OCA at 03:22, 8 September 2022

2022-09-08T03:22:49Z

←Older revision		Revision as of 03:22, 8 September 2022
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	==sodium channel IV==		==sodium channel IV==
-	<StructureSection load='7wfw' size='340' side='right'caption='[[7wfw]]' scene=''>	+	<StructureSection load='7wfw' size='340' side='right'caption='[[7wfw]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WFW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7wfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WFW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wfw OCA], [https://pdbe.org/7wfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wfw RCSB], [https://www.ebi.ac.uk/pdbsum/7wfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wfw ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=LPE:1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>LPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wfw OCA], [https://pdbe.org/7wfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wfw RCSB], [https://www.ebi.ac.uk/pdbsum/7wfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wfw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/SCNAA_HUMAN SCNAA_HUMAN]] Congenital insensitivity to pain-anosmia-neuropathic arthropathy;Primary erythromelalgia;Sodium channelopathy-related small fiber neuropathy;Brugada syndrome;Paroxysmal extreme pain disorder;Romano-Ward syndrome. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SCNAA_HUMAN SCNAA_HUMAN]] Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.<ref>PMID:9839820</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The dorsal root ganglia-localized voltage-gated sodium (Nav) channel Nav1.8 represents a promising target for developing next-generation analgesics. A prominent characteristic of Nav1.8 is the requirement of more depolarized membrane potential for activation. Here we present the cryogenic electron microscopy structures of human Nav1.8 alone and bound to a selective pore blocker, A-803467, at overall resolutions of 2.7 to 3.2 A. The first voltage-sensing domain (VSDI) displays three different conformations. Structure-guided mutagenesis identified the extracellular interface between VSDI and the pore domain (PD) to be a determinant for the high-voltage dependence of activation. A-803467 was clearly resolved in the central cavity of the PD, clenching S6IV. Our structure-guided functional characterizations show that two nonligand binding residues, Thr397 on S6I and Gly1406 on S6III, allosterically modulate the channel's sensitivity to A-803467. Comparison of available structures of human Nav channels suggests the extracellular loop region to be a potential site for developing subtype-specific pore-blocking biologics.
		+
		+	Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8.,Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2208211119. doi:, 10.1073/pnas.2208211119. Epub 2022 Jul 19. PMID:35858452<ref>PMID:35858452</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7wfw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Huang GX]]		[[Category: Huang GX]]

OCA at 04:54, 3 August 2022

2022-08-03T04:54:48Z

←Older revision		Revision as of 04:54, 3 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7wfw is ~~ON HOLD until Paper Publication~~	+	==sodium channel IV==
-		+	<StructureSection load='7wfw' size='340' side='right'caption='[[7wfw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WFW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wfw OCA], [https://pdbe.org/7wfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wfw RCSB], [https://www.ebi.ac.uk/pdbsum/7wfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wfw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Huang GX]]
		+	[[Category: Huang XS]]
		+	[[Category: Pan XJ]]
		+	[[Category: Yan N]]

OCA at 09:15, 16 February 2022

2022-02-16T09:15:22Z

←Older revision		Revision as of 09:15, 16 February 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7wfw is ON HOLD	+	The entry 7wfw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7wfw" [edit=sysop:move=sysop]

2022-01-05T09:27:01Z

Protected "7wfw" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:27, 5 January 2022

OCA: New page: '''Unreleased structure''' The entry 7wfw is ON HOLD Authors: Description: Category: Unreleased Structures

2022-01-05T09:26:59Z

New page: '''Unreleased structure''' The entry 7wfw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7wfw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7wfw - Revision history

OCA at 03:22, 8 September 2022

OCA at 04:54, 3 August 2022

OCA at 09:15, 16 February 2022

OCA: Protected "7wfw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7wfw is ON HOLD Authors: Description: Category: Unreleased Structures