7x70 - Revision history

OCA at 17:48, 29 November 2023

2023-11-29T17:48:43Z

←Older revision		Revision as of 17:48, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7x70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X70 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7x70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X70 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x70 OCA], [https://pdbe.org/7x70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x70 RCSB], [https://www.ebi.ac.uk/pdbsum/7x70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x70 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x70 OCA], [https://pdbe.org/7x70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x70 RCSB], [https://www.ebi.ac.uk/pdbsum/7x70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x70 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:28, 26 October 2022

2022-10-26T06:28:16Z

←Older revision		Revision as of 06:28, 26 October 2022
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-	====	+	==TRIM7 in complex with C-terminal peptide of NSP8==
-	<StructureSection load='7x70' size='340' side='right'caption='[[7x70]]' scene=''>	+	<StructureSection load='7x70' size='340' side='right'caption='[[7x70]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7x70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X70 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x70 OCA], [https://pdbe.org/7x70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x70 RCSB], [https://www.ebi.ac.uk/pdbsum/7x70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x70 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x70 OCA], [https://pdbe.org/7x70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x70 RCSB], [https://www.ebi.ac.uk/pdbsum/7x70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x70 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRIM7_HUMAN TRIM7_HUMAN] E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128).[UniProtKB:Q923T7]<ref>PMID:25851810</ref> <ref>PMID:32126128</ref> (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination.<ref>PMID:32641828</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The E3 ligase TRIM7 has emerged as a critical player in viral infection and pathogenesis. However, the mechanism governing the TRIM7-substrate association remains to be defined. Here we report the crystal structures of TRIM7 in complex with 2C peptides of human enterovirus. Structure-guided studies reveal the C-terminal glutamine residue of 2C as the primary determinant for TRIM7 binding. Leveraged by this finding, we identify norovirus and SARS-CoV-2 proteins, and physiological proteins, as new TRIM7 substrates. Crystal structures of TRIM7 in complex with multiple peptides derived from SARS-CoV-2 proteins display the same glutamine-end recognition mode. Furthermore, TRIM7 could trigger the ubiquitination and degradation of these substrates, possibly representing a new Gln/C-degron pathway. Together, these findings unveil a common recognition mode by TRIM7, providing the foundation for further mechanistic characterization of antiviral and cellular functions of TRIM7.
		+
		+	A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.,Liang X, Xiao J, Li X, Liu Y, Lu Y, Wen Y, Li Z, Che X, Ma Y, Zhang X, Zhang Y, Jian D, Wang P, Xuan C, Yu G, Li L, Zhang H Nat Chem Biol. 2022 Aug 18. pii: 10.1038/s41589-022-01128-x. doi:, 10.1038/s41589-022-01128-x. PMID:35982226<ref>PMID:35982226</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7x70" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Li XZ]]
		+	[[Category: Liang X]]
		+	[[Category: Zhang H]]

OCA at 05:02, 10 August 2022

2022-08-10T05:02:25Z

←Older revision		Revision as of 05:02, 10 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7x70 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7x70' size='340' side='right'caption='[[7x70]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x70 OCA], [https://pdbe.org/7x70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x70 RCSB], [https://www.ebi.ac.uk/pdbsum/7x70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x70 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 08:40, 13 April 2022

2022-04-13T08:40:11Z

←Older revision		Revision as of 08:40, 13 April 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7x70 is ON HOLD	+	The entry 7x70 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7x70" [edit=sysop:move=sysop]

2022-03-16T05:13:23Z

Protected "7x70" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:13, 16 March 2022

OCA: New page: '''Unreleased structure''' The entry 7x70 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-03-16T05:13:22Z

New page: '''Unreleased structure''' The entry 7x70 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7x70 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]