OCA at 09:27, 21 December 2022

2022-12-21T09:27:51Z

←Older revision		Revision as of 09:27, 21 December 2022
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-	'''Unreleased structure'''

-	The entry ~~8bbe~~ is ~~ON HOLD~~	+	==Structure of the IFT-A complex; IFT-A2 module==
		+	<StructureSection load='8bbe' size='340' side='right'caption='[[8bbe]], [[Resolution\|resolution]] 3.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8bbe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBE FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bbe OCA], [https://pdbe.org/8bbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bbe RCSB], [https://www.ebi.ac.uk/pdbsum/8bbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bbe ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/IFT43_HUMAN IFT43_HUMAN] Cranioectodermal dysplasia. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IFT43_HUMAN IFT43_HUMAN] As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (PubMed:28400947, PubMed:28973684). Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (PubMed:21378380).<ref>PMID:21378380</ref> <ref>PMID:28400947</ref> <ref>PMID:28973684</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Intraflagellar transport (IFT) trains are massive molecular machines that traffic proteins between cilia and the cell body. Each IFT train is a dynamic polymer of two large complexes (IFT-A and -B) and motor proteins, posing a formidable challenge to mechanistic understanding. Here, we reconstituted the complete human IFT-A complex and obtained its structure using cryo-EM. Combined with AlphaFold prediction and genome-editing studies, our results illuminate how IFT-A polymerizes, interacts with IFT-B, and uses an array of beta-propeller and TPR domains to create "carriages" of the IFT train that engage TULP adaptor proteins. We show that IFT-AâTULP carriages are essential for cilia localization of diverse membrane proteins, as well as ICK-the key kinase regulating IFT train turnaround. These data establish a structural link between IFT-A's distinct functions, provide a blueprint for IFT-A in the train, and shed light on how IFT evolved from a proto-coatomer ancestor.

-	~~Authors~~:	+	IFT-A structure reveals carriages for membrane protein transport into cilia.,Hesketh SJ, Mukhopadhyay AG, Nakamura D, Toropova K, Roberts AJ Cell. 2022 Nov 30:S0092-8674(22)01422-2. doi: 10.1016/j.cell.2022.11.010. PMID:36462505<ref>PMID:36462505</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8bbe" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Hesketh SJ]]
		+	[[Category: Mukhopadhyay AG]]
		+	[[Category: Nakamura D]]
		+	[[Category: Roberts AJ]]
		+	[[Category: Toropova K]]

OCA: Protected "8bbe" [edit=sysop:move=sysop]

2022-10-19T17:03:55Z

Protected "8bbe" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:03, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8bbe is ON HOLD Authors: Description: Category: Unreleased Structures

2022-10-19T17:03:54Z

New page: '''Unreleased structure''' The entry 8bbe is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8bbe is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8bbe - Revision history

OCA at 09:27, 21 December 2022

OCA: Protected "8bbe" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8bbe is ON HOLD Authors: Description: Category: Unreleased Structures