8aat - Revision history

OCA at 07:46, 29 November 2017

2017-11-29T07:46:51Z

←Older revision		Revision as of 07:46, 29 November 2017
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		+
	==X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE==		==X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE==
	<StructureSection load='8aat' size='340' side='right' caption='[[8aat]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='8aat' size='340' side='right' caption='[[8aat]], [[Resolution\|resolution]] 2.30Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aat OCA], [http://pdbe.org/8aat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=8aat RCSB], [http://www.ebi.ac.uk/pdbsum/8aat PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aat OCA], [http://pdbe.org/8aat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=8aat RCSB], [http://www.ebi.ac.uk/pdbsum/8aat PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=8aat ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 8aat" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 8aat" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aspartate Aminotransferase\|Aspartate Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:47, 8 February 2016

2016-02-08T12:47:22Z

←Older revision		Revision as of 12:47, 8 February 2016
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	<StructureSection load='8aat' size='340' side='right' caption='[[8aat]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='8aat' size='340' side='right' caption='[[8aat]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[8aat]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8AAT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[8aat]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8AAT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=8aat RCSB], [http://www.ebi.ac.uk/pdbsum/8aat PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aat OCA], [http://pdbe.org/8aat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=8aat RCSB], [http://www.ebi.ac.uk/pdbsum/8aat PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=8aat ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 8aat" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Aspartate transaminase]]		[[Category: Aspartate transaminase]]
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Jansonius, J N]]		[[Category: Jansonius, J N]]
	[[Category: Mcphalen, C A]]		[[Category: Mcphalen, C A]]
	[[Category: Vincent, M G]]		[[Category: Vincent, M G]]

OCA at 23:25, 24 December 2014

2014-12-24T23:25:03Z

←Older revision		Revision as of 23:25, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=8aat RCSB], [http://www.ebi.ac.uk/pdbsum/8aat PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=8aat RCSB], [http://www.ebi.ac.uk/pdbsum/8aat PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AATM_CHICK AATM_CHICK]] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. May facilitate cellular uptake of long-chain free fatty acids (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:54, 10 December 2014

2014-12-10T16:54:56Z

←Older revision		Revision as of 16:54, 10 December 2014
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-	[[~~Image~~:8aat.~~png\|left~~\|200px]]	+	==X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE==
		+	<StructureSection load='8aat' size='340' side='right' caption='[[8aat]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8aat]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8AAT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=8aat RCSB], [http://www.ebi.ac.uk/pdbsum/8aat PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aa/8aat_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray crystal structures of three forms of the enzyme aspartate aminotransferase (EC 2.6.1.1) from chicken heart mitochondria have been refined by least-squares methods: holoenzyme with the co-factor pyridoxal-5'-phosphate bound at pH 7.5 (1.9 A resolution), holoenzyme with pyridoxal-5'-phosphate bound at pH 5.1 (2.3 A resolution) and holoenzyme with the co-factor pyridoxamine-5'-phosphate bound at pH 7.5 (2.2 A resolution). The crystallographic agreement factors [formula: see text] for the structures are 0.166, 0.130 and 0.131, respectively, for all data in the resolution range from 10.0 A to the limit of diffraction for each structure. The secondary, super-secondary and domain structures of the pyridoxal-phosphate holoenzyme at pH 7.5 are described in detail. The surface area of the interface between the monomer subunits of this dimeric alpha 2 protein is unusually large, indicating a very stable dimer. This is consistent with biochemical data. Both subunit and domain interfaces are relatively smooth compared with other proteins. The interactions of the protein with its co-factor are described and compared among the three structures. Observed changes in co-factor conformation may be related to spectral changes and the energetics of the catalytic reaction. Small but significant adjustments of the protein to changes in co-factor conformation are seen. These adjustments may be accommodated by small rigid-body shifts of secondary structural elements, and by packing defects in the protein core.

-	~~{{STRUCTURE_8aat\| PDB=8aat \| SCENE= }}~~	+	X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase.,McPhalen CA, Vincent MG, Jansonius JN J Mol Biol. 1992 May 20;225(2):495-517. PMID:1593633<ref>PMID:1593633</ref>

-	~~===X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_1593633}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[8aat]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA].~~	+

	==See Also==		==See Also==
	*[[Aspartate Aminotransferase\|Aspartate Aminotransferase]]		*[[Aspartate Aminotransferase\|Aspartate Aminotransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:001593633<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aspartate transaminase]]		[[Category: Aspartate transaminase]]
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Jansonius, J N.]]	+	[[Category: Jansonius, J N]]
-	[[Category: Mcphalen, C A.]]	+	[[Category: Mcphalen, C A]]
-	[[Category: Vincent, M G.]]	+	[[Category: Vincent, M G]]

OCA at 10:10, 20 October 2012

2012-10-20T10:10:55Z

←Older revision		Revision as of 10:10, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[8aat]] is a 2 chain structure ~~of [[Aspartate Aminotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA].	+	[[8aat]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA].

