OCA at 07:48, 21 September 2022

2022-09-21T07:48:55Z

←Older revision		Revision as of 07:48, 21 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8dkm is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of cystine-bound cystinosin in a lumen-open state==
-		+	<StructureSection load='8dkm' size='340' side='right'caption='[[8dkm]], [[Resolution\|resolution]] 3.39Å' scene=''>
-	~~Authors~~: ~~Schmiege~~, P., Li, X.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8dkm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DKM FirstGlance]. <br>
-	~~Description~~: ~~Cystinosin~~ Cystine-~~bound Lumen~~-~~open~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IYY:L-cystine'>IYY</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dkm OCA], [https://pdbe.org/8dkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dkm RCSB], [https://www.ebi.ac.uk/pdbsum/8dkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dkm ProSAT]</span></td></tr>
-	[[Category: ~~Schmiege, P~~]]	+	</table>
-	[[Category: Li, X]]	+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/CTNS_HUMAN CTNS_HUMAN]] Juvenile nephropathic cystinosis;Ocular cystinosis;Infantile nephropathic cystinosis. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/CTNS_HUMAN CTNS_HUMAN]] Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:11689434, PubMed:18337546, PubMed:22232659, PubMed:29467429, PubMed:33208952, PubMed:15128704). Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis (PubMed:22649030). In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes (By similarity). Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity (By similarity).[UniProtKB:P57757]<ref>PMID:11689434</ref> <ref>PMID:15128704</ref> <ref>PMID:18337546</ref> <ref>PMID:22232659</ref> <ref>PMID:22649030</ref> <ref>PMID:29467429</ref> <ref>PMID:33208952</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Li X]]
		+	[[Category: Schmiege P]]

OCA at 04:27, 20 July 2022

2022-07-20T04:27:20Z

←Older revision		Revision as of 04:27, 20 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dkm is ON HOLD	+	The entry 8dkm is ON HOLD until Paper Publication

	Authors: Schmiege, P., Li, X.		Authors: Schmiege, P., Li, X.

OCA: Protected "8dkm" [edit=sysop:move=sysop]

2022-07-13T04:17:38Z

Protected "8dkm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:17, 13 July 2022

OCA: New page: '''Unreleased structure''' The entry 8dkm is ON HOLD Authors: Schmiege, P., Li, X. Description: Cystinosin Cystine-bound Lumen-open Category: Unreleased Structures [[Category: Schm...

2022-07-13T04:17:37Z

New page: '''Unreleased structure''' The entry 8dkm is ON HOLD Authors: Schmiege, P., Li, X. Description: Cystinosin Cystine-bound Lumen-open Category: Unreleased Structures [[Category: Schm...

New page

'''Unreleased structure'''

The entry 8dkm is ON HOLD

Authors: Schmiege, P., Li, X.

Description: Cystinosin Cystine-bound Lumen-open
[[Category: Unreleased Structures]]
[[Category: Schmiege, P]]
[[Category: Li, X]]

8dkm - Revision history

OCA at 07:48, 21 September 2022

OCA at 04:27, 20 July 2022

OCA: Protected "8dkm" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8dkm is ON HOLD Authors: Schmiege, P., Li, X. Description: Cystinosin Cystine-bound Lumen-open Category: Unreleased Structures [[Category: Schm...