8cni - Revision history

OCA at 13:10, 1 March 2024

2024-03-01T13:10:19Z

←Older revision		Revision as of 13:10, 1 March 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cni OCA], [https://pdbe.org/8cni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cni RCSB], [https://www.ebi.ac.uk/pdbsum/8cni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cni ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cni OCA], [https://pdbe.org/8cni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cni RCSB], [https://www.ebi.ac.uk/pdbsum/8cni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cni ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5. Persistent stimulation of this signalling pathway is known to be involved in the pathogenesis of systemic lupus erythematosus (SLE). Understanding how PHT1 recruits TASL at the molecular level, is therefore clinically important for the development of therapeutics against SLE and other autoimmune diseases. Here we present the Cryo-EM structure of PHT1 stabilized in the outward-open conformation. By combining biochemical and structural modeling techniques we propose a model of the PHT1-TASL complex, in which the first 16 N-terminal TASL residues fold into a helical structure that bind in the central cavity of the inward-open conformation of PHT1. This work provides critical insights into the molecular basis of PHT1/TASL mediated type I interferon production.
-
-	Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1.,Custodio TF, Killer M, Yu D, Puente V, Teufel DP, Pautsch A, Schnapp G, Grundl M, Kosinski J, Low C Nat Commun. 2023 Sep 14;14(1):5696. doi: 10.1038/s41467-023-41420-5. PMID:37709742<ref>PMID:37709742</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 8cni" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:54, 27 September 2023

2023-09-27T06:54:31Z

←Older revision		Revision as of 06:54, 27 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8cni is ~~ON HOLD until Paper~~ Publication	+	==PHT1 in the outward facing conformation, bound to Sb27==
		+	<StructureSection load='8cni' size='340' side='right'caption='[[8cni]], [[Resolution\|resolution]] 3.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8cni]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CNI FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.35Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cni OCA], [https://pdbe.org/8cni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cni RCSB], [https://www.ebi.ac.uk/pdbsum/8cni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cni ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5. Persistent stimulation of this signalling pathway is known to be involved in the pathogenesis of systemic lupus erythematosus (SLE). Understanding how PHT1 recruits TASL at the molecular level, is therefore clinically important for the development of therapeutics against SLE and other autoimmune diseases. Here we present the Cryo-EM structure of PHT1 stabilized in the outward-open conformation. By combining biochemical and structural modeling techniques we propose a model of the PHT1-TASL complex, in which the first 16 N-terminal TASL residues fold into a helical structure that bind in the central cavity of the inward-open conformation of PHT1. This work provides critical insights into the molecular basis of PHT1/TASL mediated type I interferon production.

-	~~Authors: Custodio~~, T., Killer, M., ~~Loew~~, C.	+	Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1.,Custodio TF, Killer M, Yu D, Puente V, Teufel DP, Pautsch A, Schnapp G, Grundl M, Kosinski J, Low C Nat Commun. 2023 Sep 14;14(1):5696. doi: 10.1038/s41467-023-41420-5. PMID:37709742<ref>PMID:37709742</ref>

-	~~Description: PHT1 in the outward facing conformation~~, ~~bound to Sb27~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Custodio, T]]	+	<div class="pdbe-citations 8cni" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Loew, C~~]]	+	== References ==
-	[[Category: ~~Killer, M~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Custodio T]]
		+	[[Category: Killer M]]
		+	[[Category: Loew C]]

OCA at 04:48, 7 April 2023

2023-04-07T04:48:43Z

←Older revision		Revision as of 04:48, 7 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cni is ON HOLD	+	The entry 8cni is ON HOLD until Paper Publication

	Authors: Custodio, T., Killer, M., Loew, C.		Authors: Custodio, T., Killer, M., Loew, C.
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	Description: PHT1 in the outward facing conformation, bound to Sb27		Description: PHT1 in the outward facing conformation, bound to Sb27
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Custodio, T]]
	[[Category: Loew, C]]		[[Category: Loew, C]]
	[[Category: Killer, M]]		[[Category: Killer, M]]
-	[[Category: Custodio, T]]

OCA at 07:30, 15 March 2023

2023-03-15T07:30:24Z

←Older revision		Revision as of 07:30, 15 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cni is ON HOLD ~~until sometime in the future~~	+	The entry 8cni is ON HOLD

	Authors: Custodio, T., Killer, M., Loew, C.		Authors: Custodio, T., Killer, M., Loew, C.
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	Description: PHT1 in the outward facing conformation, bound to Sb27		Description: PHT1 in the outward facing conformation, bound to Sb27
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Custodio, T]]
	[[Category: Loew, C]]		[[Category: Loew, C]]
	[[Category: Killer, M]]		[[Category: Killer, M]]
		+	[[Category: Custodio, T]]

OCA at 05:34, 8 March 2023

2023-03-08T05:34:31Z

←Older revision		Revision as of 05:34, 8 March 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cni is ON HOLD	+	The entry 8cni is ON HOLD until sometime in the future

	Authors: Custodio, T., Killer, M., Loew, C.		Authors: Custodio, T., Killer, M., Loew, C.

OCA: Protected "8cni" [edit=sysop:move=sysop]

2023-03-02T04:23:15Z

Protected "8cni" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:23, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8cni is ON HOLD Authors: Custodio, T., Killer, M., Loew, C. Description: PHT1 in the outward facing conformation, bound to Sb27 [[Category: Unrelea...

2023-03-02T04:23:14Z

New page: '''Unreleased structure''' The entry 8cni is ON HOLD Authors: Custodio, T., Killer, M., Loew, C. Description: PHT1 in the outward facing conformation, bound to Sb27 [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 8cni is ON HOLD

Authors: Custodio, T., Killer, M., Loew, C.

Description: PHT1 in the outward facing conformation, bound to Sb27
[[Category: Unreleased Structures]]
[[Category: Custodio, T]]
[[Category: Loew, C]]
[[Category: Killer, M]]