OCA at 13:51, 29 November 2023

2023-11-29T13:51:40Z

←Older revision		Revision as of 13:51, 29 November 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8boc ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 19==
-		+	<StructureSection load='8boc' size='340' side='right'caption='[[8boc]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~Authors~~: ~~Linhard~~, V., ~~Witt~~, K., ~~Gande~~, S., ~~Wollenhaupt~~, J., ~~Lennartz, F~~., ~~Weiss~~, M.S., ~~Schwalbe~~, H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8boc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BOC FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure~~ of ~~Ephrin A2~~ (~~EphA2~~) ~~Receptor Protein Kinase with Compound 19~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUF:~{N}-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide'>QUF</scene></td></tr>
-	[[Category: ~~Linhard, V~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8boc OCA], [https://pdbe.org/8boc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8boc RCSB], [https://www.ebi.ac.uk/pdbsum/8boc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8boc ProSAT]</span></td></tr>
-	[[Category: ~~Wollenhaupt, J~~]]	+	</table>
-	[[Category: ~~Gande, S~~]]	+	== Disease ==
-	[[Category: ~~Witt, K~~]]	+	[https://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN] Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[https://omim.org/entry/613020 613020]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.<ref>PMID:19573808</ref> <ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[https://omim.org/entry/116600 116600]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:19573808</ref> <ref>PMID:19005574</ref> <ref>PMID:19306328</ref> <ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.<ref>PMID:19573808</ref>
-	[[Category: Schwalbe, H]]	+	== Function ==
-	[[Category: ~~Lennartz, F~~]]	+	[https://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.<ref>PMID:10655584</ref> <ref>PMID:16236711</ref> <ref>PMID:18339848</ref> <ref>PMID:19573808</ref> <ref>PMID:20679435</ref> <ref>PMID:20861311</ref>
-	[[Category: ~~Weiss, M.S~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Gande S]]
		+	[[Category: Lennartz F]]
		+	[[Category: Linhard V]]
		+	[[Category: Schwalbe H]]
		+	[[Category: Weiss MS]]
		+	[[Category: Witt K]]
		+	[[Category: Wollenhaupt J]]

OCA: Protected "8boc" [edit=sysop:move=sysop]

2022-11-24T08:03:27Z

Protected "8boc" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:03, 24 November 2022

OCA: New page: '''Unreleased structure''' The entry 8boc is ON HOLD until Paper Publication Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H. Descrip...

2022-11-24T08:03:26Z

New page: '''Unreleased structure''' The entry 8boc is ON HOLD until Paper Publication Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H. Descrip...

New page

'''Unreleased structure'''

The entry 8boc is ON HOLD until Paper Publication

Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H.

Description: Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 19
[[Category: Unreleased Structures]]
[[Category: Linhard, V]]
[[Category: Wollenhaupt, J]]
[[Category: Gande, S]]
[[Category: Witt, K]]
[[Category: Schwalbe, H]]
[[Category: Lennartz, F]]
[[Category: Weiss, M.S]]

8boc - Revision history

OCA at 13:51, 29 November 2023

OCA: Protected "8boc" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8boc is ON HOLD until Paper Publication Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H. Descrip...