OCA at 05:56, 11 October 2023

2023-10-11T05:56:26Z

←Older revision		Revision as of 05:56, 11 October 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8dn5 is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state1(open state)==
-		+	<StructureSection load='8dn5' size='340' side='right'caption='[[8dn5]], [[Resolution\|resolution]] 3.63Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8dn5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DN5 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.63Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=DD9:NONANE'>DD9</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NBU:N-BUTANE'>NBU</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=UND:UNDECANE'>UND</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dn5 OCA], [https://pdbe.org/8dn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dn5 RCSB], [https://www.ebi.ac.uk/pdbsum/8dn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dn5 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GLRB_HUMAN GLRB_HUMAN] Hereditary hyperekplexia. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GLRB_HUMAN GLRB_HUMAN] Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).<ref>PMID:11929858</ref> <ref>PMID:15302677</ref> <ref>PMID:16144831</ref> <ref>PMID:22715885</ref> <ref>PMID:23238346</ref> <ref>PMID:25445488</ref> <ref>PMID:8717357</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aequorea victoria]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Liu X]]
		+	[[Category: Wang W]]

OCA at 10:38, 26 July 2023

2023-07-26T10:38:35Z

←Older revision		Revision as of 10:38, 26 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dn5 is ON HOLD	+	The entry 8dn5 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dn5" [edit=sysop:move=sysop]

2022-07-20T04:31:08Z

Protected "8dn5" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 20 July 2022

OCA: New page: '''Unreleased structure''' The entry 8dn5 is ON HOLD Authors: Description: Category: Unreleased Structures

2022-07-20T04:31:05Z

New page: '''Unreleased structure''' The entry 8dn5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dn5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8dn5 - Revision history

OCA at 05:56, 11 October 2023

OCA at 10:38, 26 July 2023

OCA: Protected "8dn5" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8dn5 is ON HOLD Authors: Description: Category: Unreleased Structures