8bda - Revision history

OCA at 12:51, 26 July 2023

2023-07-26T12:51:20Z

←Older revision		Revision as of 12:51, 26 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8bda]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BDA FirstGlance]. <br>		<table><tr><td colspan='2'>[[8bda]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BDA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bda OCA], [https://pdbe.org/8bda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bda RCSB], [https://www.ebi.ac.uk/pdbsum/8bda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bda ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 20.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bda OCA], [https://pdbe.org/8bda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bda RCSB], [https://www.ebi.ac.uk/pdbsum/8bda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:39, 11 January 2023

2023-01-11T07:39:26Z

←Older revision		Revision as of 07:39, 11 January 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8bda is ~~ON HOLD until Paper~~ Publication	+	==IFTA complex in anterograde Intraflagellar transport trains (Chlamydomonas reinhardtii)==
		+	<StructureSection load='8bda' size='340' side='right'caption='[[8bda]], [[Resolution\|resolution]] 20.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8bda]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BDA FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bda OCA], [https://pdbe.org/8bda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bda RCSB], [https://www.ebi.ac.uk/pdbsum/8bda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bda ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8JFR3_CHLRE A8JFR3_CHLRE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and signaling cargos to microtubule motors for import into cilia. It remains unknown how the IFT-A/-B proteins are arranged into complexes and how these complexes polymerize into functional trains. Here we use in situ cryo-electron tomography of Chlamydomonas reinhardtii cilia and AlphaFold2 protein structure predictions to generate a molecular model of the entire anterograde train. We show how the conformations of both IFT-A and IFT-B are dependent on lateral interactions with neighboring repeats, suggesting that polymerization is required to cooperatively stabilize the complexes. Following three-dimensional classification, we reveal how IFT-B extends two flexible tethers to maintain a connection with IFT-A that can withstand the mechanical stresses present in actively beating cilia. Overall, our findings provide a framework for understanding the fundamental processes that govern cilia assembly.

-	~~Authors~~:	+	The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains.,Lacey SE, Foster HE, Pigino G Nat Struct Mol Biol. 2023 Jan 2. doi: 10.1038/s41594-022-00905-5. PMID:36593313<ref>PMID:36593313</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8bda" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chlamydomonas reinhardtii]]
		+	[[Category: Large Structures]]
		+	[[Category: Foster HE]]
		+	[[Category: Lacey SE]]
		+	[[Category: Pigino G]]

OCA at 05:06, 7 December 2022

2022-12-07T05:06:17Z

←Older revision		Revision as of 05:06, 7 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bda is ON HOLD	+	The entry 8bda is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8bda" [edit=sysop:move=sysop]

2022-10-26T03:54:09Z

Protected "8bda" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:54, 26 October 2022

OCA: New page: '''Unreleased structure''' The entry 8bda is ON HOLD Authors: Description: Category: Unreleased Structures

2022-10-26T03:54:08Z

New page: '''Unreleased structure''' The entry 8bda is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8bda is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]