OCA at 06:53, 10 May 2023

2023-05-10T06:53:05Z

←Older revision		Revision as of 06:53, 10 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8ctc is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Human excitatory amino acid transporter 3 (EAAT3) with bound glutamate in an intermediate outward facing state==
-		+	<StructureSection load='8ctc' size='340' side='right'caption='[[8ctc]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ctc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CTC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ctc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ctc OCA], [https://pdbe.org/8ctc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ctc RCSB], [https://www.ebi.ac.uk/pdbsum/8ctc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ctc ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EAA3_HUMAN EAA3_HUMAN] Hot water reflex epilepsy;Dicarboxylic aminoaciduria. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed:21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed:23341099).<ref>PMID:21982423</ref> <ref>PMID:23341099</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EAA3_HUMAN EAA3_HUMAN] Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949, PubMed:33658209). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:33658209). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity).[UniProtKB:P51906][UniProtKB:P51907]<ref>PMID:21123949</ref> <ref>PMID:26690923</ref> <ref>PMID:33658209</ref> <ref>PMID:7521911</ref> <ref>PMID:7914198</ref> <ref>PMID:8857541</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Boudker O]]
		+	[[Category: Qiu B]]

OCA at 06:24, 29 June 2022

2022-06-29T06:24:21Z

←Older revision		Revision as of 06:24, 29 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ctc is ON HOLD	+	The entry 8ctc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8ctc" [edit=sysop:move=sysop]

2022-05-25T06:58:51Z

Protected "8ctc" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 25 May 2022

OCA: New page: '''Unreleased structure''' The entry 8ctc is ON HOLD Authors: Description: Category: Unreleased Structures

2022-05-25T06:58:50Z

New page: '''Unreleased structure''' The entry 8ctc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ctc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8ctc - Revision history

OCA at 06:53, 10 May 2023

OCA at 06:24, 29 June 2022

OCA: Protected "8ctc" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ctc is ON HOLD Authors: Description: Category: Unreleased Structures