8bb4 - Revision history

OCA at 11:07, 22 November 2023

2023-11-22T11:07:02Z

←Older revision		Revision as of 11:07, 22 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8bb4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BB4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8bb4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BB4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q3R:~{N}-[5-[4-[[4-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-4-oxidanylidene-butyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanyl-4-(trifluoromethyl)pyridine-3-carboxamide'>Q3R</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q3R:~{N}-[5-[4-[[4-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-4-oxidanylidene-butyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanyl-4-(trifluoromethyl)pyridine-3-carboxamide'>Q3R</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bb4 OCA], [https://pdbe.org/8bb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bb4 RCSB], [https://www.ebi.ac.uk/pdbsum/8bb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bb4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bb4 OCA], [https://pdbe.org/8bb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bb4 RCSB], [https://www.ebi.ac.uk/pdbsum/8bb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bb4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>		[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
		+
		+	==See Also==
		+	*[[Elongation factor 3D structures\|Elongation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:32, 9 November 2022

2022-11-09T07:32:48Z

←Older revision		Revision as of 07:32, 9 November 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8bb4 is ~~ON HOLD~~	+	==Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with C3 linker==
-		+	<StructureSection load='8bb4' size='340' side='right'caption='[[8bb4]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Kraemer~~, A., ~~Doelle~~, A., ~~Knapp, S~~., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8bb4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BB4 FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~human WDR5~~ and ~~pVHL~~:~~ElonginC~~:~~ElonginB bound~~ to ~~PROTAC with C3 linker~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q3R:~{N}-[5-[4-[[4-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-4-oxidanylidene-butyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanyl-4-(trifluoromethyl)pyridine-3-carboxamide'>Q3R</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bb4 OCA], [https://pdbe.org/8bb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bb4 RCSB], [https://www.ebi.ac.uk/pdbsum/8bb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bb4 ProSAT]</span></td></tr>
-	[[Category: ~~Knapp, S~~]]	+	</table>
-	[[Category: ~~Structural Genomics Consortium (Sgc)~~]]	+	== Function ==
-	[[Category: ~~Doelle, A~~]]	+	[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
-	[[Category: Kraemer, A]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Doelle A]]
		+	[[Category: Knapp S]]
		+	[[Category: Kraemer A]]

OCA: Protected "8bb4" [edit=sysop:move=sysop]

2022-10-19T17:03:32Z

Protected "8bb4" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:03, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8bb4 is ON HOLD Authors: Kraemer, A., Doelle, A., Knapp, S., Structural Genomics Consortium (SGC) Description: Structure of human WDR5 and pVHL:Elo...

2022-10-19T17:03:31Z

New page: '''Unreleased structure''' The entry 8bb4 is ON HOLD Authors: Kraemer, A., Doelle, A., Knapp, S., Structural Genomics Consortium (SGC) Description: Structure of human WDR5 and pVHL:Elo...

New page

'''Unreleased structure'''

The entry 8bb4 is ON HOLD

Authors: Kraemer, A., Doelle, A., Knapp, S., Structural Genomics Consortium (SGC)

Description: Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with C3 linker
[[Category: Unreleased Structures]]
[[Category: Knapp, S]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Doelle, A]]
[[Category: Kraemer, A]]