OCA at 10:16, 24 November 2022

2022-11-24T10:16:02Z

←Older revision		Revision as of 10:16, 24 November 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8enc is ~~ON HOLD until Paper Publication~~	+	==Helical reconstruction of the human cardiac actin-tropomyosin-myosin loop 4 7G mutant complex==
-		+	<StructureSection load='8enc' size='340' side='right'caption='[[8enc]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~: ~~Doran~~, M.H., ~~Lehman~~, W., ~~Rynkiewicz~~, M.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8enc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ENC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ENC FirstGlance]. <br>
-	~~Description~~: ~~Helical reconstruction~~ of the ~~human~~ cardiac ~~actin~~-~~tropomyosin~~-~~myosin loop 4 7G mutant complex~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8enc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8enc OCA], [https://pdbe.org/8enc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8enc RCSB], [https://www.ebi.ac.uk/pdbsum/8enc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8enc ProSAT]</span></td></tr>
-	[[Category: ~~Lehman, W~~]]	+	</table>
-	[[Category: Doran~~, M.H~~]]	+	== Disease ==
-	[[Category: Rynkiewicz~~, M.J~~]]	+	[https://www.uniprot.org/uniprot/MYH7_HUMAN MYH7_HUMAN] Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1) [MIM:[https://omim.org/entry/192600 192600]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:1975517</ref> <ref>PMID:1417858</ref> <ref>PMID:1638703</ref> <ref>PMID:1552912</ref> <ref>PMID:8250038</ref> <ref>PMID:8343162</ref> <ref>PMID:8435239</ref> <ref>PMID:8268932</ref> <ref>PMID:8254035</ref> <ref>PMID:8483915</ref> <ref>PMID:7848441</ref> <ref>PMID:7874131</ref> <ref>PMID:8282798</ref> <ref>PMID:7581410</ref> <ref>PMID:7731997</ref> <ref>PMID:8655135</ref> <ref>PMID:8899546</ref> <ref>PMID:10065021</ref> <ref>PMID:9544842</ref> <ref>PMID:9829907</ref> <ref>PMID:9822100</ref> <ref>PMID:10521296</ref> <ref>PMID:10563488</ref> <ref>PMID:10329202</ref> <ref>PMID:10679957</ref> <ref>PMID:10862102</ref> <ref>PMID:11113006</ref> <ref>PMID:11214007</ref> <ref>PMID:11733062</ref> <ref>PMID:11424919</ref> <ref>PMID:11133230</ref> <ref>PMID:12081993</ref> <ref>PMID:11861413</ref> <ref>PMID:11968089</ref> <ref>PMID:12951062</ref> <ref>PMID:12566107</ref> <ref>PMID:12707239</ref> <ref>PMID:12974739</ref> <ref>PMID:12820698</ref> <ref>PMID:12975413</ref> <ref>PMID:12590187</ref> <ref>PMID:12818575</ref> <ref>PMID:15358028</ref> <ref>PMID:15563892</ref> <ref>PMID:15483641</ref> <ref>PMID:15858117</ref> <ref>PMID:16199542</ref> <ref>PMID:15856146</ref> <ref>PMID:16650083</ref> <ref>PMID:16938236</ref> <ref>PMID:17372140</ref> <ref>PMID:18403758</ref> Defects in MYH7 are the cause of myopathy myosin storage (MYOMS) [MIM:[https://omim.org/entry/608358 608358]. In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers.<ref>PMID:14520662</ref> <ref>PMID:15136674</ref> <ref>PMID:17336526</ref> Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM) [MIM:[https://omim.org/entry/181430 181430]; also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm.<ref>PMID:17336526</ref> Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S) [MIM:[https://omim.org/entry/613426 613426]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:11106718</ref> <ref>PMID:12379228</ref> <ref>PMID:15769782</ref> <ref>PMID:21846512</ref> Defects in MYH7 are the cause of myopathy distal type 1 (MPD1) [MIM:[https://omim.org/entry/160500 160500]. MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease.<ref>PMID:15322983</ref> <ref>PMID:17548557</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MYH7_HUMAN MYH7_HUMAN] Muscle contraction.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Doran MH]]
		+	[[Category: Lehman W]]
		+	[[Category: Rynkiewicz MJ]]

OCA: Protected "8enc" [edit=sysop:move=sysop]

2022-11-09T05:00:29Z

Protected "8enc" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:00, 9 November 2022

OCA: New page: '''Unreleased structure''' The entry 8enc is ON HOLD until Paper Publication Authors: Doran, M.H., Lehman, W., Rynkiewicz, M.J. Description: Helical reconstruction of the human cardiac...

2022-11-09T05:00:28Z

New page: '''Unreleased structure''' The entry 8enc is ON HOLD until Paper Publication Authors: Doran, M.H., Lehman, W., Rynkiewicz, M.J. Description: Helical reconstruction of the human cardiac...

New page

'''Unreleased structure'''

The entry 8enc is ON HOLD until Paper Publication

Authors: Doran, M.H., Lehman, W., Rynkiewicz, M.J.

Description: Helical reconstruction of the human cardiac actin-tropomyosin-myosin loop 4 7G mutant complex
[[Category: Unreleased Structures]]
[[Category: Lehman, W]]
[[Category: Doran, M.H]]
[[Category: Rynkiewicz, M.J]]

8enc - Revision history

OCA at 10:16, 24 November 2022

OCA: Protected "8enc" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8enc is ON HOLD until Paper Publication Authors: Doran, M.H., Lehman, W., Rynkiewicz, M.J. Description: Helical reconstruction of the human cardiac...