8d56 - Revision history

OCA at 07:34, 12 July 2023

2023-07-12T07:34:57Z

←Older revision		Revision as of 07:34, 12 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8d56]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D56 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8d56]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D56 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d56 OCA], [https://pdbe.org/8d56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d56 RCSB], [https://www.ebi.ac.uk/pdbsum/8d56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d56 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d56 OCA], [https://pdbe.org/8d56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d56 RCSB], [https://www.ebi.ac.uk/pdbsum/8d56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d56 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 05:39, 7 June 2023

2023-06-07T05:39:18Z

←Older revision		Revision as of 05:39, 7 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8d56 is ~~ON HOLD~~	+	==One RBD-up state of SARS-CoV-2 BA.2 variant spike protein==
-		+	<StructureSection load='8d56' size='340' side='right'caption='[[8d56]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8d56]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D56 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d56 OCA], [https://pdbe.org/8d56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d56 RCSB], [https://www.ebi.ac.uk/pdbsum/8d56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d56 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Chen B]]
		+	[[Category: Gao HL]]
		+	[[Category: Peng HQ]]
		+	[[Category: Shi W]]
		+	[[Category: Tang WC]]
		+	[[Category: Volloch SR]]
		+	[[Category: Xiao TS]]
		+	[[Category: Zhang J]]

OCA: Protected "8d56" [edit=sysop:move=sysop]

2022-06-15T04:10:32Z

Protected "8d56" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:10, 15 June 2022

OCA: New page: '''Unreleased structure''' The entry 8d56 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-15T04:10:31Z

New page: '''Unreleased structure''' The entry 8d56 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8d56 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]