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8bw1 - Revision history
2026-04-10T16:53:29Z
Revision history for this page on the wiki
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OCA at 09:59, 20 December 2023
2023-12-20T09:59:26Z
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<td colspan='2' style="background-color: white; color:black;">←Older revision</td>
<td colspan='2' style="background-color: white; color:black;">Revision as of 09:59, 20 December 2023</td>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">The entry </del>8bw1 <del style="color: red; font-weight: bold; text-decoration: none;">is ON HOLD </del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==Yeast 20S proteasome in complex with an engineered fellutamide derivative (C14QAL)==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><StructureSection load='</ins>8bw1<ins style="color: red; font-weight: bold; text-decoration: none;">' size='340' side='right'caption='[[8bw1]], [[Resolution|resolution]] 3.25&Aring;' scene=''></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Authors</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Bozhueyuek, K</del>.<del style="color: red; font-weight: bold; text-decoration: none;">A</del>.<del style="color: red; font-weight: bold; text-decoration: none;">J</del>.<del style="color: red; font-weight: bold; text-decoration: none;">, Praeve, L</del>.<del style="color: red; font-weight: bold; text-decoration: none;">, Kegler, C</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Kaiser, S</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Shi</del>, <del style="color: red; font-weight: bold; text-decoration: none;">Y</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Kuttenlochner, W</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Schenk, L</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Groll, M</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Hochberg, G</del>.<del style="color: red; font-weight: bold; text-decoration: none;">K</del>.<del style="color: red; font-weight: bold; text-decoration: none;">A</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Bode, H</del>.<del style="color: red; font-weight: bold; text-decoration: none;">B</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><table><tr><td colspan='2'>[[8bw1]] is a 20 chain structure with sequence from [https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//en</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">wikipedia</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]</ins>. <ins style="color: red; font-weight: bold; text-decoration: none;">Full crystallographic information is available from [http://oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac.il/oca-bin/ocashort?id=8BW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BW1 FirstGlance]. <br></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Description</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Yeast 20S </del>proteasome in complex with an <del style="color: red; font-weight: bold; text-decoration: none;">engineered fellutamide derivative (C14QAL)</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[[Resolution|Resolution]] 3</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">25&#8491;</td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Unreleased </del>Structures]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=DCL:2-AMINO-4-METHYL-PENTAN-1-OL'>DCL</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Kuttenlochner, W</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/fgij/fg.htm?mol=8bw1 FirstGlance]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann.ac.il/oca-bin/ocaids?id=8bw1 OCA]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://pdbe</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/8bw1 PDBe]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">rcsb.org/pdb/explore.do?structureId=8bw1 RCSB]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ebi</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">uk/pdbsum/8bw1 PDBsum]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://prosat</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">h-its</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/prosat/prosatexe?pdbcode=8bw1 ProSAT]</span></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Praeve, L</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></table></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Bozhueyuek<del style="color: red; font-weight: bold; text-decoration: none;">, K.A.J</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Function ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Hochberg, G.K.A</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The </ins>proteasome <ins style="color: red; font-weight: bold; text-decoration: none;">degrades poly-ubiquitinated proteins </ins>in <ins style="color: red; font-weight: bold; text-decoration: none;">the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase </ins>complex <ins style="color: red; font-weight: bold; text-decoration: none;">that is characterized by its ability to cleave peptides </ins>with <ins style="color: red; font-weight: bold; text-decoration: none;">Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has </ins>an <ins style="color: red; font-weight: bold; text-decoration: none;">ATP-dependent proteolytic activity.</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Schenk, L</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Groll, M</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></StructureSection></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Kegler<del style="color: red; font-weight: bold; text-decoration: none;">, </del>C]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Large </ins>Structures]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Shi, Y</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Saccharomyces cerevisiae</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Kaiser, S</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Bode HB</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Bode, H.B</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Bozhueyuek <ins style="color: red; font-weight: bold; text-decoration: none;">KAJ</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Groll M</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Hochberg GKA</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Kaiser S</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Kegler C]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Kuttenlochner W</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Praeve L</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Schenk L]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Shi Y</ins>]]</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=8bw1&diff=3680317&oldid=prev
OCA: Protected "8bw1" [edit=sysop:move=sysop]
2022-12-14T07:24:57Z
<p>Protected "<a href="/wiki/index.php/8bw1" title="8bw1">8bw1</a>" [edit=sysop:move=sysop]</p>
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<td colspan='2' style="background-color: white; color:black;">Revision as of 07:24, 14 December 2022</td>
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OCA
http://52.214.119.220/wiki/index.php?title=8bw1&diff=3680316&oldid=prev
OCA: New page: '''Unreleased structure''' The entry 8bw1 is ON HOLD Authors: Bozhueyuek, K.A.J., Praeve, L., Kegler, C., Kaiser, S., Shi, Y., Kuttenlochner, W., Schenk, L., Groll, M., Hochberg, G.K.A....
2022-12-14T07:24:56Z
<p>New page: '''Unreleased structure''' The entry 8bw1 is ON HOLD Authors: Bozhueyuek, K.A.J., Praeve, L., Kegler, C., Kaiser, S., Shi, Y., Kuttenlochner, W., Schenk, L., Groll, M., Hochberg, G.K.A....</p>
<p><b>New page</b></p><div>'''Unreleased structure'''<br />
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The entry 8bw1 is ON HOLD <br />
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Authors: Bozhueyuek, K.A.J., Praeve, L., Kegler, C., Kaiser, S., Shi, Y., Kuttenlochner, W., Schenk, L., Groll, M., Hochberg, G.K.A., Bode, H.B.<br />
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Description: Yeast 20S proteasome in complex with an engineered fellutamide derivative (C14QAL)<br />
[[Category: Unreleased Structures]]<br />
[[Category: Kuttenlochner, W]]<br />
[[Category: Praeve, L]]<br />
[[Category: Bozhueyuek, K.A.J]]<br />
[[Category: Hochberg, G.K.A]]<br />
[[Category: Schenk, L]]<br />
[[Category: Groll, M]]<br />
[[Category: Kegler, C]]<br />
[[Category: Shi, Y]]<br />
[[Category: Kaiser, S]]<br />
[[Category: Bode, H.B]]</div>
OCA