8ci0 - Revision history

OCA at 12:52, 26 July 2023

2023-07-26T12:52:08Z

←Older revision		Revision as of 12:52, 26 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8ci0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CI0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8ci0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CI0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EL:2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2H-1,3-thiazol-5-yl]ethyl+phosphono+hydrogen+phosphate'>8EL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene>, <scene name='pdbligand=UP0:(1~{Z},3~{R},4~{S},7~{S},8~{Z})-8-ethylidene-4,7-bis(oxidanyl)-5-oxidanylidene-3-propyl-cyclononene-1,2-dicarboxylic+acid'>UP0</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.902Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EL:2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2H-1,3-thiazol-5-yl]ethyl+phosphono+hydrogen+phosphate'>8EL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene>, <scene name='pdbligand=UP0:(1~{Z},3~{R},4~{S},7~{S},8~{Z})-8-ethylidene-4,7-bis(oxidanyl)-5-oxidanylidene-3-propyl-cyclononene-1,2-dicarboxylic+acid'>UP0</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ci0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ci0 OCA], [https://pdbe.org/8ci0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ci0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ci0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ci0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ci0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ci0 OCA], [https://pdbe.org/8ci0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ci0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ci0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ci0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:22, 22 March 2023

2023-03-22T07:22:53Z

←Older revision		Revision as of 07:22, 22 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8ci0 is ~~ON HOLD until Paper~~ Publication	+	==Maize Transketolase in complex with TPP and hydrolyzed (+)-Cornexistin==
		+	<StructureSection load='8ci0' size='340' side='right'caption='[[8ci0]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8ci0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CI0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EL:2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2H-1,3-thiazol-5-yl]ethyl+phosphono+hydrogen+phosphate'>8EL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene>, <scene name='pdbligand=UP0:(1~{Z},3~{R},4~{S},7~{S},8~{Z})-8-ethylidene-4,7-bis(oxidanyl)-5-oxidanylidene-3-propyl-cyclononene-1,2-dicarboxylic+acid'>UP0</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ci0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ci0 OCA], [https://pdbe.org/8ci0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ci0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ci0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ci0 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TKTC_MAIZE TKTC_MAIZE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the design, synthesis and biological evaluation of simplified analogues of the herbicidal natural product (+)-cornexistin. Guided by an X-Ray co-crystal structure of cornexistin bound to the transketolase enzyme from Zea mays, we attempted to identify the key interactions that are necessary for cornexistin to maintain its herbicidal profile. This resulted in the preparation of three novel analogues investigating the importance of substituents that are located on the nine-membered ring of cornexistin. One analogue maintained a good level of biological activity and could provide researchers insights in how to further optimize the structure of cornexistin for commercialization in the future.

-	~~Authors: Freigang~~, J.	+	Investigations into Simplified Analogues of the Herbicidal Natural Product (+)-Cornexistin.,Steinborn C, Tancredi A, Habiger C, Diederich C, Kramer J, Reingruber A, Laber B, Freigang J, Lange G, Schmutzler D, Machettira A, Besong G, Magauer T, Barber DM Chemistry. 2023 Feb 20:e202300199. doi: 10.1002/chem.202300199. PMID:36807428<ref>PMID:36807428</ref>

-	~~Description: Maize Transketolase in complex with TPP and hydrolyzed (+)~~-~~Cornexistin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Freigang, J]]	+	<div class="pdbe-citations 8ci0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Zea mays]]
		+	[[Category: Freigang J]]

OCA at 07:28, 15 March 2023

2023-03-15T07:28:24Z

←Older revision		Revision as of 07:28, 15 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ci0 is ON HOLD	+	The entry 8ci0 is ON HOLD until Paper Publication

	Authors: Freigang, J.		Authors: Freigang, J.

OCA: Protected "8ci0" [edit=sysop:move=sysop]

2023-02-15T08:38:21Z

Protected "8ci0" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:38, 15 February 2023

OCA: New page: '''Unreleased structure''' The entry 8ci0 is ON HOLD Authors: Freigang, J. Description: Maize Transketolase in complex with TPP and hydrolyzed (+)-Cornexistin [[Category: Unreleased St...

2023-02-15T08:38:20Z

New page: '''Unreleased structure''' The entry 8ci0 is ON HOLD Authors: Freigang, J. Description: Maize Transketolase in complex with TPP and hydrolyzed (+)-Cornexistin [[Category: Unreleased St...

New page

'''Unreleased structure'''

The entry 8ci0 is ON HOLD

Authors: Freigang, J.

Description: Maize Transketolase in complex with TPP and hydrolyzed (+)-Cornexistin
[[Category: Unreleased Structures]]
[[Category: Freigang, J]]