7zmx - Revision history

OCA at 08:04, 7 February 2024

2024-02-07T08:04:49Z

←Older revision		Revision as of 08:04, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7zmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZMX FirstGlance]. <br>		<table><tr><td colspan='2'>[[7zmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZMX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zmx OCA], [https://pdbe.org/7zmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zmx RCSB], [https://www.ebi.ac.uk/pdbsum/7zmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zmx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zmx OCA], [https://pdbe.org/7zmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zmx RCSB], [https://www.ebi.ac.uk/pdbsum/7zmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zmx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:49, 10 May 2023

2023-05-10T06:49:33Z

←Older revision		Revision as of 06:49, 10 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7zmx is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the Plant Homeodomain (PHD) of human ING3==
-		+	<StructureSection load='7zmx' size='340' side='right'caption='[[7zmx]], [[Resolution\|resolution]] 1.20Å' scene=''>
-	~~Authors~~: ~~Ferreras~~, M.O., ~~Medrano~~, F.J., ~~Blanco~~, F.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZMX FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of the ~~Plant Homeodomain~~ (~~PHD~~) of ~~human ING3~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zmx OCA], [https://pdbe.org/7zmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zmx RCSB], [https://www.ebi.ac.uk/pdbsum/7zmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zmx ProSAT]</span></td></tr>
-	[[Category: ~~Medrano, F.J~~]]	+	</table>
-	[[Category: Blanco~~, F.J~~]]	+	== Disease ==
-	[[Category: Ferreras~~, M.O~~]]	+	[https://www.uniprot.org/uniprot/ING3_HUMAN ING3_HUMAN] Defects in ING3 may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[https://omim.org/entry/275355 275355]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:12080476</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ING3_HUMAN ING3_HUMAN] Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.<ref>PMID:12545155</ref> <ref>PMID:14966270</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Blanco FJ]]
		+	[[Category: Ferreras MO]]
		+	[[Category: Medrano FJ]]

OCA at 09:16, 18 May 2022

2022-05-18T09:16:38Z

←Older revision		Revision as of 09:16, 18 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zmx is ON HOLD	+	The entry 7zmx is ON HOLD until Paper Publication

	Authors: Ferreras, M.O., Medrano, F.J., Blanco, F.J.		Authors: Ferreras, M.O., Medrano, F.J., Blanco, F.J.
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	Description: Crystal structure of the Plant Homeodomain (PHD) of human ING3		Description: Crystal structure of the Plant Homeodomain (PHD) of human ING3
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Blanco, F.J]]
	[[Category: Medrano, F.J]]		[[Category: Medrano, F.J]]
		+	[[Category: Blanco, F.J]]
	[[Category: Ferreras, M.O]]		[[Category: Ferreras, M.O]]

OCA: Protected "7zmx" [edit=sysop:move=sysop]

2022-04-27T10:42:19Z

Protected "7zmx" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:42, 27 April 2022

OCA: New page: '''Unreleased structure''' The entry 7zmx is ON HOLD Authors: Ferreras, M.O., Medrano, F.J., Blanco, F.J. Description: Crystal structure of the Plant Homeodomain (PHD) of human ING3 [[...

2022-04-27T10:42:18Z

New page: '''Unreleased structure''' The entry 7zmx is ON HOLD Authors: Ferreras, M.O., Medrano, F.J., Blanco, F.J. Description: Crystal structure of the Plant Homeodomain (PHD) of human ING3 [[...

New page

'''Unreleased structure'''

The entry 7zmx is ON HOLD

Authors: Ferreras, M.O., Medrano, F.J., Blanco, F.J.

Description: Crystal structure of the Plant Homeodomain (PHD) of human ING3
[[Category: Unreleased Structures]]
[[Category: Blanco, F.J]]
[[Category: Medrano, F.J]]
[[Category: Ferreras, M.O]]