OCA at 21:17, 28 June 2023

2023-06-28T21:17:27Z

←Older revision		Revision as of 21:17, 28 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8e49 ~~is ON HOLD until Paper Publication~~	+	==E. coli 50S ribosome bound to antibiotic analog SLC31==
-		+	<StructureSection load='8e49' size='340' side='right'caption='[[8e49]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~Authors~~: ~~Pellegrino~~, J., ~~Lee~~, D.J., ~~Fraser~~, J.S., ~~Seiple~~, I.B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8e49]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E49 FirstGlance]. <br>
-	~~Description~~: E. coli ~~50S~~ ribosome ~~bound~~ to ~~antibiotic analog SLC31~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MG:1N-METHYLGUANOSINE-5-MONOPHOSPHATE'>1MG</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=3TD:(1S)-1,4-ANHYDRO-1-(3-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-5-O-PHOSPHONO-D-RIBITOL'>3TD</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UH0:~{N}-[[(5~{S})-3-[3-fluoranyl-4-[6-(2-methyl-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl]-2-oxidanylidene-1,3-oxazolidin-5-yl]methyl]-2-[methyl-[(2~{R},3~{R},4~{S},6~{R})-6-methyl-2,3-bis(oxidanyl)oxan-4-yl]amino]ethanamide'>UH0</scene></td></tr>
-	[[Category: ~~Seiple, I.B~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e49 OCA], [https://pdbe.org/8e49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e49 RCSB], [https://www.ebi.ac.uk/pdbsum/8e49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e49 ProSAT]</span></td></tr>
-	[[Category: Lee~~, D.J~~]]	+	</table>
-	[[Category: ~~Fraser,~~ J.S]]	+	== Function ==
-	[[Category: ~~Pellegrino, J~~]]	+	[https://www.uniprot.org/uniprot/RL2_ECOLI RL2_ECOLI] One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial.[HAMAP-Rule:MF_01320_B] In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G.[HAMAP-Rule:MF_01320_B]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
		+	[[Category: Fraser JS]]
		+	[[Category: Lee DJ]]
		+	[[Category: Pellegrino J]]
		+	[[Category: Seiple IB]]

OCA at 06:34, 21 September 2022

2022-09-21T06:34:17Z

←Older revision		Revision as of 06:34, 21 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8e49 is ON HOLD	+	The entry 8e49 is ON HOLD until Paper Publication

	Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.		Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.
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	Description: E. coli 50S ribosome bound to antibiotic analog SLC31		Description: E. coli 50S ribosome bound to antibiotic analog SLC31
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Fraser, J.S]]
-	[[Category: Pellegrino, J]]
	[[Category: Seiple, I.B]]		[[Category: Seiple, I.B]]
	[[Category: Lee, D.J]]		[[Category: Lee, D.J]]
		+	[[Category: Fraser, J.S]]
		+	[[Category: Pellegrino, J]]

OCA: Protected "8e49" [edit=sysop:move=sysop]

2022-08-25T03:54:03Z

Protected "8e49" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:54, 25 August 2022

OCA: New page: '''Unreleased structure''' The entry 8e49 is ON HOLD Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B. Description: E. coli 50S ribosome bound to antibiotic analog SLC31 [...

2022-08-25T03:54:02Z

New page: '''Unreleased structure''' The entry 8e49 is ON HOLD Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B. Description: E. coli 50S ribosome bound to antibiotic analog SLC31 [...

New page

'''Unreleased structure'''

The entry 8e49 is ON HOLD

Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.

Description: E. coli 50S ribosome bound to antibiotic analog SLC31
[[Category: Unreleased Structures]]
[[Category: Fraser, J.S]]
[[Category: Pellegrino, J]]
[[Category: Seiple, I.B]]
[[Category: Lee, D.J]]

8e49 - Revision history

OCA at 21:17, 28 June 2023

OCA at 06:34, 21 September 2022

OCA: Protected "8e49" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8e49 is ON HOLD Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B. Description: E. coli 50S ribosome bound to antibiotic analog SLC31 [...