8au1 - Revision history

OCA at 10:08, 14 December 2022

2022-12-14T10:08:46Z

←Older revision		Revision as of 10:08, 14 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8au1 is ~~ON HOLD until Paper~~ Publication	+	==Jumbo Phage phi-kp24 tail outer sheath==
		+	<StructureSection load='8au1' size='340' side='right'caption='[[8au1]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8au1]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_phage_vB_KpM_FBKp24 Klebsiella phage vB_KpM_FBKp24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AU1 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8au1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8au1 OCA], [https://pdbe.org/8au1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8au1 RCSB], [https://www.ebi.ac.uk/pdbsum/8au1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8au1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A7U0GB71_9CAUD A0A7U0GB71_9CAUD]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Klebsiella jumbo myophage varphiKp24 displays an unusually complex arrangement of tail fibers interacting with a host cell. In this study, we combine cryo-electron microscopy methods, protein structure prediction methods, molecular simulations, microbiological and machine learning approaches to explore the capsid, tail, and tail fibers of varphiKp24. We determine the structure of the capsid and tail at 4.1 A and 3.0 A resolution. We observe the tail fibers are branched and rearranged dramatically upon cell surface attachment. This complex configuration involves fourteen putative tail fibers with depolymerase activity that provide varphiKp24 with the ability to infect a broad panel of capsular polysaccharide (CPS) types of Klebsiella pneumoniae. Our study provides structural and functional insight into how varphiKp24 adapts to the variable surfaces of capsulated bacterial pathogens, which is useful for the development of phage therapy approaches against pan-drug resistant K. pneumoniae strains.

-	~~Authors: Ouyang~~, R., ~~Briegel~~, A.	+	High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.,Ouyang R, Costa AR, Cassidy CK, Otwinowska A, Williams VCJ, Latka A, Stansfeld PJ, Drulis-Kawa Z, Briers Y, Pelt DM, Brouns SJJ, Briegel A Nat Commun. 2022 Nov 24;13(1):7241. doi: 10.1038/s41467-022-34972-5. PMID:36433970<ref>PMID:36433970</ref>

-	~~Description: Jumbo Phage phi~~-~~kp24 tail outer sheath~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Briegel, A]]	+	<div class="pdbe-citations 8au1" style="background-color:#fffaf0;"></div>
-	[[Category: Ouyang, R]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Klebsiella phage vB_KpM_FBKp24]]
		+	[[Category: Large Structures]]
		+	[[Category: Briegel A]]
		+	[[Category: Ouyang R]]

OCA at 07:44, 24 November 2022

2022-11-24T07:44:29Z

←Older revision		Revision as of 07:44, 24 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8au1 is ON HOLD	+	The entry 8au1 is ON HOLD until Paper Publication

	Authors: Ouyang, R., Briegel, A.		Authors: Ouyang, R., Briegel, A.

OCA at 04:31, 28 September 2022

2022-09-28T04:31:38Z

←Older revision		Revision as of 04:31, 28 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8au1 is ON HOLD ~~until sometime in the future~~	+	The entry 8au1 is ON HOLD

	Authors: Ouyang, R., Briegel, A.		Authors: Ouyang, R., Briegel, A.

OCA at 06:27, 21 September 2022

2022-09-21T06:27:53Z

←Older revision		Revision as of 06:27, 21 September 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8au1 is ON HOLD	+	The entry 8au1 is ON HOLD until sometime in the future

	Authors: Ouyang, R., Briegel, A.		Authors: Ouyang, R., Briegel, A.

OCA: Protected "8au1" [edit=sysop:move=sysop]

2022-08-31T05:28:47Z

Protected "8au1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:28, 31 August 2022

OCA: New page: '''Unreleased structure''' The entry 8au1 is ON HOLD Authors: Ouyang, R., Briegel, A. Description: Jumbo Phage phi-kp24 tail outer sheath Category: Unreleased Structures [[Category...

2022-08-31T05:28:46Z

New page: '''Unreleased structure''' The entry 8au1 is ON HOLD Authors: Ouyang, R., Briegel, A. Description: Jumbo Phage phi-kp24 tail outer sheath Category: Unreleased Structures [[Category...

New page

'''Unreleased structure'''

The entry 8au1 is ON HOLD

Authors: Ouyang, R., Briegel, A.

Description: Jumbo Phage phi-kp24 tail outer sheath
[[Category: Unreleased Structures]]
[[Category: Briegel, A]]
[[Category: Ouyang, R]]