7w0t - Revision history

OCA at 17:34, 29 November 2023

2023-11-29T17:34:41Z

←Older revision		Revision as of 17:34, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7w0t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus Coxsackievirus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W0T FirstGlance]. <br>		<table><tr><td colspan='2'>[[7w0t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus Coxsackievirus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W0T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0t OCA], [https://pdbe.org/7w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0t RCSB], [https://www.ebi.ac.uk/pdbsum/7w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0t ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.57Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0t OCA], [https://pdbe.org/7w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0t RCSB], [https://www.ebi.ac.uk/pdbsum/7w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:27, 26 October 2022

2022-10-26T06:27:35Z

←Older revision		Revision as of 06:27, 26 October 2022
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-	====	+	==TRIM7 in complex with C-terminal peptide of 2C==
-	<StructureSection load='7w0t' size='340' side='right'caption='[[7w0t]]' scene=''>	+	<StructureSection load='7w0t' size='340' side='right'caption='[[7w0t]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7w0t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus Coxsackievirus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W0T FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0t OCA], [https://pdbe.org/7w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0t RCSB], [https://www.ebi.ac.uk/pdbsum/7w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0t ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0t OCA], [https://pdbe.org/7w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0t RCSB], [https://www.ebi.ac.uk/pdbsum/7w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0t ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRIM7_HUMAN TRIM7_HUMAN] E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128).[UniProtKB:Q923T7]<ref>PMID:25851810</ref> <ref>PMID:32126128</ref> (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination.<ref>PMID:32641828</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The E3 ligase TRIM7 has emerged as a critical player in viral infection and pathogenesis. However, the mechanism governing the TRIM7-substrate association remains to be defined. Here we report the crystal structures of TRIM7 in complex with 2C peptides of human enterovirus. Structure-guided studies reveal the C-terminal glutamine residue of 2C as the primary determinant for TRIM7 binding. Leveraged by this finding, we identify norovirus and SARS-CoV-2 proteins, and physiological proteins, as new TRIM7 substrates. Crystal structures of TRIM7 in complex with multiple peptides derived from SARS-CoV-2 proteins display the same glutamine-end recognition mode. Furthermore, TRIM7 could trigger the ubiquitination and degradation of these substrates, possibly representing a new Gln/C-degron pathway. Together, these findings unveil a common recognition mode by TRIM7, providing the foundation for further mechanistic characterization of antiviral and cellular functions of TRIM7.
		+
		+	A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.,Liang X, Xiao J, Li X, Liu Y, Lu Y, Wen Y, Li Z, Che X, Ma Y, Zhang X, Zhang Y, Jian D, Wang P, Xuan C, Yu G, Li L, Zhang H Nat Chem Biol. 2022 Aug 18. pii: 10.1038/s41589-022-01128-x. doi:, 10.1038/s41589-022-01128-x. PMID:35982226<ref>PMID:35982226</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7w0t" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Coxsackievirus]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Li XZ]]
		+	[[Category: Liang X]]
		+	[[Category: Zhang H]]

OCA at 05:01, 10 August 2022

2022-08-10T05:01:43Z

←Older revision		Revision as of 05:01, 10 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7w0t ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7w0t' size='340' side='right'caption='[[7w0t]]' scene=''>
-	~~Authors~~: ~~Zhang, H~~.~~, Liang, X~~.~~, Li, X~~.Z.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: a complex of~~ a ~~protein with a peptide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0t OCA], [https://pdbe.org/7w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0t RCSB], [https://www.ebi.ac.uk/pdbsum/7w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0t ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Zhang~~, H]]	+	__TOC__
-	[[Category: ~~Liang, X~~]]	+	</StructureSection>
-	[[Category: ~~Li, X.~~Z]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 15:47, 15 December 2021

2021-12-15T15:47:27Z

←Older revision		Revision as of 15:47, 15 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7w0t is ON HOLD	+	The entry 7w0t is ON HOLD until Paper Publication

	Authors: Zhang, H., Liang, X., Li, X.Z.		Authors: Zhang, H., Liang, X., Li, X.Z.

OCA at 05:18, 1 December 2021

2021-12-01T05:18:17Z

←Older revision		Revision as of 05:18, 1 December 2021
Line 3:		Line 3:
	The entry 7w0t is ON HOLD		The entry 7w0t is ON HOLD

-	Authors: ~~Heng~~, Z., ~~Xiao~~, L., ~~Xuzichao~~, L.	+	Authors: Zhang, H., Liang, X., Li, X.Z.

	Description: a complex of a protein with a peptide		Description: a complex of a protein with a peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Xiao~~, L]]	+	[[Category: Zhang, H]]
-	[[Category: ~~Xuzichao~~, L]]	+	[[Category: Liang, X]]
-	[[Category: ~~Heng~~, Z]]	+	[[Category: Li, X.Z]]

OCA: Protected "7w0t" [edit=sysop:move=sysop]

2021-11-24T11:11:59Z

Protected "7w0t" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:11, 24 November 2021

OCA: New page: '''Unreleased structure''' The entry 7w0t is ON HOLD Authors: Heng, Z., Xiao, L., Xuzichao, L. Description: a complex of a protein with a peptide Category: Unreleased Structures [[...

2021-11-24T11:11:58Z

New page: '''Unreleased structure''' The entry 7w0t is ON HOLD Authors: Heng, Z., Xiao, L., Xuzichao, L. Description: a complex of a protein with a peptide Category: Unreleased Structures [[...

New page

'''Unreleased structure'''

The entry 7w0t is ON HOLD

Authors: Heng, Z., Xiao, L., Xuzichao, L.

Description: a complex of a protein with a peptide
[[Category: Unreleased Structures]]
[[Category: Xiao, L]]
[[Category: Xuzichao, L]]
[[Category: Heng, Z]]