8dey - Revision history

OCA at 10:08, 25 October 2023

2023-10-25T10:08:44Z

←Older revision		Revision as of 10:08, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8dey]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DEY FirstGlance]. <br>		<table><tr><td colspan='2'>[[8dey]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DEY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LWK:(3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione'>LWK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LWK:(3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione'>LWK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dey OCA], [https://pdbe.org/8dey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dey RCSB], [https://www.ebi.ac.uk/pdbsum/8dey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dey ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dey OCA], [https://pdbe.org/8dey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dey RCSB], [https://www.ebi.ac.uk/pdbsum/8dey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dey ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:34, 8 March 2023

2023-03-08T07:34:43Z

←Older revision		Revision as of 07:34, 8 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8dey is ~~ON HOLD until Paper Publication~~	+	==Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709==
-		+	<StructureSection load='8dey' size='340' side='right'caption='[[8dey]], [[Resolution\|resolution]] 3.70Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8dey]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DEY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LWK:(3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione'>LWK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dey OCA], [https://pdbe.org/8dey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dey RCSB], [https://www.ebi.ac.uk/pdbsum/8dey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dey ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Autosomal recessive nonsyndromic intellectual deficit;Distal monosomy 3p. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.<ref>PMID:18414909</ref> <ref>PMID:20223979</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Clifton MC]]
		+	[[Category: Ma X]]

OCA at 18:04, 16 November 2022

2022-11-16T18:04:24Z

←Older revision		Revision as of 18:04, 16 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dey is ON HOLD	+	The entry 8dey is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dey" [edit=sysop:move=sysop]

2022-06-29T06:32:10Z

Protected "8dey" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:32, 29 June 2022

OCA: New page: '''Unreleased structure''' The entry 8dey is ON HOLD Authors: Description: Category: Unreleased Structures

2022-06-29T06:32:09Z

New page: '''Unreleased structure''' The entry 8dey is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dey is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]