OCA at 10:25, 15 February 2023

2023-02-15T10:25:56Z

←Older revision		Revision as of 10:25, 15 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8amw is ~~ON HOLD until Paper~~ Publication	+	==AQP7 dimer of tetramers_C1==
		+	<StructureSection load='8amw' size='340' side='right'caption='[[8amw]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8amw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AMW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8amw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8amw OCA], [https://pdbe.org/8amw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8amw RCSB], [https://www.ebi.ac.uk/pdbsum/8amw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8amw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. Here, we present the single-particle cryo-EM structure of AQP7 determined at 2.55 A resolution adopting two adhering tetramers, stabilized by extracellularly exposed loops, in a configuration like that of the well-characterized interaction of AQP0 tetramers. The central pore, in-between the four monomers, displays well-defined densities restricted by two leucine filters. Gas chromatography mass spectrometry (GC/MS) results show that the AQP7 sample contains glycerol 3-phosphate (Gro3P), which is compatible with the identified features in the central pore. AQP7 is shown to be highly expressed in human pancreatic alpha- and beta- cells suggesting that the identified AQP7 octamer assembly, in addition to its function as glycerol channel, may serve as junction proteins within the endocrine pancreas.

-	~~Authors~~:	+	Cryo-EM structure supports a role of AQP7 as a junction protein.,Huang P, Venskutonyte R, Prasad RB, Ardalani H, de Mare SW, Fan X, Li P, Spegel P, Yan N, Gourdon P, Artner I, Lindkvist-Petersson K Nat Commun. 2023 Feb 3;14(1):600. doi: 10.1038/s41467-023-36272-y. PMID:36737436<ref>PMID:36737436</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8amw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Fan X]]
		+	[[Category: Gourdon P]]
		+	[[Category: Huang P]]
		+	[[Category: Li P]]
		+	[[Category: Lindkvist-Petersson K]]
		+	[[Category: Venskutonyte R]]
		+	[[Category: Yan N]]

OCA at 05:35, 14 September 2022

2022-09-14T05:35:10Z

←Older revision		Revision as of 05:35, 14 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8amw is ON HOLD	+	The entry 8amw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8amw" [edit=sysop:move=sysop]

2022-08-10T03:58:27Z

Protected "8amw" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:58, 10 August 2022

OCA: New page: '''Unreleased structure''' The entry 8amw is ON HOLD Authors: Description: Category: Unreleased Structures

2022-08-10T03:58:26Z

New page: '''Unreleased structure''' The entry 8amw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8amw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8amw - Revision history

OCA at 10:25, 15 February 2023

OCA at 05:35, 14 September 2022

OCA: Protected "8amw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8amw is ON HOLD Authors: Description: Category: Unreleased Structures