OCA at 08:19, 16 August 2023

2023-08-16T08:19:05Z

←Older revision		Revision as of 08:19, 16 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8ak6 is ~~ON HOLD until Paper Publication~~	+	==Human Sirt6 in complex with ADP-ribose and fragment sulfamethoxazole==
-		+	<StructureSection load='8ak6' size='340' side='right'caption='[[8ak6]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ak6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AK6 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=08D:SULFAMETHOXAZOLE'>08D</scene>, <scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ak6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ak6 OCA], [https://pdbe.org/8ak6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ak6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ak6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ak6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SIR6_HUMAN SIR6_HUMAN] NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.<ref>PMID:18337721</ref> <ref>PMID:19135889</ref> <ref>PMID:19625767</ref> <ref>PMID:20829486</ref> <ref>PMID:21362626</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Steegborn C]]
		+	[[Category: You W]]

OCA at 05:23, 31 August 2022

2022-08-31T05:23:09Z

←Older revision		Revision as of 05:23, 31 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ak6 is ON HOLD	+	The entry 8ak6 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8ak6" [edit=sysop:move=sysop]

2022-08-10T03:54:31Z

Protected "8ak6" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:54, 10 August 2022

OCA: New page: '''Unreleased structure''' The entry 8ak6 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-08-10T03:54:30Z

New page: '''Unreleased structure''' The entry 8ak6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ak6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8ak6 - Revision history

OCA at 08:19, 16 August 2023

OCA at 05:23, 31 August 2022

OCA: Protected "8ak6" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ak6 is ON HOLD Authors: Description: Category: Unreleased Structures