7x9s - Revision history

OCA at 17:49, 29 November 2023

2023-11-29T17:49:54Z

←Older revision		Revision as of 17:49, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7x9s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X9S FirstGlance]. <br>		<table><tr><td colspan='2'>[[7x9s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X9S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x9s OCA], [https://pdbe.org/7x9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x9s RCSB], [https://www.ebi.ac.uk/pdbsum/7x9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x9s ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.11Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x9s OCA], [https://pdbe.org/7x9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x9s RCSB], [https://www.ebi.ac.uk/pdbsum/7x9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x9s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:09, 24 November 2022

2022-11-24T10:09:06Z

←Older revision		Revision as of 10:09, 24 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7x9s is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of a complex between the antirepressor GmaR and the transcriptional repressor MogR==
		+	<StructureSection load='7x9s' size='340' side='right'caption='[[7x9s]], [[Resolution\|resolution]] 3.11Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7x9s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X9S FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x9s OCA], [https://pdbe.org/7x9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x9s RCSB], [https://www.ebi.ac.uk/pdbsum/7x9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x9s ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A3A6YDN3_LISMN A0A3A6YDN3_LISMN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The pathogenic Listeria monocytogenes bacterium produces the flagellum as a locomotive organelle at or below 30 degrees C outside the host, but it halts flagellar expression at 37 degrees C inside the human host to evade the flagellum-induced immune response. Listeria monocytogenes GmaR is a thermosensor protein that coordinates flagellar expression by binding the master transcriptional repressor of flagellar genes (MogR) in a temperature-responsive manner. To understand the regulatory mechanism whereby GmaR exerts the antirepression activity on flagellar expression, we performed structural and mutational analyses of the GmaR-MogR system. At or below 30 degrees C, GmaR exists as a functional monomer and forms a circularly enclosed multidomain structure via an interdomain interaction. GmaR in this conformation recognizes MogR using the C-terminal antirepressor domain in a unique dual binding mode and mediates the antirepressor function through direct competition and spatial restraint mechanisms. Surprisingly, at 37 degrees C, GmaR rapidly forms autologous aggregates that are deficient in MogR neutralization capabilities.

-	~~Authors~~:	+	Structural basis of flagellar motility regulation by the MogR repressor and the GmaR antirepressor in Listeria monocytogenes.,Cho SY, Na HW, Oh HB, Kwak YM, Song WS, Park SC, Jeon WJ, Cho H, Oh BC, Park J, Kang SG, Lee GS, Yoon SI Nucleic Acids Res. 2022 Oct 28;50(19):11315-11330. doi: 10.1093/nar/gkac815. PMID:36283692<ref>PMID:36283692</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7x9s" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Listeria monocytogenes]]
		+	[[Category: Cho SY]]
		+	[[Category: Kwak YM]]
		+	[[Category: Na HW]]
		+	[[Category: Oh HB]]
		+	[[Category: Park SC]]
		+	[[Category: Song WS]]
		+	[[Category: Yoon SI]]

OCA at 09:41, 30 March 2022

2022-03-30T09:41:54Z

←Older revision		Revision as of 09:41, 30 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7x9s is ON HOLD	+	The entry 7x9s is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7x9s" [edit=sysop:move=sysop]

2022-03-23T10:02:50Z

Protected "7x9s" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:02, 23 March 2022

OCA: New page: '''Unreleased structure''' The entry 7x9s is ON HOLD Authors: Description: Category: Unreleased Structures

2022-03-23T10:02:49Z

New page: '''Unreleased structure''' The entry 7x9s is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7x9s is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]