8bgw - Revision history

OCA at 08:20, 16 August 2023

2023-08-16T08:20:07Z

←Older revision		Revision as of 08:20, 16 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8bgw is ~~ON HOLD until Paper~~ Publication	+	==CryoEM structure of quinol-dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans at 2.2 A resolution==
		+	<StructureSection load='8bgw' size='340' side='right'caption='[[8bgw]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8bgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Achromobacter_xylosoxidans Achromobacter xylosoxidans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BGW FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10M:DECYL+4-O-ALPHA-D-GLUCOPYRANOSYL-1-THIO-BETA-D-GLUCOPYRANOSIDE'>10M</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LOP:(1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>LOP</scene>, <scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bgw OCA], [https://pdbe.org/8bgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bgw RCSB], [https://www.ebi.ac.uk/pdbsum/8bgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bgw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0D6H8R3_ALCXX A0A0D6H8R3_ALCXX]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Quinol-dependent nitric oxide reductases (qNORs) are considered members of the respiratory heme-copper oxidase superfamily, are unique to bacteria, and are commonly found in pathogenic bacteria where they play a role in combating the host immune response. qNORs are also essential enzymes in the denitrification pathway, catalysing the reduction of nitric oxide to nitrous oxide. Here, we determine a 2.2 A cryoEM structure of qNOR from Alcaligenes xylosoxidans, an opportunistic pathogen and a denitrifying bacterium of importance in the nitrogen cycle. This high-resolution structure provides insight into electron, substrate, and proton pathways, and provides evidence that the quinol binding site not only contains the conserved His and Asp residues but also possesses a critical Arg (Arg720) observed in cytochrome bo(3), a respiratory quinol oxidase.

-	~~Authors: Flynn,~~ A., Antonyuk~~, S.V.~~, Eady~~, R.R.~~, Muench, S.P.~~, Hasnain, S~~.S.	+	A 2.2 A cryoEM structure of a quinol-dependent NO Reductase shows close similarity to respiratory oxidases.,Flynn AJ, Antonyuk SV, Eady RR, Muench SP, Hasnain SS Nat Commun. 2023 Jun 9;14(1):3416. doi: 10.1038/s41467-023-39140-x. PMID:37296134<ref>PMID:37296134</ref>

-	~~Description: CryoEM structure~~ of ~~quinol-dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans at 2~~.~~2 A resolution~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Muench, S.P~~]]	+	<div class="pdbe-citations 8bgw" style="background-color:#fffaf0;"></div>
-	[[Category: Antonyuk~~, S.V~~]]	+	== References ==
-	[[Category: Eady~~, R.R~~]]	+	<references/>
-	[[Category: Flynn, A]]	+	__TOC__
-	[[Category: Hasnain~~, S.S~~]]	+	</StructureSection>
		+	[[Category: Achromobacter xylosoxidans]]
		+	[[Category: Large Structures]]
		+	[[Category: Antonyuk SV]]
		+	[[Category: Eady RR]]
		+	[[Category: Flynn A]]
		+	[[Category: Hasnain SS]]
		+	[[Category: Muench SP]]

OCA at 09:04, 1 February 2023

2023-02-01T09:04:50Z

←Older revision		Revision as of 09:04, 1 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bgw is ON HOLD	+	The entry 8bgw is ON HOLD until Paper Publication

	Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S.		Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S.

OCA at 04:47, 25 January 2023

2023-01-25T04:47:53Z

←Older revision		Revision as of 04:47, 25 January 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bgw is ON HOLD ~~until Paper Publication~~	+	The entry 8bgw is ON HOLD

	Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S.		Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S.
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	Description: CryoEM structure of quinol-dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans at 2.2 A resolution		Description: CryoEM structure of quinol-dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans at 2.2 A resolution
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Eady, R.R]]
-	[[Category: Hasnain, S.S]]
	[[Category: Muench, S.P]]		[[Category: Muench, S.P]]
	[[Category: Antonyuk, S.V]]		[[Category: Antonyuk, S.V]]
		+	[[Category: Eady, R.R]]
	[[Category: Flynn, A]]		[[Category: Flynn, A]]
		+	[[Category: Hasnain, S.S]]

OCA at 07:15, 14 December 2022

2022-12-14T07:15:33Z

←Older revision		Revision as of 07:15, 14 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bgw is ON HOLD	+	The entry 8bgw is ON HOLD until Paper Publication

	Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S.		Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S.
Line 7:		Line 7:
	Description: CryoEM structure of quinol-dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans at 2.2 A resolution		Description: CryoEM structure of quinol-dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans at 2.2 A resolution
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Eady, R.R]]
		+	[[Category: Hasnain, S.S]]
	[[Category: Muench, S.P]]		[[Category: Muench, S.P]]
	[[Category: Antonyuk, S.V]]		[[Category: Antonyuk, S.V]]
-	[[Category: Eady, R.R]]
	[[Category: Flynn, A]]		[[Category: Flynn, A]]
-	[[Category: Hasnain, S.S]]

OCA: Protected "8bgw" [edit=sysop:move=sysop]

2022-11-09T04:52:33Z

Protected "8bgw" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:52, 9 November 2022

OCA: New page: '''Unreleased structure''' The entry 8bgw is ON HOLD Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S. Description: CryoEM structure of quinol-dependent Nitri...

2022-11-09T04:52:29Z

New page: '''Unreleased structure''' The entry 8bgw is ON HOLD Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S. Description: CryoEM structure of quinol-dependent Nitri...

New page

'''Unreleased structure'''

The entry 8bgw is ON HOLD

Authors: Flynn, A., Antonyuk, S.V., Eady, R.R., Muench, S.P., Hasnain, S.S.

Description: CryoEM structure of quinol-dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans at 2.2 A resolution
[[Category: Unreleased Structures]]
[[Category: Muench, S.P]]
[[Category: Antonyuk, S.V]]
[[Category: Eady, R.R]]
[[Category: Flynn, A]]
[[Category: Hasnain, S.S]]