8aqa - Revision history

OCA at 11:23, 15 November 2023

2023-11-15T11:23:59Z

←Older revision		Revision as of 11:23, 15 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8aqa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[8aqa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AQA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDO:6-HYDROXY-L-NORLEUCINE'>LDO</scene>, <scene name='pdbligand=V7T:(2R)-6-azanyl-2-carbamimidamido-hexanoic+acid'>V7T</scene>, <scene name='pdbligand=V8N:2-[3-(aminomethyl)phenyl]ethanoic+acid'>V8N</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDO:6-HYDROXY-L-NORLEUCINE'>LDO</scene>, <scene name='pdbligand=V7T:(2R)-6-azanyl-2-carbamimidamido-hexanoic+acid'>V7T</scene>, <scene name='pdbligand=V8N:2-[3-(aminomethyl)phenyl]ethanoic+acid'>V8N</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8aqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aqa OCA], [https://pdbe.org/8aqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8aqa RCSB], [https://www.ebi.ac.uk/pdbsum/8aqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8aqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8aqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aqa OCA], [https://pdbe.org/8aqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8aqa RCSB], [https://www.ebi.ac.uk/pdbsum/8aqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8aqa ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:27, 21 December 2022

2022-12-21T09:27:09Z

←Older revision		Revision as of 09:27, 21 December 2022
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-	'''Unreleased structure'''

-	~~The entry 8aqa is ON HOLD~~	+	==Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2260==
-		+	<StructureSection load='8aqa' size='340' side='right'caption='[[8aqa]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	~~Authors: Huber, S., Steinmetzer, T.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8aqa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AQA FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2260	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDO:6-HYDROXY-L-NORLEUCINE'>LDO</scene>, <scene name='pdbligand=V7T:(2R)-6-azanyl-2-carbamimidamido-hexanoic+acid'>V7T</scene>, <scene name='pdbligand=V8N:2-[3-(aminomethyl)phenyl]ethanoic+acid'>V8N</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8aqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aqa OCA], [https://pdbe.org/8aqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8aqa RCSB], [https://www.ebi.ac.uk/pdbsum/8aqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8aqa ProSAT]</span></td></tr>
-	[[Category: ~~Steinmetzer, T~~]]	+	</table>
-	[[Category: Huber, S]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Zika virus]]
		+	[[Category: Huber S]]
		+	[[Category: Steinmetzer T]]

OCA: Protected "8aqa" [edit=sysop:move=sysop]

2022-08-18T03:56:44Z

Protected "8aqa" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:56, 18 August 2022

OCA: New page: '''Unreleased structure''' The entry 8aqa is ON HOLD Authors: Huber, S., Steinmetzer, T. Description: Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with In...

2022-08-18T03:56:42Z

New page: '''Unreleased structure''' The entry 8aqa is ON HOLD Authors: Huber, S., Steinmetzer, T. Description: Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with In...

New page

'''Unreleased structure'''

The entry 8aqa is ON HOLD

Authors: Huber, S., Steinmetzer, T.

Description: Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2260
[[Category: Unreleased Structures]]
[[Category: Steinmetzer, T]]
[[Category: Huber, S]]