OCA at 09:26, 19 April 2023

2023-04-19T09:26:19Z

←Older revision		Revision as of 09:26, 19 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8d4x is ~~ON HOLD until Paper Publication~~	+	==Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a dimeric form==
-		+	<StructureSection load='8d4x' size='340' side='right'caption='[[8d4x]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8d4x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D4X FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d4x OCA], [https://pdbe.org/8d4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d4x RCSB], [https://www.ebi.ac.uk/pdbsum/8d4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d4x ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UBR5_HUMAN UBR5_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.<ref>PMID:21127351</ref> <ref>PMID:21726808</ref> <ref>PMID:22884692</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: He Q]]
		+	[[Category: Li H]]
		+	[[Category: Lin G]]
		+	[[Category: Wang F]]

OCA at 08:06, 24 November 2022

2022-11-24T08:06:19Z

←Older revision		Revision as of 08:06, 24 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8d4x is ON HOLD	+	The entry 8d4x is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 18:04, 16 November 2022

2022-11-16T18:04:19Z

←Older revision		Revision as of 18:04, 16 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8d4x is ON HOLD ~~until Paper Publication~~	+	The entry 8d4x is ON HOLD

	Authors:		Authors:

OCA at 15:10, 6 July 2022

2022-07-06T15:10:17Z

←Older revision		Revision as of 15:10, 6 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8d4x is ON HOLD	+	The entry 8d4x is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8d4x" [edit=sysop:move=sysop]

2022-06-08T04:37:31Z

Protected "8d4x" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:37, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 8d4x is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-08T04:37:30Z

New page: '''Unreleased structure''' The entry 8d4x is ON HOLD Authors: Description: Category: Unreleased Structures

New page