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8byl - Revision history
2026-04-09T19:23:58Z
Revision history for this page on the wiki
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http://52.214.119.220/wiki/index.php?title=8byl&diff=3796212&oldid=prev
OCA at 21:14, 28 June 2023
2023-06-28T21:14:57Z
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">The entry </del>8byl is <del style="color: red; font-weight: bold; text-decoration: none;">ON HOLD until Paper Publication</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><StructureSection load='</ins>8byl<ins style="color: red; font-weight: bold; text-decoration: none;">' size='340' side='right'caption='[[8byl]], [[Resolution|resolution]] 3.50&Aring;' scene=''></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Authors</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Rowland</del>, <del style="color: red; font-weight: bold; text-decoration: none;">R</del>.<del style="color: red; font-weight: bold; text-decoration: none;">J</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Salamina, M</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Endicott, J</del>.<del style="color: red; font-weight: bold; text-decoration: none;">A</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Noble, M</del>.<del style="color: red; font-weight: bold; text-decoration: none;">E</del>.<del style="color: red; font-weight: bold; text-decoration: none;">M</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><table><tr><td colspan='2'>[[8byl]] </ins>is <ins style="color: red; font-weight: bold; text-decoration: none;">a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BYL FirstGlance]. <br></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Description</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Cryo</del>-<del style="color: red; font-weight: bold; text-decoration: none;">EM structure </del>of <del style="color: red; font-weight: bold; text-decoration: none;">SKP1</del>-<del style="color: red; font-weight: bold; text-decoration: none;">SKP2</del>-<del style="color: red; font-weight: bold; text-decoration: none;">CKS1 from </del>the <del style="color: red; font-weight: bold; text-decoration: none;">SCFSKP2 E3 ligase </del>complex</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Unreleased </del>Structures]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Endicott<del style="color: red; font-weight: bold; text-decoration: none;">, J.A</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8byl FirstGlance]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac.il/oca-bin/ocaids?id=8byl OCA]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://pdbe</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/8byl PDBe]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">rcsb</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/pdb/explore.do?structureId=8byl RCSB]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ebi</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">uk/pdbsum/8byl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8byl ProSAT]</span></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Noble<del style="color: red; font-weight: bold; text-decoration: none;">, M.E.M</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></table></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Rowland<del style="color: red; font-weight: bold; text-decoration: none;">, R.J</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Disease ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Salamina<del style="color: red; font-weight: bold; text-decoration: none;">, </del>M]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//www.uniprot.org/uniprot/CDN1B_HUMAN CDN1B_HUMAN] Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:[https://omim.org/entry/610755 610755]. Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">like syndrome with a phenotypic overlap </ins>of <ins style="color: red; font-weight: bold; text-decoration: none;">both MEN1 and MEN2.<ref>PMID:17030811</ref> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Function ==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[https://www.uniprot.org/uniprot/CDN1B_HUMAN CDN1B_HUMAN] Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E</ins>- <ins style="color: red; font-weight: bold; text-decoration: none;">and cyclin A</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in </ins>the <ins style="color: red; font-weight: bold; text-decoration: none;">assembly, stability, and modulation of CCND1-CDK4 </ins>complex <ins style="color: red; font-weight: bold; text-decoration: none;">activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.<ref>PMID:10831586</ref> <ref>PMID:12244301</ref> <ref>PMID:16782892</ref> <ref>PMID:19075005</ref> <ref>PMID:17254966</ref> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><references/></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></StructureSection></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Homo sapiens]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Large </ins>Structures]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Endicott <ins style="color: red; font-weight: bold; text-decoration: none;">JA</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Noble <ins style="color: red; font-weight: bold; text-decoration: none;">MEM</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Rowland <ins style="color: red; font-weight: bold; text-decoration: none;">RJ</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Salamina M]]</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=8byl&diff=3697635&oldid=prev
OCA at 04:51, 18 January 2023
2023-01-18T04:51:08Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 04:51, 18 January 2023</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The entry 8byl is ON HOLD </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The entry 8byl is ON HOLD <ins style="color: red; font-weight: bold; text-decoration: none;"> until Paper Publication</ins></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Rowland, R.J., Salamina, M., Endicott, J.A., Noble, M.E.M.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Rowland, R.J., Salamina, M., Endicott, J.A., Noble, M.E.M.</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=8byl&diff=3684129&oldid=prev
OCA: Protected "8byl" [edit=sysop:move=sysop]
2022-12-21T06:11:14Z
<p>Protected "<a href="/wiki/index.php/8byl" title="8byl">8byl</a>" [edit=sysop:move=sysop]</p>
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<td colspan='2' style="background-color: white; color:black;">Revision as of 06:11, 21 December 2022</td>
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OCA
http://52.214.119.220/wiki/index.php?title=8byl&diff=3684128&oldid=prev
OCA: New page: '''Unreleased structure''' The entry 8byl is ON HOLD Authors: Rowland, R.J., Salamina, M., Endicott, J.A., Noble, M.E.M. Description: Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSK...
2022-12-21T06:11:08Z
<p>New page: '''Unreleased structure''' The entry 8byl is ON HOLD Authors: Rowland, R.J., Salamina, M., Endicott, J.A., Noble, M.E.M. Description: Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSK...</p>
<p><b>New page</b></p><div>'''Unreleased structure'''<br />
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The entry 8byl is ON HOLD <br />
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Authors: Rowland, R.J., Salamina, M., Endicott, J.A., Noble, M.E.M.<br />
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Description: Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex<br />
[[Category: Unreleased Structures]]<br />
[[Category: Endicott, J.A]]<br />
[[Category: Noble, M.E.M]]<br />
[[Category: Rowland, R.J]]<br />
[[Category: Salamina, M]]</div>
OCA