bollworm (Helicoverpa armigera) is a worldwide agricultural pest in which the transport of pheromones is indispensable and perceived by pheromone-binding proteins (PBPs). However, three-dimensional structure, pheromone binding, and releasing mechanisms of PBPs are not completely illustrated. Here, we solved three structures of the cotton bollworm HarmPBP1 at different pH values and its complex with ligand, Z-9-hexadecenal. Although apo-HarmPBP1 adopts a common PBP scaffold of six alpha-helices surrounding a predominantly hydrophobic central pocket, the conformation is greatly distinct from other apo-PBPs. The Z-9-hexadecenal is bound mainly by hydrophobic interaction. The pheromone can enter this cavity through an opening between the helices alpha5 and alpha6, as well as the loop between alpha3 and alpha4. Structural analysis suggests that ligand entry into the pocket is followed by a shift of Lys94 and Lys138, which may act as a lid at the opening of the pocket. Acidic pH will cause a subtle structural change of the lid, which in turn affects its ligand-binding ability, differently from other family proteins. Taken together, this study provides structural bases for the interactions between pheromones and PBPs, the pH-induced conformational switch, and the design of small inhibitors to control cotton bollworms by disrupting male-female chemosensory communication.
		+
		+	Structural Insights into the Ligand-Binding and -Releasing Mechanism of Helicoverpa armigera Pheromone-Binding Protein PBP1.,Zheng J, Yang M, Dong K, Zhang J, Wang H, Xie M, Wu W, Zhang YJ, Chen Z Int J Mol Sci. 2022 Jan 21;23(3). pii: ijms23031190. doi: 10.3390/ijms23031190. PMID:35163109<ref>PMID:35163109</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7vwa" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen Z]]	+	[[Category: Chen, Z]]
-	[[Category: Zheng J]]	+	[[Category: Zheng, J]]
		+	[[Category: Helicoverpa armigera]]
		+	[[Category: Ligand binding mechanism]]
		+	[[Category: Pheromone binding protein]]
		+	[[Category: Transport protein]]

OCA at 07:04, 2 February 2022

2022-02-02T07:04:50Z

←Older revision		Revision as of 07:04, 2 February 2022
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-	'''Unreleased structure'''

-	~~The entry 7vwa is ON HOLD until Paper Publication~~	+	==Helicoverpa armigera pheromone-binding protein PBP1 with Z-9-hexadecenal==
-		+	<StructureSection load='7vwa' size='340' side='right'caption='[[7vwa]]' scene=''>
-	~~Authors: Zheng, J., Chen, Z.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VWA FirstGlance]. <br>
-	~~Description:~~ Helicoverpa armigera pheromone-binding protein PBP1 with Z-9-hexadecenal	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vwa OCA], [https://pdbe.org/7vwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vwa RCSB], [https://www.ebi.ac.uk/pdbsum/7vwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vwa ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Chen, Z]]	+	__TOC__
-	[[Category: Zheng, J]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen Z]]
		+	[[Category: Zheng J]]

OCA: Protected "7vwa" [edit=sysop:move=sysop]

2021-11-17T12:21:32Z

Protected "7vwa" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:21, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7vwa is ON HOLD until Paper Publication Authors: Zheng, J., Chen, Z. Description: Helicoverpa armigera pheromone-binding protein PBP1 with Z-9-hexa...

2021-11-17T12:21:30Z

New page: '''Unreleased structure''' The entry 7vwa is ON HOLD until Paper Publication Authors: Zheng, J., Chen, Z. Description: Helicoverpa armigera pheromone-binding protein PBP1 with Z-9-hexa...

New page

'''Unreleased structure'''

The entry 7vwa is ON HOLD until Paper Publication

Authors: Zheng, J., Chen, Z.

Description: Helicoverpa armigera pheromone-binding protein PBP1 with Z-9-hexadecenal
[[Category: Unreleased Structures]]
[[Category: Chen, Z]]
[[Category: Zheng, J]]