OCA at 06:36, 25 January 2023

2023-01-25T06:36:16Z

←Older revision		Revision as of 06:36, 25 January 2023
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-	'''Unreleased structure'''

-	The entry ~~8dl6~~ is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc==
		+	<StructureSection load='8dl6' size='340' side='right'caption='[[8dl6]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8dl6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DL6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dl6 OCA], [https://pdbe.org/8dl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dl6 RCSB], [https://www.ebi.ac.uk/pdbsum/8dl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dl6 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Hemochromatosis type 4. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15692071). Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).[UniProtKB:Q9JHI9]<ref>PMID:15692071</ref> <ref>PMID:22682227</ref> <ref>PMID:29237594</ref> <ref>PMID:32814342</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ferroportin (Fpn) is a transporter that releases ferrous ion (Fe(2+)) from cells and is important for homeostasis of iron in circulation. Export of one Fe(2+) by Fpn is coupled to import of two H(+) to maintain charge balance. Here we show that human Fpn (HsFpn) binds to and mediates Ca(2+) transport. We determine the structure of Ca(2+)-bound HsFpn and identify a single Ca(2+) binding site distinct from the Fe(2+) binding sites. Further studies validate the Ca(2+) binding site and show that Ca(2+) transport is not coupled to transport of another ion. In addition, Ca(2+) transport is significantly inhibited in the presence of Fe(2+) but not vice versa. Function of Fpn as a Ca(2+) uniporter may allow regulation of iron homeostasis by Ca(2+).

-	~~Authors: Shen~~, J., Wilbon, ~~A.S.~~, Pan, Y.~~, Zhou, M~~.	+	Mechanism of Ca(2+) transport by ferroportin.,Shen J, Wilbon AS, Zhou M, Pan Y Elife. 2023 Jan 17;12:e82947. doi: 10.7554/eLife.82947. PMID:36648329<ref>PMID:36648329</ref>

-	~~Description: Cryo-EM structure~~ of ~~human ferroportin~~/~~slc40 bound to Ca2+ in nanodisc~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Pan, Y]]	+	<div class="pdbe-citations 8dl6" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Wilbon, A.S~~]]	+	== References ==
-	[[Category: ~~Zhou, M~~]]	+	<references/>
-	[[Category: ~~Shen, J~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Pan Y]]
		+	[[Category: Shen J]]
		+	[[Category: Wilbon AS]]
		+	[[Category: Zhou M]]

OCA at 05:30, 31 August 2022

2022-08-31T05:30:51Z

←Older revision		Revision as of 05:30, 31 August 2022
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	The entry 8dl6 is ON HOLD until Paper Publication		The entry 8dl6 is ON HOLD until Paper Publication

-	Authors: Shen, J., ~~Wilson~~, A.S., Pan, Y., Zhou, M.	+	Authors: Shen, J., Wilbon, A.S., Pan, Y., Zhou, M.

	Description: Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc		Description: Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Pan, Y]]		[[Category: Pan, Y]]
-	[[Category: ~~Wilson~~, A.S]]	+	[[Category: Wilbon, A.S]]
	[[Category: Zhou, M]]		[[Category: Zhou, M]]
	[[Category: Shen, J]]		[[Category: Shen, J]]

OCA: Protected "8dl6" [edit=sysop:move=sysop]

2022-07-13T04:18:41Z

Protected "8dl6" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 13 July 2022

OCA: New page: '''Unreleased structure''' The entry 8dl6 is ON HOLD until Paper Publication Authors: Shen, J., Wilson, A.S., Pan, Y., Zhou, M. Description: Cryo-EM structure of human ferroportin/slc4...

2022-07-13T04:18:40Z

New page: '''Unreleased structure''' The entry 8dl6 is ON HOLD until Paper Publication Authors: Shen, J., Wilson, A.S., Pan, Y., Zhou, M. Description: Cryo-EM structure of human ferroportin/slc4...

New page

'''Unreleased structure'''

The entry 8dl6 is ON HOLD until Paper Publication

Authors: Shen, J., Wilson, A.S., Pan, Y., Zhou, M.

Description: Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc
[[Category: Unreleased Structures]]
[[Category: Pan, Y]]
[[Category: Wilson, A.S]]
[[Category: Zhou, M]]
[[Category: Shen, J]]

8dl6 - Revision history

OCA at 06:36, 25 January 2023

OCA at 05:30, 31 August 2022

OCA: Protected "8dl6" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8dl6 is ON HOLD until Paper Publication Authors: Shen, J., Wilson, A.S., Pan, Y., Zhou, M. Description: Cryo-EM structure of human ferroportin/slc4...