http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=7yds 7yds - Revision history 2026-04-13T08:47:25Z Revision history for this page on the wiki MediaWiki 1.11.2 http://52.214.119.220/wiki/index.php?title=7yds&diff=3806511&oldid=prev OCA at 06:09, 19 July 2023 2023-07-19T06:09:07Z <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 06:09, 19 July 2023</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The <del style="color: red; font-weight: bold; text-decoration: none;">entry </del>7yds <del style="color: red; font-weight: bold; text-decoration: none;">is ON HOLD until Paper Publication</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==</ins>The <ins style="color: red; font-weight: bold; text-decoration: none;">structure of the bispecific antibody targeted PD-L1 and 4-1BB==</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>&#160;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;StructureSection load='</ins>7yds<ins style="color: red; font-weight: bold; text-decoration: none;">' size='340' side='right'caption='[[7yds]], [[Resolution|resolution]] 2.30&amp;Aring;' scene=''&gt;</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Authors</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Gao, Y</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Zhu, M</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Liu, W</del>.<del style="color: red; font-weight: bold; text-decoration: none;">T</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Cheng</del>, <del style="color: red; font-weight: bold; text-decoration: none;">L</del>.<del style="color: red; font-weight: bold; text-decoration: none;">S</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Zhu, Z</del>.<del style="color: red; font-weight: bold; text-decoration: none;">L</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Niu, L</del>.<del style="color: red; font-weight: bold; text-decoration: none;">W</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>&#160;</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;table&gt;&lt;tr&gt;&lt;td colspan='2'&gt;[[7yds]] is a 3 chain structure with sequence from [https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//en</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YDS OCA]. For a &lt;b&gt;guided tour on the structure components&lt;/b&gt; use [https://proteopedia.org/fgij/fg.htm?mol=7YDS FirstGlance]. &lt;br&gt;</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Description</del>: <del style="color: red; font-weight: bold; text-decoration: none;">The structure of </del>the <del style="color: red; font-weight: bold; text-decoration: none;">bispecific antibody targeted PD</del>-<del style="color: red; font-weight: bold; text-decoration: none;">L1 </del>and <del style="color: red; font-weight: bold; text-decoration: none;">4</del>-<del style="color: red; font-weight: bold; text-decoration: none;">1BB</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;/td&gt;&lt;/tr&gt;&lt;tr id='method'&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;[[Empirical_models|Method:]]&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot; id=&quot;methodDat&quot;&gt;X-ray diffraction</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[[Resolution|Resolution]] 2</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">3&amp;#8491;&lt;/td&gt;&lt;/tr&gt;</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Unreleased Structures</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;tr id='resources'&gt;&lt;td class=&quot;sblockLbl&quot;&gt;&lt;b&gt;Resources:&lt;/b&gt;&lt;/td&gt;&lt;td class=&quot;sblockDat&quot;&gt;&lt;span class='plainlinks'&gt;[https://proteopedia.org/fgij/fg.htm?mol=7yds FirstGlance]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac.il/oca-bin/ocaids?id=7yds OCA]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://pdbe.org/7yds PDBe]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">rcsb</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/pdb/explore.do?structureId=7yds RCSB]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ebi</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac.uk/pdbsum/7yds PDBsum]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://prosat</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">h-its</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/prosat/prosatexe?pdbcode=7yds ProSAT]&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Gao, Y</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;/table&gt;</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Zhu, Z.L</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Function ==</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Niu, L.W</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in </ins>the <ins style="color: red; font-weight: bold; text-decoration: none;">costimulatory signal, essential for T</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">cell proliferation </ins>and <ins style="color: red; font-weight: bold; text-decoration: none;">production of IL10 and IFNG, in an IL2</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.&lt;ref&gt;PMID:10581077&lt;/ref&gt; &lt;ref&gt;PMID:11015443&lt;/ref&gt; </ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Liu<del style="color: red; font-weight: bold; text-decoration: none;">, W.T</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Zhu<del style="color: red; font-weight: bold; text-decoration: none;">, </del>M]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;references/&gt;</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Cheng, L.S</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;/StructureSection&gt;</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Homo sapiens</ins>]]</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Large Structures</ins>]]</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Cheng LS</ins>]]</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Gao Y</ins>]]</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Liu <ins style="color: red; font-weight: bold; text-decoration: none;">WT]]</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Niu LW</ins>]]</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Zhu M]]</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Zhu ZL</ins>]]</div></td></tr> </table> OCA http://52.214.119.220/wiki/index.php?title=7yds&diff=3603361&oldid=prev OCA at 03:29, 18 August 2022 2022-08-18T03:29:08Z <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 03:29, 18 August 2022</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The entry 7yds is ON HOLD </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The entry 7yds is ON HOLD <ins style="color: red; font-weight: bold; text-decoration: none;"> until Paper Publication</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Gao, Y., Zhu, M., Liu, W.T., Cheng, L.S., Zhu, Z.L., Niu, L.W.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Gao, Y., Zhu, M., Liu, W.T., Cheng, L.S., Zhu, Z.L., Niu, L.W.</div></td></tr> <tr><td colspan="2" class="diff-lineno">Line 9:</td> <td colspan="2" class="diff-lineno">Line 9:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Gao, Y]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Gao, Y]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Zhu, Z.L]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Zhu, Z.L]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Zhu, M]]</div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Niu, L.W]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Niu, L.W]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Cheng, L.S]]</div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Liu, W.T]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Liu, W.T]]</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Zhu, M]]</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Cheng, L.S]]</div></td></tr> </table> OCA http://52.214.119.220/wiki/index.php?title=7yds&diff=3588977&oldid=prev OCA: Protected "7yds" [edit=sysop:move=sysop] 2022-07-13T04:01:26Z <p>Protected &quot;<a href="/wiki/index.php/7yds" title="7yds">7yds</a>&quot; [edit=sysop:move=sysop]</p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 04:01, 13 July 2022</td> </tr> </table> OCA http://52.214.119.220/wiki/index.php?title=7yds&diff=3588976&oldid=prev OCA: New page: '''Unreleased structure''' The entry 7yds is ON HOLD Authors: Gao, Y., Zhu, M., Liu, W.T., Cheng, L.S., Zhu, Z.L., Niu, L.W. Description: The structure of the bispecific antibody targe... 2022-07-13T04:01:25Z <p>New page: '''Unreleased structure''' The entry 7yds is ON HOLD Authors: Gao, Y., Zhu, M., Liu, W.T., Cheng, L.S., Zhu, Z.L., Niu, L.W. Description: The structure of the bispecific antibody targe...</p> <p><b>New page</b></p><div>'''Unreleased structure'''<br /> <br /> The entry 7yds is ON HOLD <br /> <br /> Authors: Gao, Y., Zhu, M., Liu, W.T., Cheng, L.S., Zhu, Z.L., Niu, L.W.<br /> <br /> Description: The structure of the bispecific antibody targeted PD-L1 and 4-1BB<br /> [[Category: Unreleased Structures]]<br /> [[Category: Gao, Y]]<br /> [[Category: Zhu, Z.L]]<br /> [[Category: Zhu, M]]<br /> [[Category: Niu, L.W]]<br /> [[Category: Cheng, L.S]]<br /> [[Category: Liu, W.T]]</div> OCA