7zl6 - Revision history

OCA at 16:57, 8 November 2023

2023-11-08T16:57:33Z

←Older revision		Revision as of 16:57, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7zl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7zl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IWE:Azosemide'>IWE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.383Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IWE:Azosemide'>IWE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl6 OCA], [https://pdbe.org/7zl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl6 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl6 OCA], [https://pdbe.org/7zl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl6 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl6 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:01, 26 April 2023

2023-04-26T17:01:21Z

←Older revision		Revision as of 17:01, 26 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7zl6 is ~~ON HOLD until Paper Publication~~	+	==Azosemide in complex with human Carbonic anhydrase II (hCA II)==
-		+	<StructureSection load='7zl6' size='340' side='right'caption='[[7zl6]], [[Resolution\|resolution]] 1.38Å' scene=''>
-	~~Authors~~: ~~Angeli~~, A., ~~Ferraroni~~, M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL6 FirstGlance]. <br>
-	~~Description~~: ~~Azosemide~~ in ~~complex~~ with ~~human Carbonic~~ anhydrase II (~~hCA II~~)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IWE:Azosemide'>IWE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl6 OCA], [https://pdbe.org/7zl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl6 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl6 ProSAT]</span></td></tr>
-	[[Category: Angeli, A]]	+	</table>
-	[[Category: Ferraroni, M]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Angeli A]]
		+	[[Category: Ferraroni M]]

OCA at 07:12, 22 June 2022

2022-06-22T07:12:40Z

←Older revision		Revision as of 07:12, 22 June 2022
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	Description: Azosemide in complex with human Carbonic anhydrase II (hCA II)		Description: Azosemide in complex with human Carbonic anhydrase II (hCA II)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ferraroni, M]]
	[[Category: Angeli, A]]		[[Category: Angeli, A]]
		+	[[Category: Ferraroni, M]]

OCA at 09:16, 18 May 2022

2022-05-18T09:16:01Z

←Older revision		Revision as of 09:16, 18 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zl6 is ON HOLD	+	The entry 7zl6 is ON HOLD until Paper Publication

	Authors: Angeli, A., Ferraroni, M.		Authors: Angeli, A., Ferraroni, M.
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	Description: Azosemide in complex with human Carbonic anhydrase II (hCA II)		Description: Azosemide in complex with human Carbonic anhydrase II (hCA II)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Angeli, A]]
	[[Category: Ferraroni, M]]		[[Category: Ferraroni, M]]
		+	[[Category: Angeli, A]]

OCA: Protected "7zl6" [edit=sysop:move=sysop]

2022-04-21T01:53:21Z

Protected "7zl6" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:53, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7zl6 is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Azosemide in complex with human Carbonic anhydrase II (hCA II) [[Category: Unreleas...

2022-04-21T01:53:20Z

New page: '''Unreleased structure''' The entry 7zl6 is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Azosemide in complex with human Carbonic anhydrase II (hCA II) [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 7zl6 is ON HOLD

Authors: Angeli, A., Ferraroni, M.

Description: Azosemide in complex with human Carbonic anhydrase II (hCA II)
[[Category: Unreleased Structures]]
[[Category: Angeli, A]]
[[Category: Ferraroni, M]]