OCA at 07:34, 8 March 2023

2023-03-08T07:34:42Z

←Older revision		Revision as of 07:34, 8 March 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8de9 is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPE mixed micelles==
		+	<StructureSection load='8de9' size='340' side='right'caption='[[8de9]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8de9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DE9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEV:(1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PEV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8de9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8de9 OCA], [https://pdbe.org/8de9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8de9 RCSB], [https://www.ebi.ac.uk/pdbsum/8de9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8de9 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and shape cellular excitability. For the mechanosensitive subfamily of K2Ps, the composition of phospholipids within the bilayer strongly influences channel activity. To examine the molecular details of K2P lipid modulation, we solved cryo-EM structures of the TREK1 K2P channel bound to either the anionic lipid phosphatidic acid (PA) or the zwitterionic lipid phosphatidylethanolamine (PE). At the extracellular face of TREK1, a PA lipid inserts its hydrocarbon tail into a pocket behind the selectivity filter, causing a structural rearrangement that recapitulates mutations and pharmacology known to activate TREK1. At the cytoplasmic face, PA and PE lipids compete to modulate the conformation of the TREK1 TM4 gating helix. Our findings demonstrate two distinct pathways by which anionic lipids enhance TREK1 activity and provide a framework for a model that integrates lipid gating with the effects of other mechanosensitive K2P modulators.

-	~~Authors~~:	+	Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.,Schmidpeter PAM, Petroff JT 2nd, Khajoueinejad L, Wague A, Frankfater C, Cheng WWL, Nimigean CM, Riegelhaupt PM Nat Commun. 2023 Feb 25;14(1):1077. doi: 10.1038/s41467-023-36765-w. PMID:36841877<ref>PMID:36841877</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8de9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Danio rerio]]
		+	[[Category: Large Structures]]
		+	[[Category: Nimigean CM]]
		+	[[Category: Riegelhaupt PM]]
		+	[[Category: Schmidpeter PAM]]

OCA at 04:23, 2 March 2023

2023-03-02T04:23:51Z

←Older revision		Revision as of 04:23, 2 March 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8de9 is ON HOLD	+	The entry 8de9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 09:21, 1 February 2023

2023-02-01T09:21:01Z

←Older revision		Revision as of 09:21, 1 February 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8de9 is ON HOLD ~~until Paper Publication~~	+	The entry 8de9 is ON HOLD

	Authors:		Authors:

OCA at 03:47, 25 August 2022

2022-08-25T03:47:25Z

←Older revision		Revision as of 03:47, 25 August 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8de9 is ON HOLD	+	The entry 8de9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8de9" [edit=sysop:move=sysop]

2022-06-29T06:30:48Z

Protected "8de9" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:30, 29 June 2022

OCA: New page: '''Unreleased structure''' The entry 8de9 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-29T06:30:47Z

New page: '''Unreleased structure''' The entry 8de9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page