	==See Also==		==See Also==

OCA: Protected "8aat" [edit=sysop:move=sysop]

2012-07-26T01:15:42Z

Protected "8aat" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:15, 26 July 2012

OCA at 01:15, 26 July 2012

2012-07-26T01:15:39Z

←Older revision		Revision as of 01:15, 26 July 2012
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-	{{Seed}}
	[[Image:8aat.png\|left\|200px]]		[[Image:8aat.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_8aat", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_8aat\| PDB=8aat \| SCENE= }}		{{STRUCTURE_8aat\| PDB=8aat \| SCENE= }}

	===X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE===		===X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_1593633}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 1593633 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_1593633}}		{{ABSTRACT_PUBMED_1593633}}

	==About this Structure==		==About this Structure==
-	~~8AAT~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA].	+	[[8aat]] is a 2 chain structure of [[Aspartate Aminotransferase]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA].
		+
		+	==See Also==
		+	*[[Aspartate Aminotransferase\|Aspartate Aminotransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~1593633~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:001593633</ref><references group="xtra"/>
	[[Category: Aspartate transaminase]]		[[Category: Aspartate transaminase]]
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
Line 29:		Line 20:
	[[Category: Mcphalen, C A.]]		[[Category: Mcphalen, C A.]]
	[[Category: Vincent, M G.]]		[[Category: Vincent, M G.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:07:10 2009''

OCA at 20:07, 16 February 2009

2009-02-16T20:07:12Z

←Older revision		Revision as of 20:07, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	8AAT is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA].	+	8AAT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AAT OCA].

	==Reference==		==Reference==
-	~~X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase., McPhalen CA, Vincent MG, Jansonius JN, J Mol Biol. 1992 May 20;225(2):495-517.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/1593633 1593633]~~	+	<ref group="xtra">PMID:1593633</ref><references group="xtra"/>
	[[Category: Aspartate transaminase]]		[[Category: Aspartate transaminase]]
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Single protein]]
	[[Category: Jansonius, J N.]]		[[Category: Jansonius, J N.]]
	[[Category: Mcphalen, C A.]]		[[Category: Mcphalen, C A.]]
	[[Category: Vincent, M G.]]		[[Category: Vincent, M G.]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri Jul 11 12~~:59:~~11 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:07:10 2009''

OCA at 09:59, 11 July 2008

2008-07-11T09:59:12Z

←Older revision		Revision as of 09:59, 11 July 2008
Line 1:		Line 1:
-	[[Image:8aat.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:8aat.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_8aat\| PDB=8aat \| SCENE= }}		{{STRUCTURE_8aat\| PDB=8aat \| SCENE= }}

-	~~'''~~X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE~~'''~~	+	===X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE===


-	~~==Overview==~~	+	<!--
-	~~The X~~-~~ray crystal structures of three forms of the enzyme aspartate aminotransferase (EC 2.6.1.1) from chicken heart mitochondria have been refined by least~~-squares methods: holoenzyme with the co-factor pyridoxal-5'-phosphate bound at pH 7.5 (1.9 A resolution), holoenzyme with pyridoxal-5'-phosphate bound at pH 5.1 (2.3 A resolution) and holoenzyme with the co-factor pyridoxamine-5'-phosphate bound at pH 7.5 (2.2 A resolution). The ~~crystallographic agreement factors [formula: see text] for the structures are 0.166~~, ~~0.130 and 0.131~~, ~~respectively, for all data in~~ the ~~resolution range from 10.0 A~~ to the ~~limit of diffraction for each structure. The secondary, super-secondary and domain structures of the pyridoxal-phosphate holoenzyme~~ at ~~pH 7~~.~~5 are described in detail~~. ~~The surface area of the interface between the monomer subunits of this dimeric alpha 2 protein is unusually large~~, ~~indicating a very stable dimer. This~~ is ~~consistent with biochemical data. Both subunit and domain interfaces are relatively smooth compared with other proteins. The interactions of~~ the ~~protein with its co-factor are described and compared among the three structures~~. ~~Observed changes in co~~-~~factor conformation may be related to spectral changes and the energetics of the catalytic reaction. Small but significant adjustments of the protein to changes in co~~-~~factor conformation are seen. These adjustments may be accommodated by small rigid-body shifts of secondary structural elements, and by packing defects in the protein core.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_1593633}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 1593633 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_1593633}}

	==About this Structure==		==About this Structure==
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	[[Category: Mcphalen, C A.]]		[[Category: Mcphalen, C A.]]
	[[Category: Vincent, M G.]]		[[Category: Vincent, M G.]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 22~~:48:21 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 12:59:11 2008''

OCA at 19:48, 4 May 2008

2008-05-04T19:48:22Z

←Older revision		Revision as of 19:48, 4 May 2008
Line 1:		Line 1:
	[[Image:8aat.gif\|left\|200px]]		[[Image:8aat.gif\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 8aat \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>8aat</scene>~~, ~~resolution 2~~.~~3Å~~	+	The line below this paragraph, containing "STRUCTURE_8aat", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=PLP:PYRIDOXAL~~-~~5'~~-~~PHOSPHATE'>PLP</scene~~>	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	\|~~ACTIVITY~~= ~~<span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span>~~	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_8aat\| PDB=8aat \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aat OCA], [http://www.ebi.ac.uk/pdbsum/8aat PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=8aat RCSB]</span>	+
-	}}	+

	'''X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE'''		'''X-RAY STRUCTURE REFINEMENT AND COMPARISON OF THREE FORMS OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE'''
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	[[Category: Mcphalen, C A.]]		[[Category: Mcphalen, C A.]]
	[[Category: Vincent, M G.]]		[[Category: Vincent, M G.]]
-	~~[[Category: transferase(aminotransferase)]]~~	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:48:21 2008''
-		+
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:44:54 2008''	+