7zzs - Revision history

OCA at 07:36, 3 November 2022

2022-11-03T07:36:13Z

←Older revision		Revision as of 07:36, 3 November 2022
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	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HDAC2_HUMAN HDAC2_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:19343227</ref>	+	[https://www.uniprot.org/uniprot/HDAC2_HUMAN HDAC2_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:19343227</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:46, 21 September 2022

2022-09-21T07:46:31Z

←Older revision		Revision as of 07:46, 21 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7zzs is ~~ON HOLD until Paper Publication~~	+	==HDAC2 complexed with an inhibitory ligand==
-		+	<StructureSection load='7zzs' size='340' side='right'caption='[[7zzs]], [[Resolution\|resolution]] 1.88Å' scene=''>
-	~~Authors~~: ~~Cleasby~~, A., ~~Tisi~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7zzs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZZS FirstGlance]. <br>
-	~~Description~~: ~~HDAC2 complexed with~~ an ~~inhibitory ligand~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KK0:(5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one'>KK0</scene>, <scene name='pdbligand=KZF:2-(cyclohexylazaniumyl)ethanesulfonate'>KZF</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SHH:OCTANEDIOIC+ACID+HYDROXYAMIDE+PHENYLAMIDE'>SHH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zzs OCA], [https://pdbe.org/7zzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zzs RCSB], [https://www.ebi.ac.uk/pdbsum/7zzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zzs ProSAT]</span></td></tr>
-	[[Category: ~~Tisi, D~~]]	+	</table>
-	[[Category: Cleasby, A]]	+	== Function ==
		+	[[https://www.uniprot.org/uniprot/HDAC2_HUMAN HDAC2_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:19343227</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Cleasby A]]
		+	[[Category: Tisi D]]

OCA at 04:09, 20 July 2022

2022-07-20T04:09:56Z

←Older revision		Revision as of 04:09, 20 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7zzs is ON HOLD	+	The entry 7zzs is ON HOLD until Paper Publication

	Authors: Cleasby, A., Tisi, D.		Authors: Cleasby, A., Tisi, D.

OCA: Protected "7zzs" [edit=sysop:move=sysop]

2022-06-08T04:19:55Z

Protected "7zzs" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 7zzs is ON HOLD Authors: Cleasby, A., Tisi, D. Description: HDAC2 complexed with an inhibitory ligand Category: Unreleased Structures [[Categor...

2022-06-08T04:19:54Z

New page: '''Unreleased structure''' The entry 7zzs is ON HOLD Authors: Cleasby, A., Tisi, D. Description: HDAC2 complexed with an inhibitory ligand Category: Unreleased Structures [[Categor...

New page

'''Unreleased structure'''

The entry 7zzs is ON HOLD

Authors: Cleasby, A., Tisi, D.

Description: HDAC2 complexed with an inhibitory ligand
[[Category: Unreleased Structures]]
[[Category: Tisi, D]]
[[Category: Cleasby, A]]