8b8b - Revision history

OCA at 07:57, 1 May 2024

2024-05-01T07:57:19Z

←Older revision		Revision as of 07:57, 1 May 2024
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8b OCA], [https://pdbe.org/8b8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8b RCSB], [https://www.ebi.ac.uk/pdbsum/8b8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8b OCA], [https://pdbe.org/8b8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8b RCSB], [https://www.ebi.ac.uk/pdbsum/8b8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8b ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Determining the structural organisation of viral replication complexes and unravelling the impact of infection on cellular homeostasis represent important challenges in virology. This may prove particularly useful when confronted with viruses that pose a significant threat to human health, that appear unique within their family, or for which knowledge is scarce. Among Mononegavirales, bornaviruses (family Bornaviridae) stand out due to their compact genomes and their nuclear localisation for replication. The recent recognition of the zoonotic potential of several orthobornaviruses has sparked a surge of interest in improving our knowledge on this viral family. In this work, we provide a complete analysis of the structural organisation of Borna disease virus 1 (BoDV-1) phosphoprotein (P), an important cofactor for polymerase activity. Using X-ray diffusion and diffraction experiments, we revealed that BoDV-1 P adopts a long coiled-coil alpha-helical structure split into two parts by an original beta-strand twist motif, which is highly conserved across the members of whole Orthobornavirus genus and may regulate viral replication. In parallel, we used BioID to determine the proximal interactome of P in living cells. We confirmed previously known interactors and identified novel proteins linked to several biological processes such as DNA repair or mRNA metabolism. Altogether, our study provides important structure/function cues, which may improve our understanding of BoDV-1 pathogenesis.
-
-	Borna Disease Virus 1 Phosphoprotein Forms a Tetramer and Interacts with Host Factors Involved in DNA Double-Strand Break Repair and mRNA Processing.,Tarbouriech N, Chenavier F, Kawasaki J, Bachiri K, Bourhis JM, Legrand P, Freslon LL, Laurent EMN, Suberbielle E, Ruigrok RWH, Tomonaga K, Gonzalez-Dunia D, Horie M, Coyaud E, Crepin T Viruses. 2022 Oct 26;14(11):2358. doi: 10.3390/v14112358. PMID:36366462<ref>PMID:36366462</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 8b8b" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:25, 15 November 2023

2023-11-15T11:25:15Z

←Older revision		Revision as of 11:25, 15 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8b8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthobornavirus_serini Orthobornavirus serini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B8B FirstGlance]. <br>		<table><tr><td colspan='2'>[[8b8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthobornavirus_serini Orthobornavirus serini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B8B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8b OCA], [https://pdbe.org/8b8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8b RCSB], [https://www.ebi.ac.uk/pdbsum/8b8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8b OCA], [https://pdbe.org/8b8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8b RCSB], [https://www.ebi.ac.uk/pdbsum/8b8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8b ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:14, 24 November 2022

2022-11-24T10:14:30Z

←Older revision		Revision as of 10:14, 24 November 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8b8b is ~~ON HOLD until Paper~~ Publication	+	==Multimerization domain of Munia virus 1 phosphoprotein==
		+	<StructureSection load='8b8b' size='340' side='right'caption='[[8b8b]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8b8b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthobornavirus_serini Orthobornavirus serini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B8B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8b OCA], [https://pdbe.org/8b8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8b RCSB], [https://www.ebi.ac.uk/pdbsum/8b8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8b ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Determining the structural organisation of viral replication complexes and unravelling the impact of infection on cellular homeostasis represent important challenges in virology. This may prove particularly useful when confronted with viruses that pose a significant threat to human health, that appear unique within their family, or for which knowledge is scarce. Among Mononegavirales, bornaviruses (family Bornaviridae) stand out due to their compact genomes and their nuclear localisation for replication. The recent recognition of the zoonotic potential of several orthobornaviruses has sparked a surge of interest in improving our knowledge on this viral family. In this work, we provide a complete analysis of the structural organisation of Borna disease virus 1 (BoDV-1) phosphoprotein (P), an important cofactor for polymerase activity. Using X-ray diffusion and diffraction experiments, we revealed that BoDV-1 P adopts a long coiled-coil alpha-helical structure split into two parts by an original beta-strand twist motif, which is highly conserved across the members of whole Orthobornavirus genus and may regulate viral replication. In parallel, we used BioID to determine the proximal interactome of P in living cells. We confirmed previously known interactors and identified novel proteins linked to several biological processes such as DNA repair or mRNA metabolism. Altogether, our study provides important structure/function cues, which may improve our understanding of BoDV-1 pathogenesis.

-	~~Authors: Chenavier, F~~., Tarbouriech, N., ~~Bourhis~~, J~~.M.~~, ~~Tomonaga~~, K., ~~Horie~~, M., ~~Crepin~~, T.	+	Borna Disease Virus 1 Phosphoprotein Forms a Tetramer and Interacts with Host Factors Involved in DNA Double-Strand Break Repair and mRNA Processing.,Tarbouriech N, Chenavier F, Kawasaki J, Bachiri K, Bourhis JM, Legrand P, Freslon LL, Laurent EMN, Suberbielle E, Ruigrok RWH, Tomonaga K, Gonzalez-Dunia D, Horie M, Coyaud E, Crepin T Viruses. 2022 Oct 26;14(11):2358. doi: 10.3390/v14112358. PMID:36366462<ref>PMID:36366462</ref>

-	~~Description: Multimerization domain~~ of ~~Munia virus 1 phosphoprotein~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Bourhis, J.M~~]]	+	<div class="pdbe-citations 8b8b" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Tarbouriech, N~~]]	+	== References ==
-	[[Category: Chenavier, F]]	+	<references/>
-	[[Category: Crepin, T]]	+	__TOC__
-	[[Category: ~~Tomonaga, K~~]]	+	</StructureSection>
-	[[Category: ~~Horie, M~~]]	+	[[Category: Large Structures]]
		+	[[Category: Orthobornavirus serini]]
		+	[[Category: Bourhis JM]]
		+	[[Category: Chenavier F]]
		+	[[Category: Crepin T]]
		+	[[Category: Horie M]]
		+	[[Category: Tarbouriech N]]
		+	[[Category: Tomonaga K]]

OCA: Protected "8b8b" [edit=sysop:move=sysop]

2022-10-19T16:52:46Z

Protected "8b8b" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:52, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8b8b is ON HOLD until Paper Publication Authors: Chenavier, F., Tarbouriech, N., Bourhis, J.M., Tomonaga, K., Horie, M., Crepin, T. Description: Mu...

2022-10-19T16:52:45Z

New page: '''Unreleased structure''' The entry 8b8b is ON HOLD until Paper Publication Authors: Chenavier, F., Tarbouriech, N., Bourhis, J.M., Tomonaga, K., Horie, M., Crepin, T. Description: Mu...

New page

'''Unreleased structure'''

The entry 8b8b is ON HOLD until Paper Publication

Authors: Chenavier, F., Tarbouriech, N., Bourhis, J.M., Tomonaga, K., Horie, M., Crepin, T.

Description: Multimerization domain of Munia virus 1 phosphoprotein
[[Category: Unreleased Structures]]
[[Category: Bourhis, J.M]]
[[Category: Tarbouriech, N]]
[[Category: Chenavier, F]]
[[Category: Crepin, T]]
[[Category: Tomonaga, K]]
[[Category: Horie, M]]