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8dnd - Revision history
2026-04-12T13:46:35Z
Revision history for this page on the wiki
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http://52.214.119.220/wiki/index.php?title=8dnd&diff=3814162&oldid=prev
OCA at 10:36, 2 August 2023
2023-08-02T10:36:51Z
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">The entry </del>8dnd is <del style="color: red; font-weight: bold; text-decoration: none;">ON HOLD until Paper Publication</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920)==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><StructureSection load='</ins>8dnd<ins style="color: red; font-weight: bold; text-decoration: none;">' size='340' side='right'caption='[[8dnd]], [[Resolution|resolution]] 2.02&Aring;' scene=''></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Authors</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Salvador</del>, <del style="color: red; font-weight: bold; text-decoration: none;">G</del>.<del style="color: red; font-weight: bold; text-decoration: none;">H</del>.<del style="color: red; font-weight: bold; text-decoration: none;">M</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Fontes</del>, <del style="color: red; font-weight: bold; text-decoration: none;">M</del>.<del style="color: red; font-weight: bold; text-decoration: none;">R</del>.<del style="color: red; font-weight: bold; text-decoration: none;">M</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><table><tr><td colspan='2'>[[8dnd]] </ins>is <ins style="color: red; font-weight: bold; text-decoration: none;">a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_pirajai Bothrops pirajai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DND FirstGlance]. <br></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Description</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Crystal structure of Bothrops pirajai Piratoxin-I </del>(<del style="color: red; font-weight: bold; text-decoration: none;">PrTX-I</del>) and <del style="color: red; font-weight: bold; text-decoration: none;">synthetic inhibitor Varespladib </del>(<del style="color: red; font-weight: bold; text-decoration: none;">LY315920</del>)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.018&#8491;</td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Unreleased Structures</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=VRD:({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic+acid'>VRD</scene></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Salvador, G.H.M</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/fgij/fg</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">htm?mol=8dnd FirstGlance], [http://oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann.ac.il/oca-bin/ocaids?id=8dnd OCA]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://pdbe.org/8dnd PDBe]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">rcsb</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/pdb/explore</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">do?structureId=8dnd RCSB], [https://www.ebi.ac.uk/pdbsum/8dnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dnd ProSAT]</span></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Fontes<del style="color: red; font-weight: bold; text-decoration: none;">, M.R.M</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></table></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Function ==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//www.uniprot.org/uniprot/PA2H1_BOTPI PA2H1_BOTPI] Snake venom phospholipase A2 </ins>(<ins style="color: red; font-weight: bold; text-decoration: none;">PLA2</ins>) <ins style="color: red; font-weight: bold; text-decoration: none;">homolog that lacks enzymatic activity, but displays myotoxin </ins>and <ins style="color: red; font-weight: bold; text-decoration: none;">edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid </ins>(<ins style="color: red; font-weight: bold; text-decoration: none;">RA</ins>)<ins style="color: red; font-weight: bold; text-decoration: none;">.<ref>PMID:7660366</ref> <ref>PMID:22205953</ref> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><references/></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></StructureSection></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Bothrops pirajai</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Large Structures</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Fontes <ins style="color: red; font-weight: bold; text-decoration: none;">MRM]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Salvador GHM</ins>]]</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=8dnd&diff=3645134&oldid=prev
OCA at 17:05, 19 October 2022
2022-10-19T17:05:34Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 17:05, 19 October 2022</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The entry 8dnd is ON HOLD </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The entry 8dnd is ON HOLD <ins style="color: red; font-weight: bold; text-decoration: none;"> until Paper Publication</ins></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Salvador, G.H.M., Fontes, M.R.M.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Salvador, G.H.M., Fontes, M.R.M.</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=8dnd&diff=3592509&oldid=prev
OCA: Protected "8dnd" [edit=sysop:move=sysop]
2022-07-20T04:31:48Z
<p>Protected "<a href="/wiki/index.php/8dnd" title="8dnd">8dnd</a>" [edit=sysop:move=sysop]</p>
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<td colspan='2' style="background-color: white; color:black;">Revision as of 04:31, 20 July 2022</td>
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OCA
http://52.214.119.220/wiki/index.php?title=8dnd&diff=3592508&oldid=prev
OCA: New page: '''Unreleased structure''' The entry 8dnd is ON HOLD Authors: Salvador, G.H.M., Fontes, M.R.M. Description: Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inh...
2022-07-20T04:31:46Z
<p>New page: '''Unreleased structure''' The entry 8dnd is ON HOLD Authors: Salvador, G.H.M., Fontes, M.R.M. Description: Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inh...</p>
<p><b>New page</b></p><div>'''Unreleased structure'''<br />
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The entry 8dnd is ON HOLD <br />
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Authors: Salvador, G.H.M., Fontes, M.R.M.<br />
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Description: Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920)<br />
[[Category: Unreleased Structures]]<br />
[[Category: Salvador, G.H.M]]<br />
[[Category: Fontes, M.R.M]]</div>
OCA